Search Result
Results for "
CD25
" in MedChemExpress (MCE) Product Catalog:
| Cat. No. |
Product Name |
Target |
Research Areas |
Chemical Structure |
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- HY-P990281
-
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Interleukin Related
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Inflammation/Immunology
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Anti-Mouse CD25/IL-2Rα Antibody (PC-61.5.3) is a rat-derived IgG1 λ type antibody inhibitor, targeting to mouse CD25/IL-2Rα. Anti-Mouse CD25/IL-2Rα Antibody (PC-61.5.3) can deplete CD25+ T cells. Anti-Mouse CD25/IL-2Rα Antibody (PC-61.5.3) can be used for the researches of immunology and inflammation, such as atopic dermatitis .
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- HY-108738
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Ro 24-7375
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Interleukin Related
Apoptosis
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Inflammation/Immunology
Cancer
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Daclizumab (Ro 24-7375) is a humanized, monoclonal antibody that blocks CD25 (α-subunit of the high-affinity interleukin-2 receptor (IL-2R-HA)). Daclizumab inhibits effector T cell activation, regulatory T cell (Treg) expansion and survival, and activation-induced T-cell apoptosis. Daclizumab increases IL-2 bioavailability to bind to the intermediate-affinity IL-2R (IL-2R-IA), driving the expansion of anti-inflammatory CD56bright natural killer (NK) cells. Daclizumab can be used for multiple sclerosis and cancer research .
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- HY-155978A
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Tyrosinase
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Inflammation/Immunology
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RDN2150 (Compound 25) TFA is a ZAP-70 inhibitor (IC50: 14.6 nM). RDN2150 TFA covalently binds to the C346 residue of ZAP-70. RDN2150 TFA inhibits the expression of CD25 and CD69, and inhibits CD4 + T cell activation. RDN2150 TFA can be used for research of psoriasis .
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- HY-P99233
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HuMax-TAC
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ADC Antibody
Transmembrane Glycoprotein
Interleukin Related
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Cancer
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Camidanlumab (HuMax-TAC) is a humanized IgG1 monoclonal antibody against CD25. Camidanlumab can be used to synthesize the ADC molecule Camidanlumab tesirine (HY-141599). Camidanlumab can be used in the research of tumors such as lymphoma and leukemia. Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001) .
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- HY-P991110
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Interleukin Related
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Inflammation/Immunology
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Anti-Mouse CD25 Antibody (7D4) is a mouse IgG2 monoclonal antibody targeting CD25. Anti-Mouse CD25 Antibody (7D4) enables the isolation of naive CD4 + T cells by depleting CD25-expressing cells .
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- HY-W107024
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TGF-β Receptor
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Inflammation/Immunology
Cancer
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BMS-986260, an immuno-oncology agent, is a potent, selective, and orally active TGFβR1 inhibitor (IC50=1.6 nM). BMS-986260 displays exquisite selectivity for TGFβR1 over its isozyme TGFβR2, as well as in a panel of more than 200 kinases examined. BMS-986260 inhibits TGFβ mediated nuclear translocation of pSMAD2/3 in MINK and NHLF cells lines with an IC50 of 350 nM and 190 nM, respectively .
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- HY-P1684
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FOXP3 inhibitor P60
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NF-κB
Nuclear Factor of activated T Cells (NFAT)
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Infection
Inflammation/Immunology
Cancer
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Peptide P60 is a FOXP3 inhibitor. Peptide P60 reduces the nuclear translocation of FOXP3 and impairs FOXP3-mediated inhibition of NF-κB and NFAT activity. Peptide P60 inhibits the immunosuppressive activity of regulatory T cells and restores the proliferation and activation of effector T cells. Peptide P60 induces lymphoproliferative autoimmune syndrome in neonatal ICR mice and reduces the number of CD4 +CD25 +Foxp3 + T cells in the spleen. Peptide P60 enhances the efficacy of AH1 (HY-P4193) peptide vaccine and recombinant adenovirus-based HCV NS3 vaccine in BALB/c mice, including protective effects against CT26 tumor implantation. Peptide P60 can be used in studies related to tumor immunity, viral infection and lymphoproliferative autoimmune syndrome .
