40 Results for "

CD123

" in MedChemExpress (MCE) Product Catalog:
Products (40)

40 Results for "CD123" in MCE Product Catalog:

1
1 Cited Publications
Cat. No.: HY-P99395
CAS No.: 1826831-79-1
Synonyms: JNJ 56022473; CSL 362

Target:  

Interleukin Related

Research Areas:  

Cancer

Talacotuzumab (JNJ 56022473; CSL 362) is an IgG1-type fully humanized, CD123-neutralizing monoclonal antibody containing a modified Fc structure. Talacotuzumab has KDs of 0.43 nM, 188 nM, 46 nM, 16.8 nM for CD123, CD32b/c, CD16-158F, CD16-158V, respectively. Talacotuzumab inhibits IL-3 binding to CD123, antagonizing IL-3 signaling in target cells. Talacotuzumab has mutated the Fc region to increase affinity for CD16 (FcγRIIIa), thereby enhancing antibody-dependent cell-mediated cytotoxicity (ADCC). Talacotuzumab is highly effective in vivo reducing leukemic cell growth in acute myeloid leukemia (AML) xenograft mouse models .
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Cat. No.: HY-P99234
CAS No.: 2234335-84-1

Research Areas:  

Cancer

Pivekimab is a human IgG1 monoclonal antibody that targets interleukin-3 (IL-3) and CD123. Pivekimab is used to synthesize pivekimab sunirine, a CD123-directed antibody-active molecule conjugate (ADC). Pivekimab is used in the study of blastic plasmacytoid dendritic cell neoplasm (BPDCN) .
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Cat. No.: HY-P99521
CAS No.: 2138442-13-2
Synonyms: XmAb14045

Target:  

CD3

Research Areas:  

Inflammation/Immunology Cancer

Vibecotamab (XmAb14045) is a potent bispecific antibody targeting both CD123 and CD3. Vibecotamab targets T cell-mediated killing of CD123-expressing cells, regardless of T cell antigen specificity. Vibecotamab is a full length immunoglobulin molecule. Vibecotamab can be studied in research for diseases such as Myelodysplastic syndrome and acute myeloid leukemia. Recommend Isotype Control: half-IG G1-kappa/(scFv-heavy-lambda)-h-CH2-CH3 .
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Cat. No.: HY-P99623
CAS No.: 1664355-28-5
Synonyms: MGD006; S80880

Target:  

CD3

Research Areas:  

Cancer

Flotetuzumab (MGD006; S80880) is an investigational CD123/CD3 bispecific dual-affinity retargeting antibody (DART) molecule. Flotetuzumab reactivates T cells by simultaneously binding to CD123 in target cells and CD3 in effector T cells, leading to T-cell-mediated cytotoxicity in target cells. Flotetuzumab shows inhibitory effect on a mouse model of patient-derived xenograft (PDX) in acute myeloid leukemia (AML) .
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Cat. No.: HY-P991699
CAS No.: 3035710-69-8
Synonyms: AZD9829 antibody; INT-020

Research Areas:  

Cancer

Lixarkitug (AZD9829 antibody; INT-020) is a humanized IgG1κ antibody targeting IL-3Ra/CD123. Lixarkitug can be conjugated with Samrotecan to form the intact ADC molecule lixarkitug samrotecan (AZD9829), which is used in studies of acute myeloid leukemia (AML) . The isotype control corresponding to Lixarkitug is Human IgG1 kappa, Isotype Control (HY-P99001).
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Cat. No.: HY-W001245
CAS No.: 693-95-8
4-Methylthiazole is an Apoptosis trigger. 4-Methylthiazole markedly reduces CD45 and CD123 surface markers, increases ROS levels, Caspase-3 protein levels. 4-Methylthiazole triggers Apoptosis and mitochondrial disruption. 4-Methylthiazole can be used in the research of acute promyelocytic leukemia .
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Cat. No.: HY-P990928
CAS No.: 2839556-21-5
Synonyms: APVO-436

Target:  

CD3 Interleukin Related

Research Areas:  

