Cat. No.: HY-160532

CK1α degrader-1

1 Cited Publications

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Based on 1 publication(s) in Google Scholar

CK1α degrader-1 (Compound 82) is an orally active CK1α degrader with a DC₅₀ of 0.105 μM. CK1α degrader-1 can be used for the research of cancer.

For research use only. We do not sell to patients.

Purity: 99.92%
CAS No.: 2881012-96-8
Formula: C₂₄H₂₃ClN₄O₄
Molecular Weight:466.92

Storage:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

CK1α degrader-1 Chemical Structure

CAS No.: 2881012-96-8

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Biological Activity
- Description
- In Vivo
Chemical Information
Publications (1)
Solvent & Solubility
- In Vitro
- In Vivo
Purity & Documentation
References
Help & FAQs
Bioz

Biological Activity

Description

CK1α degrader-1 (Compound 82) is an orally active CK1α degrader with a DC₅₀ of 0.105 μM. CK1α degrader-1 can be used for the research of cancer^[1].

All Casein Kinase Isoforms :

In Vivo

Pharmacokinetic Analysis in Model^[1]

Route	Dose (mg/kg)	CL (mL/min/kg)	C₀ (ng/mL)	t_1/2 (hr)	V_ss (L/kg)
i.v.	2	10.5	6796	1.34	0.85

Route	Dose (mg/kg)	C_max (ng/mL)	T_max (h)	T_1/2 (h)	AUC_(0-inf) (ng·h/mL)	F (%)
p.o.	10	6080	0.67	2.03	13264	85

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2881012-96-8
Appearance Solid
Molecular Weight 466.92
Formula C₂₄H₂₃ClN₄O₄
Color White to off-white
SMILES

O=C1C2=CC=C(C(N[C@H](C3=CC=C(C=N3)Cl)C4CCC4)=O)C=C2CN1[C@@H]5C(NC(CC5)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Publications (1)

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Molecules

Design and Synthesis of Novel Candidate CK1δ Proteolysis Targeting Chimeras (PROTACs). [Abstract]

2025 Nov 18;30(22):4452. PMID: 41302507

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (214.17 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.1417 mL

10.7085 mL

21.4169 mL

5 mM

0.4283 mL

2.1417 mL

4.2834 mL

10 mM

0.2142 mL

1.0708 mL

2.1417 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

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Volume _(start) Volume _(start)

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In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 5 mg/mL (10.71 mM); Clear solution

This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: ≥ 5 mg/mL (10.71 mM); Clear solution

This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 5 mg/mL (10.71 mM); Clear solution

This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (273 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Fu L, et al. Isoindolinone compounds, and uses thereof. WO2022257897A1. 2022-12-15.

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.1417 mL	10.7085 mL	21.4169 mL	53.5424 mL
	5 mM	0.4283 mL	2.1417 mL	4.2834 mL	10.7085 mL
	10 mM	0.2142 mL	1.0708 mL	2.1417 mL	5.3542 mL
	15 mM	0.1428 mL	0.7139 mL	1.4278 mL	3.5695 mL
	20 mM	0.1071 mL	0.5354 mL	1.0708 mL	2.6771 mL
	25 mM	0.0857 mL	0.4283 mL	0.8567 mL	2.1417 mL
	30 mM	0.0714 mL	0.3569 mL	0.7139 mL	1.7847 mL
	40 mM	0.0535 mL	0.2677 mL	0.5354 mL	1.3386 mL
	50 mM	0.0428 mL	0.2142 mL	0.4283 mL	1.0708 mL
	60 mM	0.0357 mL	0.1785 mL	0.3569 mL	0.8924 mL
	80 mM	0.0268 mL	0.1339 mL	0.2677 mL	0.6693 mL
	100 mM	0.0214 mL	0.1071 mL	0.2142 mL	0.5354 mL

Keywords

CK1α degrader-1

1 Cited Publications

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CK1α degrader-1

Cell Cycle/DNA Damage Compound Library

Stem Cell Signaling Compound Library

Wnt/Hedgehog/Notch Compound Library

Anti-Cancer Compound Library

Anti-Aging Compound Library

Orally Active Compound Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Bioactive Compound Library

Protein Kinase Compound Library

High-Throughput Bioactive Compound Library

Publications Citing Use of MedChemExpress (MCE) CK1α degrader-1

All Casein Kinase Isoforms

Biological Activity

Chemical Information

Publications (1)

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

CK1α degrader-1

Cell Cycle/DNA Damage Compound Library

Stem Cell Signaling Compound Library

Wnt/Hedgehog/Notch Compound Library

Anti-Cancer Compound Library

Anti-Aging Compound Library

Orally Active Compound Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Bioactive Compound Library

Protein Kinase Compound Library

High-Throughput Bioactive Compound Library

Publications Citing Use of MedChemExpress (MCE) CK1α degrader-1

All Casein Kinase Isoforms

Biological Activity

Chemical Information

Publications (1)

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

CK1α degrader-1 Related Classifications

Cat. No.: HY-160532