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- HY-103333
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N-Vanillylarachidonamide
|
TRP Channel
Cannabinoid Receptor
CD74
Akt
Orexin Receptor (OX Receptor)
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Neurological Disease
Inflammation/Immunology
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Arvanil (N-Vanillylarachidonamide) is a mixed agonist of CB1 and TRPV1 receptors. Arvanil downregulates CD25, HLA-DR, CD134/OX40, blocks G1/S phase transition, and induces phosphorylation of Akt. Arvanil does not induce apoptosis in cells. Arvanil inhibits lymphocyte activation and ameliorates autoimmune encephalomyelitis. Arvanil can be used in research related to Huntington's disease, vomiting, and multiple sclerosis .
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- HY-W181026
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Fluorescent Dye
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Inflammation/Immunology
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KLF10-IN-1 (#48-15) is a KLF10 inhibitor with an IC50 value of 40 μM for KLF10 reporter gene. KLF10-IN-1 can inhibit KLF10-DNA binding and transcriptional activity, block the conversion of CD4+CD25 T cells to CD4+CD25+T regulatory cells, and inhibit the expression of KLF10 target genes. KLF10-IN-1 can be used as a useful mechanistic probe to study KLF10-mediated effects and T regulatory cell biology .
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- HY-P990086
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RG-6292; RO-7296682
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Interleukin Related
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Cancer
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Vopikitug is an IgG1-kappa, anti-IL2RA (interleukin 2 receptor alpha subunit, IL-2RA, TAC, p55, CD25) homo sapiens monoclonal antibody. Vopikitug shows antineoplastic activity .
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- HY-155978
-
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Tyrosinase
|
Inflammation/Immunology
|
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RDN2150 (Compound 25) is a ZAP-70 inhibitor (IC50: 14.6 nM). RDN2150 covalently binds to the C346 residue of ZAP-70. RDN2150 inhibits the expression of CD25 and CD69, and inhibits CD4 + T cell activation. RDN2150 can be used for research of psoriasis .
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- HY-141599
-
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ADCT 301
|
Antibody-Drug Conjugates (ADCs)
Interleukin Related
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Cancer
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Camidanlumab tesirine (ADCT 301) is an ADC comprising HuMax-TAC, a human IgG1 mAb directed against human CD25, stochastically conjugated through a dipeptide cleavable linker to a pyrrolobenzodiazepine (PBD) dimer warhead. Camidanlumab tesirine has a drug–antibody ratio (DAR) of 2.3. Camidanlumab tesirine binds human CD25 with picomolar affinity. Camidanlumab tesirine has highly potent and selective cytotoxicity against a panel of CD25-expressing human lymphoma cell lines .
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- HY-P991000
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AU-007; BD-8; BDG8
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Interleukin Related
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Cardiovascular Disease
Inflammation/Immunology
Cancer
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Imneskibart (AU-007) is a human monoclonal antibody that binds to the CD25-binding epitope of interleukin-2 (IL-2), blocking the binding of IL-2 to the trimeric IL-2 receptor while retaining the ability to bind to the dimeric IL-2 receptor. Imneskibart expands effector T cell and NK cell populations, reduces regulatory T cells, increases the effector T cell/regulatory T cell ratio, and alleviates vascular leakage. Imneskibart can be used in research related to melanoma and non-small cell lung cancer. The corresponding isotype control is: Human IgG1 kappa, Isotype Control (HY-P99001) .
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- HY-P991749
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Interleukin Related
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Inflammation/Immunology
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Anti-Rat CD25 Antibody (OX-39) recognizes the 55 kDa low-affinity interleukin-2 receptor α chain (IL-2R α, CD25). Anti-Rat CD25 Antibody (OX-39) interacts with a single class of sites on the alpha chain of the rat R-IL2 with a high affinity (Kd of 0.8 nM) and competes with IL2 binding on this chain (Ki of 0.53 nM). Anti-Rat CD25 Antibody (OX-39) is a weak inhibitor in vitro on IL2-induced proliferation and in vivo on allograft rejection. Recommend Isotype Controls: Mouse IgG1 kappa, Isotype Control (HY-P99977) .
