2. Cell Cycle/DNA Damage Stem Cell/Wnt
  3. Casein Kinase
  4. CK1α degrader-1

CK1α degrader-1 (Compound 82) is an orally active CK1α degrader with a DC50 of 0.105 μM. CK1α degrader-1 can be used for the research of cancer.

For research use only. We do not sell to patients.

CK1α degrader-1 Chemical Structure

CK1α degrader-1 Chemical Structure

CAS No. : 2881012-96-8

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CK1α degrader-1 Related Antibodies

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Description

CK1α degrader-1 (Compound 82) is an orally active CK1α degrader with a DC50 of 0.105 μM. CK1α degrader-1 can be used for the research of cancer[1].

In Vivo


Pharmacokinetic Analysis in Model[1]

Route Dose (mg/kg) CL (mL/min/kg) C0 (ng/mL) t1/2 (hr) Vss (L/kg)
i.v. 2 10.5 6796 1.34 0.85
Route Dose (mg/kg) Cmax (ng/mL) Tmax (h) T1/2 (h) AUC(0-inf) (ng·h/mL) F (%)
p.o. 10 6080 0.67 2.03 13264 85

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

466.92

Formula

C24H23ClN4O4
CAS No.
SMILES

O=C1C2=CC=C(C(N[C@H](C3=CC=C(C=N3)Cl)C4CCC4)=O)C=C2CN1[C@@H]5C(NC(CC5)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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CK1α degrader-1 Related Classifications

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CK1α degrader-12881012-96-8Casein KinaseCK1αcancerorally activeInhibitorinhibitorinhibit

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HY-160532
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