Desmethyl Bosentan
Desmethyl bosentan is an active metabolite of the endothelin receptor antagonist bosentan (HY-A0013).1 Desmethyl bosentan (25 μM) activates the pregnane X receptor (PXR) in CV-1 monkey kidney cells expressing the human receptor in a reporter assay.
For research use only. We do not sell to patients.
- CAS No.: 253688-61-8
- Formula: C26H27N5O6S
- Molecular Weight:537.59
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Sf9 | IC50 |
26 μM
Compound: 9
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Displacement of radioligand from ETA receptor (unknown origin) expressed in fall armyworm sf9 cell membranes
Displacement of radioligand from ETA receptor (unknown origin) expressed in fall armyworm sf9 cell membranes
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[PMID: 27321813] |
Chemical Information
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CAS No. 253688-61-8
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Molecular Weight 537.59
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Formula C26H27N5O6S
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SMILES
O=S(NC1=C(OC2=C(O)C=CC=C2)C(OCCO)=NC(C3=NC=CC=N3)=N1)(C4=CC=C(C(C)(C)C)C=C4)=O
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Synonyms
Ro 47-8634
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Desmethyl Bosentan Related Classifications
HY-145516 Related Classifications
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