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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
4 Results for "
CK1α degrader-1
" in MedChemExpress (MCE) Product Catalog:
Products (4)
4 Results for "CK1α degrader-1" in MCE Product Catalog:
1
1 Cited Publications
Cat. No.: HY-160532
CAS No.: 2881012-96-8
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Research Areas:
CK1α degrader-1 (Compound 82) is an orally active CK1α degrader with a DC50 of 0.105 μM. CK1α degrader-1 can be used for the research of cancer [1].
Cat. No.: HY-168654
CAS No.: 3090685-34-7
WEE1 degrader 1 (Compound 10) is a CRBN-dependent molecular glue degrader of WEE1 and casein kinase 1α (CK1α) with sub-2 nM DC50 values for both targets. WEE1 degrader 1 can be used for the research of acute lymphoblastic leukemia, acute monocytic leukemia, acute promyelocytic leukemia, colorectal adenocarcinoma, diffuse large b cell lymphoma [1].
Cat. No.: HY-175280
CAS No.: 3095033-62-5
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Lck degrader-1 is a molecular glue degrader that recruits cereblon to target LCK and CK1α. Lck degrader-1 promotes the formation of the LCK/CRBN-DDB1 ternary complex with an EC50 of 77.1 nM, and induces the degradation of LCK and CK1α. LCK degradation induced by Lck degrader-1 depends on the G415-containing helical G-loop degron, and maintains LCK-degrading activity in cells with the LCK T316I gatekeeper mutation. Lck degrader-1 can be used for research related to T-cell acute lymphoblastic leukemia (T-ALL) and LCK inhibitor resistance [1].
Cat. No.: HY-172882
CAS No.: 2983840-43-1
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IKZF2-degrader 1 is a potent and selective molecular glue degrader that selectively degrades IKZF2, with DC50 values of 0.6 nM and 2.0 nM in HEK293T cells and Jurkat cells, respectively. IKZF2-degrader 1 exerts no degrading effect on CK1α, IKZF1 and GSPT1, and shows weak activity against IKZF3. IKZF2-degrader 1 can be used in studies related to IKZF2-dependent cancers [1].
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