Inflammation/Immunology Cancer

Mipletamig (APVO-436) is a bispecific CD123 x CD3 monoclonal antibody. Mipletamig simultaneously binds to both CD3-expressing T cells and CD123-expressing cancer cells, thereby crosslinking CD123-expressing tumor cells and cytotoxic T lymphocytes (CTLs). This results in the activation and proliferation of T-cells and causes CTL-mediated cell lysis of CD123-expressing tumor cells. Mipletamig can be used for the study of acute myeloid leukemia (AML) .
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Cat. No.: HY-P990905
CAS No.: 2871775-98-1
Synonyms: SAR-443579

Target:  

Interleukin Related

Research Areas:  

Cancer

Bexatamig (SAR-443579) is a trifunctional natural killer cell engager targeting IL-3R α/CD123, NKp46/NCR1/CD335 and Fc gamma RIIIA/CD16a. Bexatamig forms a cytolytic synapse between natural killer cells and CD123-positive tumor cells. By activating natural killer cells to induce tumor cell death, Bexatamig effectively reduces the burden of CD123-positive acute myeloid leukemia (AML) blasts. Bexatamig has been granted FDA Fast Track designation, and is primarily investigated for relapsed or refractory acute myeloid leukemia, B-cell acute lymphoblastic leukemia, and high-risk myelodysplastic syndromes .
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Cat. No.: HY-P990451
Synonyms: SNG-CD123A

Target:  

Interleukin Related

Research Areas:  

Inflammation/Immunology

Anti-IL-3Ra/CD123 Antibody (SNG-CD123A) is a CHO-expressed human antibody that targets IL-3Ra/CD123. The predicted molecular weight (MW) of Anti-IL-3Ra/CD123 Antibody (SNG-CD123A) is 146.14 kDa. The isotype control for Anti-IL-3Ra/CD123 Antibody (SNG-CD123A) can refer to Human IgG1 kappa, Isotype Control (HY-P99001).
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Cat. No.: HY-P991648

Target:  

Interleukin Related

Research Areas:  

Cancer

CSL-360 is a chimeric unconjugated IgG1 monoclonal antibody targeting CD123. CSL-360 efficiently prevents the binding of IL-3 to CD123, abolishing IL-3 induced cell proliferation. CSL-360 can be used for acute myeloid leukemia (AML) research .
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Cat. No.: HY-RS06764
Research Areas:  

Others

IL3RA Human Pre-designed siRNA Set A contains three designed siRNAs for IL3RA gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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Cat. No.: HY-P991282

Target:  

Interleukin Related

Research Areas:  

Cancer

KHK2823 is a humanized monoclonal anti-human CD123/IL3RA antibody. Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001). KHK2823 can be used in research related to leukemia .
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Cat. No.: HY-P8F034A
Synonyms: CD123,CD123-FITC,6H6

Host:  

Mouse

Application:  

FC

Reactivity:  

Human

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Cat. No.: HY-P8F034C
Synonyms: CD123,CD123-PE,6H6

Host:  

Mouse

Application:  

FC

Reactivity:  

Human

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Cat. No.: HY-P8F034F
Synonyms: CD123,CD123-PerCP,6H6

Host:  

Mouse

Application:  

FC

Reactivity:  

Human

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Cat. No.: HY-P8F034I
Synonyms: CD123,CD123-APC,6H6

Host:  

Mouse

Application:  

FC

Reactivity:  

Human

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Cat. No.: HY-P8F034B
Synonyms: CD123,CD123-AF488,6H6

Host:  

Mouse

Application:  

FC

Reactivity:  

Human

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Cat. No.: HY-P8F034H
Synonyms: CD123,CD123-AF647,6H6

Host:  

Mouse

Application:  

FC

Reactivity:  

Human

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Cat. No.: HY-P8F034K
Synonyms: CD123,CD123-AF700,6H6

Host:  

Mouse

Application:  

FC

Reactivity:  

Human

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Cat. No.: HY-P8F034L
Synonyms: CD123,CD123-PC Blue,6H6

Host:  

Mouse

Application:  

FC

Reactivity:  

Human

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