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- HY-P990866
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Interleukin Related
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Cancer
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Anti-CD25/IL-2Rα Antibody (7G7B6) is an anti-human CD25/IL-2Rα IgG2a monoclonal antibody. Anti-CD25/IL-2Rα Antibody (7G7B6) can inhibit the growth of tumors. Anti-CD25/IL-2Rα Antibody (7G7B6) can be used for research on leukemia. The recommend isotype control of Anti-CD25/IL-2Rα Antibody (7G7B6): Mouse IgG2a kappa, Isotype Control (HY-P99978) .
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- HY-159123
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MAP4K
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Cancer
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KHK-6 is an inhibitor for serine/threonine kinase hematopoietic progenitor kinase 1 (HPK 1) with an IC50 of 20 nM. KHK-6 enhances CD3/CD28-induced cytokine production, enhances CD69, CD25 and HLA-DR markers on CD4+ and CD8+ T cells, and enhances T cell-mediated killing activity of SKOV3 and A549 cells .
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- HY-P11340
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MHC
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Infection
Inflammation/Immunology
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VMAPRTLFL is a 9-mer peptide derived from the signal peptide of HLA-G and can serve as a peptide ligand for HLA-E. VMAPRTLFL plays a crucial role in regulating the functions of adaptive natural killer (NK) cells. Specifically, VMAPRTLFL enriches FcεRγ - adaptive NK cells, upregulates the expression of CD25, and enhances their proliferative activity, antibody-dependent cellular cytotoxicity (ADCC), and IFN-γ release. VMAPRTLFL can be used in research related to human cytomegalovirus (HCMV) infection, transplant rejection, and pregnancy immunity .
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- HY-P990736
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Interleukin Related
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Inflammation/Immunology
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Efercoleukin alfa is a recombinant fusion protein comprising an IL-2 fused to a human IgG1 Fc. Efercoleukin alfa binds the high-affinity IL-2 receptor alpha chain (CD25) .
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- HY-P992029
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Interleukin Related
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Inflammation/Immunology
Cancer
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RTX-003 is a monoclonal antibody targeting CD25. RTX-003 induces the death of regulatory T cells (Tregs) by targeting the IL-2 receptor α chain (CD25), and can enhance anti-tumor immune responses.
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- HY-P2520
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-
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- HY-P991270
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Interleukin Related
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Inflammation/Immunology
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MT204 is a humanized IgG1 antibody inhibitor targeting IL-2 of human and rhesus monkey origin. MT204 prevents soluble IL-2 from binding to intermediate-affinity IL-2 receptors and blocks CD25-bound IL-2 on high-affinity IL-2 receptors. MT204 has potently anti-proliferative activity with NKL cells and primary NK cells. MT204 has good tolerability and potent immunosuppressive activity in allogeneic skin graft model of rhesus monkey, promising for immunosuppressive and anti-proliferative therapy .
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- HY-161255
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NO Synthase
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Inflammation/Immunology
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3,4-DAA is an orally active Anthranilic acid derivative with potent immunosuppressive activities. 3, 4-DAA can alleviate the severity of colitis through inhibiting Th1 cells response, promoting Th2 cytokines expression and inducing CD4 +CD25 + T cells expression . 3,4-DAA suppressed expression of inducible nitric oxide synthase (iNOS) and nitric oxide (NO) release from EOC20 cells induced by IFN-γ and Lipopolysaccharide .
