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CV-1

" in MedChemExpress (MCE) Product Catalog:

11

Inhibitors & Agonists

1

Biochemical Assay Reagents

1

Inhibitory Antibodies

1

Natural
Products

1

Isotope-Labeled Compounds

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-B0251
    Eplerenone
    5+ Cited Publications

    Epoxymexrenone

    		 Mineralocorticoid Receptor Endogenous Metabolite Cardiovascular Disease Cancer
    Eplerenone (Epoxymexrenone) is a selective, highly specific and orally active aldosterone blocker (SAB). Eplerenone also is a selective mineralocorticoid receptor antagonist (MRA) with IC50 value of 0.081 μM. Eplerenone can be used for the research of hypertension, atherosclerosis, chronic systolic heart failure (HF) and cardiovascular (CV) .
    Eplerenone
  • HY-23430
    TES

    		Biochemical Assay Reagents Others
    TES is an excellent hydrogen ion buffer. TES has characteristics such as an appropriate dissociation constant, a low metal-binding constant, and high water solubility. TES can be used in the research of mammalian cell culture, viruses, and so on [1] .
    TES
  • HY-112257
    S-23
    1 Publications Verification

    		 Androgen Receptor Metabolic Disease
    S-23 is an orally active selective androgen receptor modulator (SARM) with a Ki of 1.7 nM. S-23 induces androgen receptor (AR)-mediated transcriptional activation in CV-1 cells. S-23 increases prostate, seminal vesicle, and levator ani muscle weights in castrated rats [1] .
    S-23
  • HY-B1866
    Linuron
    1 Publications Verification

    		 Environmental Pollutants Androgen Receptor Herbicide Infection Metabolic Disease Cancer
    Linuron is a phenylurea herbicide widely used to control the growth of grasses and weeds in various crops and orchards. Linuron acts as a photosystem II inhibitor. It also functions as a competitive androgen receptor (AR) antagonist, with an EC50 of 200 μM and a Ki of 100 μM against rat AR, and an EC50 of 20 μM against human AR. Linuron exhibits reproductive toxicity in animals and acts as an endocrine disruptor [1] .\n
    Linuron
  • HY-125904
    4-Hydroxyretinoic acid
    1 Publications Verification

    		 RAR/RXR UGT Cytochrome P450 Apoptosis Drug Derivative Neurological Disease Inflammation/Immunology Cancer
    4-Hydroxyretinoic acid (4-HRA) is a derivative of Retinoic acid (HY-14649). 4-Hydroxyretinoic acid is formed via the catalysis of retinol by cytochrome P-450 isoenzymes. 4-Hydroxyretinoic acid also serves as a substrate for UDP-glucuronosyltransferase (s) and recombinant UGT2B7. 4-Hydroxyretinoic acid binds to the nuclear receptor RAR (Retinoic Acid Receptor), activates RAR and RXR-alpha, subsequently regulates gene expression and cell differentiation, and induces cancer cell apoptosis (Apoptosis). 4-Hydroxyretinoic acid also participates in multiple physiological processes such as immunoregulation, neuroprotection and antioxidation [1] .
    4-Hydroxyretinoic acid
  • HY-B0251R
    Eplerenone (Standard)
    Maximum Cited Publications
    8 Publications Verification

    Epoxymexrenone (Standard)

    		 Reference Standards Mineralocorticoid Receptor Endogenous Metabolite Cardiovascular Disease Cancer
    Eplerenone (Standard) is the analytical standard of Eplerenone. This product is intended for research and analytical applications. Eplerenone (Epoxymexrenone) is a selective, highly specific and orally active aldosterone blocker (SAB). Eplerenone also is a selective mineralocorticoid receptor antagonist (MRA) with IC50 value of 0.081 μM. Eplerenone can be used for the research of hypertension, atherosclerosis, chronic systolic heart failure (HF) and cardiovascular (CV) .
    Eplerenone (Standard)
  • HY-168376
    9(10)-Nitrooleate

    9(10)-Nitrated oleic acid

    		 PPAR ERK Akt NO Synthase Metabolic Disease Inflammation/Immunology
    9 (10)-Nitrooleate (9(10)-Nitrated oleic acid) is an endogenous lipid signaling mediator with vasoprotective effects. 9 (10)-Nitrooleate enhances enzymatic activity and improves nitric oxide bioavailability by inducing phosphorylation of Akt and ERK1/2, regulating the multi-site phosphorylation status of eNOS and optimizing its interaction with Hsp90. 9 (10)-Nitrooleate also activates PPARα, PPARδ and PPARγ receptors, thereby regulating adipogenesis, glucose uptake and inflammation-related gene expression, and exhibits immunosuppressive effects by inhibiting neutrophil migration and cytokine secretion. 9 (10)-Nitrooleate is widely used in studies of sepsis and related inflammatory diseases [1] .
    9(10)-Nitrooleate
  • HY-B0251S1
    Eplerenone-13C,d3

    Epoxymexrenone-13C,d3

    		 Isotope-Labeled Compounds Mineralocorticoid Receptor Endogenous Metabolite Cardiovascular Disease Cancer
    Eplerenone- 13C,d3 (Epoxymexrenone- 13C,d3) is 13C labeled Eplerenone. Eplerenone (Epoxymexrenone) is a selective, highly specific and orally active aldosterone blocker (SAB). Eplerenone also is a selective mineralocorticoid receptor antagonist (MRA) with IC50 value of 0.081 μM. Eplerenone can be used for the research of hypertension, atherosclerosis, chronic systolic heart failure (HF) and cardiovascular (CV) .
    Eplerenone-13C,d3
  • HY-145516
    Desmethyl Bosentan

    Ro 47-8634

    		 Drug Metabolite Cytochrome P450 Metabolic Disease
    Desmethyl bosentan is an active metabolite of the endothelin receptor antagonist bosentan (HY-A0013).1 Desmethyl bosentan (25 μM) activates the pregnane X receptor (PXR) in CV-1 monkey kidney cells expressing the human receptor in a reporter assay.
    Desmethyl Bosentan
  • HY-137396
    6β-Hydroxy Eplerenone

    		Endogenous Metabolite Cardiovascular Disease
    6β-Hydroxy Eplerenone is a metabolite of Eplerenone (HY-B0251). 6β-Hydroxy Eplerenone plays an important role in the research of hypertension, atherosclerosis, chronic systolic heart failure (HF) and cardiovascular (CV) .
    6β-Hydroxy Eplerenone
  • HY-P992081
    Anti-H3L Antibody (NAL_A185)

    		Orthopoxvirus Infection
    Anti-H3L Antibody (NAL_A185) is a neutralizing antibody targeting the H3L envelope protein of vaccinia virus (CV) belonging to the genus Orthopoxvirus. By binding to the H3L protein of intracellular mature virions, Anti-H3L Antibody (NAL_A185) blocks the binding of the virus to host cells, thereby neutralizing viral infectivity. Anti-H3L Antibody (NAL_A185) not only protects BALB/c mice from intranasal challenge with the lethal vaccinia virus WR strain, reducing weight loss and mortality, but also exhibits complement-dependent neutralizing activity against monkeypox virus. Among these properties, NAL_A185 is an immune target induced by the smallpox vaccine Dryvax; it elicits a robust recall antibody response and induces high-titer neutralizing antibodies in mice. Anti-H3L Antibody (NAL_A185) can be used for studies related to vaccinia virus infection, monkeypox and monkeypox disease [1] .
    Anti-H3L Antibody (NAL_A185)

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