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Cimicifugic acid L

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (1) Calcium Channel (1) Drug Isomer (1) PARP (1)
By Research Areas:	Cancer (1) Cardiovascular Disease (1) Metabolic Disease (1)

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Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N17665

Cimicifugic acid A	Apoptosis PARP	Cancer
Cimicifugic acid A is a cytotoxic caffeic acid derivative that can be isolated from the rhizomes of Cimicifuga heracleifolia. Cimicifugic acid A shows cytotoxic activity against cancer cells, and increases expression of cleaved PARP, thereby exhibiting pro-apoptotic activity. Cimicifugic acid A can be used for colon cancer research .

HY-N17722

Cimicifugic acid L	Others	Others
Cimicifugic acid L is a Cimicifugic acid. Cimicifugic acid L can be isolated from the aerial parts of Cimicifuga simplex and Cimicifuga japonica .

HY-N15724

Cimicifugic acid E 2-E-Feruloylpiscidic acid	Others	Others
Cimicifugic acid E (2-E-Feruloylpiscidic acid) is a ferulic acid ester compound found in the rhizomes of Cimicifuga racemosa. Cimicifugic acid E is promising for research of menopausal syndrome .

HY-N8660

Cimicifugic acid B	Others	Metabolic Disease
Cimicifugic acid B is an antioxidant with an IC₅₀ of 21 µM in the DPPH assay .

HY-N12506

Cimicifugic acid F	Others	Others
Cimicifugic acid F is a hydroxycinnamic acid ester of piscidic acid isolated from the rhizomes of Cimicifuga racemosa.

HY-N15735

Cimicifugic acid D 2-Caffeoylpiscidic acid	Calcium Channel	Cardiovascular Disease
Cimicifugic acid D (2-Caffeoylpiscidic acid) is a benzyltartaric acid ester that induces vasodilation of precontracted rat aortic strips and endothelium-independent relaxation mechanism. Cimicifugic acid D inhibits extracellular Ca ²⁺ influx through receptor-operated Ca ²⁺ channels (ROC) in Norepinephrine (HY-13715)-induced contraction of rat aortic strips, without affecting voltage-dependent Ca ²⁺ channels (VDC) or K ⁺-induced contractions .

HY-N17724

Cimicifugic acid N	Drug Isomer	Others
Cimicifugic acid N is the cis-isomer of Cimicifugic acid G, can be found in the aerial parts of Cimicifuga simplex and Cimicifuga japonica .

Cimicifugic acid A	Structural Classification Actaea heracleifolia (Kom.) J. Compton Ranunculaceae Phenols Polyphenols Plants Source Classification	Apoptosis PARP
Cimicifugic acid A is a cytotoxic caffeic acid derivative that can be isolated from the rhizomes of Cimicifuga heracleifolia. Cimicifugic acid A shows cytotoxic activity against cancer cells, and increases expression of cleaved PARP, thereby exhibiting pro-apoptotic activity. Cimicifugic acid A can be used for colon cancer research .

Cimicifugic acid L	Structural Classification Monophenols Ranunculaceae Actaea japonicaThunb. Phenols Plants Source Classification	Others
Cimicifugic acid L is a Cimicifugic acid. Cimicifugic acid L can be isolated from the aerial parts of Cimicifuga simplex and Cimicifuga japonica .

Cimicifugic acid E 2-E-Feruloylpiscidic acid	Ranunculaceae Phenols Polyphenols Plants Cimicifuga racemosa (L.) Nutt. Source Classification	Others
Cimicifugic acid E (2-E-Feruloylpiscidic acid) is a ferulic acid ester compound found in the rhizomes of Cimicifuga racemosa. Cimicifugic acid E is promising for research of menopausal syndrome .

Cimicifugic acid B	Ranunculaceae Phenols Polyphenols Plants Cimicifuga racemosa (L.) Nutt. Source Classification	Others
Cimicifugic acid B is an antioxidant with an IC₅₀ of 21 µM in the DPPH assay .

Cimicifugic acid F	Ketones, Aldehydes, Acids Ranunculaceae Phenols Polyphenols Plants Cimicifuga racemosa (L.) Nutt. Source Classification	Others
Cimicifugic acid F is a hydroxycinnamic acid ester of piscidic acid isolated from the rhizomes of Cimicifuga racemosa.

Cimicifugic acid D 2-Caffeoylpiscidic acid	Ranunculaceae Phenols Polyphenols Plants Cimicifuga racemosa (L.) Nutt. Source Classification	Calcium Channel
Cimicifugic acid D (2-Caffeoylpiscidic acid) is a benzyltartaric acid ester that induces vasodilation of precontracted rat aortic strips and endothelium-independent relaxation mechanism. Cimicifugic acid D inhibits extracellular Ca ²⁺ influx through receptor-operated Ca ²⁺ channels (ROC) in Norepinephrine (HY-13715)-induced contraction of rat aortic strips, without affecting voltage-dependent Ca ²⁺ channels (VDC) or K ⁺-induced contractions .

Cimicifugic acid N	Structural Classification Ranunculaceae Actaea japonicaThunb. Phenols Polyphenols Plants Source Classification	Drug Isomer
Cimicifugic acid N is the cis-isomer of Cimicifugic acid G, can be found in the aerial parts of Cimicifuga simplex and Cimicifuga japonica .

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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Cimicifugic acid L

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