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- HY-RS06930
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Small Interfering RNA (siRNA)
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Others
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ISG20 Human Pre-designed siRNA Set A contains three designed siRNAs for ISG20 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
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ISG20 Human Pre-designed siRNA Set A
ISG20 Human Pre-designed siRNA Set A
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- HY-RS06748
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Small Interfering RNA (siRNA)
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Others
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IL2RA Human Pre-designed siRNA Set A contains three designed siRNAs for IL2RA gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
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IL2RA Human Pre-designed siRNA Set A
IL2RA Human Pre-designed siRNA Set A
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- HY-P11490
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MDM-2/p53
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Inflammation/Immunology
Cancer
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DPMI-ω is a dual-specificity d-peptide antagonist of oncogenic proteins MDM2 and MDMX. DPMI-ω, upon fabrication on gold nanoparticles, efficiently traverses tumor cells and kills them by reactivating the p53 signaling pathway. DPMI-ω can disrupte the p53-MDM2/MDMX complex. DPMI-ω can inhibit B16 melanoma growth and induce cells G0/G1 phase arrest. DPMI-ω can augment the efficacy of immunotherapy by expanding CD3 +/CD8 + cytotoxic T cells and suppressing CD4 +/CD25 + regulatory T cells companied with anti-PD1 antibody. DPMI-ω can be used for research of melanoma .
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- HY-RS18825
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Small Interfering RNA (siRNA)
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Others
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Il2ra Mouse Pre-designed siRNA Set A contains three designed siRNAs for Il2ra gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
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Il2ra Mouse Pre-designed siRNA Set A
Il2ra Mouse Pre-designed siRNA Set A
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- HY-D3327
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Fluorescent Dye
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Others
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PE-AF700 is a tandem fluorescent dye used for flow cytometry, consisting of the donor phycoerythrin (PE) and the acceptor Alexa Fluor 700 (AF700) (Ex/Em = 488 nm/715 nm) .
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- HY-P992109
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-
| Cat. No. |
Product Name |
Type |
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- HY-D3327
-
|
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Fluorescent Dye
|
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PE-AF700 is a tandem fluorescent dye used for flow cytometry, consisting of the donor phycoerythrin (PE) and the acceptor Alexa Fluor 700 (AF700) (Ex/Em = 488 nm/715 nm) .
|
| Cat. No. |
Product Name |
Target |
Research Area |
-
- HY-P1684
-
|
FOXP3 inhibitor P60
|
NF-κB
Nuclear Factor of activated T Cells (NFAT)
|
Infection
Inflammation/Immunology
Cancer
|
|
Peptide P60 is a FOXP3 inhibitor. Peptide P60 reduces the nuclear translocation of FOXP3 and impairs FOXP3-mediated inhibition of NF-κB and NFAT activity. Peptide P60 inhibits the immunosuppressive activity of regulatory T cells and restores the proliferation and activation of effector T cells. Peptide P60 induces lymphoproliferative autoimmune syndrome in neonatal ICR mice and reduces the number of CD4 +CD25 +Foxp3 + T cells in the spleen. Peptide P60 enhances the efficacy of AH1 (HY-P4193) peptide vaccine and recombinant adenovirus-based HCV NS3 vaccine in BALB/c mice, including protective effects against CT26 tumor implantation. Peptide P60 can be used in studies related to tumor immunity, viral infection and lymphoproliferative autoimmune syndrome .
|
-
- HY-P11340
-
|
|
MHC
|
Infection
Inflammation/Immunology
|
|
VMAPRTLFL is a 9-mer peptide derived from the signal peptide of HLA-G and can serve as a peptide ligand for HLA-E. VMAPRTLFL plays a crucial role in regulating the functions of adaptive natural killer (NK) cells. Specifically, VMAPRTLFL enriches FcεRγ - adaptive NK cells, upregulates the expression of CD25, and enhances their proliferative activity, antibody-dependent cellular cytotoxicity (ADCC), and IFN-γ release. VMAPRTLFL can be used in research related to human cytomegalovirus (HCMV) infection, transplant rejection, and pregnancy immunity .
|
-
- HY-P2520
-
-
- HY-P11490
-
|
|
MDM-2/p53
|
Inflammation/Immunology
Cancer
|
|
DPMI-ω is a dual-specificity d-peptide antagonist of oncogenic proteins MDM2 and MDMX. DPMI-ω, upon fabrication on gold nanoparticles, efficiently traverses tumor cells and kills them by reactivating the p53 signaling pathway. DPMI-ω can disrupte the p53-MDM2/MDMX complex. DPMI-ω can inhibit B16 melanoma growth and induce cells G0/G1 phase arrest. DPMI-ω can augment the efficacy of immunotherapy by expanding CD3 +/CD8 + cytotoxic T cells and suppressing CD4 +/CD25 + regulatory T cells companied with anti-PD1 antibody. DPMI-ω can be used for research of melanoma .
|
| Cat. No. |
Product Name |
Target |
Research Area |
Image |
-
- HY-P990281
-
|
|
Interleukin Related
|
Inflammation/Immunology
|
|
Anti-Mouse CD25/IL-2Rα Antibody (PC-61.5.3) is a rat-derived IgG1 λ type antibody inhibitor, targeting to mouse CD25/IL-2Rα. Anti-Mouse CD25/IL-2Rα Antibody (PC-61.5.3) can deplete CD25+ T cells. Anti-Mouse CD25/IL-2Rα Antibody (PC-61.5.3) can be used for the researches of immunology and inflammation, such as atopic dermatitis .
|
-
(5)
-
- HY-108738
-
|
Ro 24-7375
|
Interleukin Related
Apoptosis
|
Inflammation/Immunology
Cancer
|
|
Daclizumab (Ro 24-7375) is a humanized, monoclonal antibody that blocks CD25 (α-subunit of the high-affinity interleukin-2 receptor (IL-2R-HA)). Daclizumab inhibits effector T cell activation, regulatory T cell (Treg) expansion and survival, and activation-induced T-cell apoptosis. Daclizumab increases IL-2 bioavailability to bind to the intermediate-affinity IL-2R (IL-2R-IA), driving the expansion of anti-inflammatory CD56bright natural killer (NK) cells. Daclizumab can be used for multiple sclerosis and cancer research .
|
-
(5)
-
- HY-P99233
-
|
HuMax-TAC
|
ADC Antibody
Transmembrane Glycoprotein
Interleukin Related
|
Cancer
|
|
Camidanlumab (HuMax-TAC) is a humanized IgG1 monoclonal antibody against CD25. Camidanlumab can be used to synthesize the ADC molecule Camidanlumab tesirine (HY-141599). Camidanlumab can be used in the research of tumors such as lymphoma and leukemia. Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001) .
|
-
(5)
-
- HY-P991110
-
|
|
Interleukin Related
|
Inflammation/Immunology
|
|
Anti-Mouse CD25 Antibody (7D4) is a mouse IgG2 monoclonal antibody targeting CD25. Anti-Mouse CD25 Antibody (7D4) enables the isolation of naive CD4 + T cells by depleting CD25-expressing cells .
|
-
(5)
-
- HY-P990086
-
|
RG-6292; RO-7296682
|
Interleukin Related
|
Cancer
|
|
Vopikitug is an IgG1-kappa, anti-IL2RA (interleukin 2 receptor alpha subunit, IL-2RA, TAC, p55, CD25) homo sapiens monoclonal antibody. Vopikitug shows antineoplastic activity .
|
-
(5)
-
- HY-141599
-
|
ADCT 301
|
Antibody-Drug Conjugates (ADCs)
Interleukin Related
|
Cancer
|
|
Camidanlumab tesirine (ADCT 301) is an ADC comprising HuMax-TAC, a human IgG1 mAb directed against human CD25, stochastically conjugated through a dipeptide cleavable linker to a pyrrolobenzodiazepine (PBD) dimer warhead. Camidanlumab tesirine has a drug–antibody ratio (DAR) of 2.3. Camidanlumab tesirine binds human CD25 with picomolar affinity. Camidanlumab tesirine has highly potent and selective cytotoxicity against a panel of CD25-expressing human lymphoma cell lines .
|
-
(5)
-
- HY-P991000
-
|
AU-007; BD-8; BDG8
|
Interleukin Related
|
Cardiovascular Disease
Inflammation/Immunology
Cancer
|
|
Imneskibart (AU-007) is a human monoclonal antibody that binds to the CD25-binding epitope of interleukin-2 (IL-2), blocking the binding of IL-2 to the trimeric IL-2 receptor while retaining the ability to bind to the dimeric IL-2 receptor. Imneskibart expands effector T cell and NK cell populations, reduces regulatory T cells, increases the effector T cell/regulatory T cell ratio, and alleviates vascular leakage. Imneskibart can be used in research related to melanoma and non-small cell lung cancer. The corresponding isotype control is: Human IgG1 kappa, Isotype Control (HY-P99001) .
|
-
(5)
-
- HY-P991749
-
|
|
Interleukin Related
|
Inflammation/Immunology
|
|
Anti-Rat CD25 Antibody (OX-39) recognizes the 55 kDa low-affinity interleukin-2 receptor α chain (IL-2R α, CD25). Anti-Rat CD25 Antibody (OX-39) interacts with a single class of sites on the alpha chain of the rat R-IL2 with a high affinity (Kd of 0.8 nM) and competes with IL2 binding on this chain (Ki of 0.53 nM). Anti-Rat CD25 Antibody (OX-39) is a weak inhibitor in vitro on IL2-induced proliferation and in vivo on allograft rejection. Recommend Isotype Controls: Mouse IgG1 kappa, Isotype Control (HY-P99977) .
|
-
(5)
-
- HY-P990866
-
|
|
Interleukin Related
|
Cancer
|
|
Anti-CD25/IL-2Rα Antibody (7G7B6) is an anti-human CD25/IL-2Rα IgG2a monoclonal antibody. Anti-CD25/IL-2Rα Antibody (7G7B6) can inhibit the growth of tumors. Anti-CD25/IL-2Rα Antibody (7G7B6) can be used for research on leukemia. The recommend isotype control of Anti-CD25/IL-2Rα Antibody (7G7B6): Mouse IgG2a kappa, Isotype Control (HY-P99978) .
|
-
(5)
-
- HY-P990736
-
|
|
Interleukin Related
|
Inflammation/Immunology
|
|
Efercoleukin alfa is a recombinant fusion protein comprising an IL-2 fused to a human IgG1 Fc. Efercoleukin alfa binds the high-affinity IL-2 receptor alpha chain (CD25) .
|
-
(5)
-
- HY-P992029
-
|
|
Interleukin Related
|
Inflammation/Immunology
Cancer
|
|
RTX-003 is a monoclonal antibody targeting CD25. RTX-003 induces the death of regulatory T cells (Tregs) by targeting the IL-2 receptor α chain (CD25), and can enhance anti-tumor immune responses.
|
-
(5)
-
- HY-P991270
-
|
|
Interleukin Related
|
Inflammation/Immunology
|
|
MT204 is a humanized IgG1 antibody inhibitor targeting IL-2 of human and rhesus monkey origin. MT204 prevents soluble IL-2 from binding to intermediate-affinity IL-2 receptors and blocks CD25-bound IL-2 on high-affinity IL-2 receptors. MT204 has potently anti-proliferative activity with NKL cells and primary NK cells. MT204 has good tolerability and potent immunosuppressive activity in allogeneic skin graft model of rhesus monkey, promising for immunosuppressive and anti-proliferative therapy .
|
-
(5)
-
- HY-P992109
-
-
(5)
| Cat. No. |
Product Name |
|
Classification |
-
- HY-RS06930
-
|
|
|
siRNAs
Human Pre-designed siRNA Sets
|
|
ISG20 Human Pre-designed siRNA Set A contains three designed siRNAs for ISG20 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
|
-
- HY-RS06748
-
|
|
|
siRNAs
Human Pre-designed siRNA Sets
|
|
IL2RA Human Pre-designed siRNA Set A contains three designed siRNAs for IL2RA gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
|
-
- HY-RS18825
-
|
|
|
siRNAs
Mouse Pre-designed siRNA Sets
|
|
Il2ra Mouse Pre-designed siRNA Set A contains three designed siRNAs for Il2ra gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
|
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