7 Results for "

Complement factor I

" in MedChemExpress (MCE) Product Catalog:
Products (7)

7 Results for "Complement factor I" in MCE Product Catalog:

Cat. No.: HY-P2969
CAS No.: 80295-66-5
Target:  

Endogenous Metabolite

Research Areas:  

Metabolic Disease

Complement factor I is a serine protease that downregulates complement activity in the fluid phase and/or on cell surfaces in conjunction with one of its cofactors, factor H (FH), complement receptor 1 (CR1/CD35), C4 binding protein (C4BP) or membrane cofactor protein (MCP/CD46) .
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Cat. No.: HY-NP004
Synonyms: CVF
Cobra Venom Factor (CVF) is a selective activator targeting complement components C3, C5, and factor B in the complement system. After binding to factor B, Cobra Venom Factor is cleaved by factor D, forming a stable C3/C5 convertase resistant to regulatory proteins H and I. This continuously hydrolyzes C3 and C5, depleting serum complement while inducing neutrophil migration, vascular leakage, and increased TNF-α levels. Cobra Venom Factor can be used to deplete complement and mimic complement activation-related pathological states, and is applied in animal models of complement-mediated diseases such as acute respiratory distress syndrome (ARDS), sepsis, and shock. Cobra Venom Factor can be isolated from the venom of cobras (e.g., Naja atra, Naja melanoleuca, Naja kaouthia, etc.) .
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Cat. No.: HY-163684
CAS No.: 2243483-63-6
Target:  

Complement System

Research Areas:  

Inflammation/Immunology

Zoracopan is a selective complement factor D (CFD) inhibitor. When administered systemically (orally or intravenously), Zoracopan accumulates and is sustained-released in ocular tissues, primarily in the choroid-retinal pigment epithelium (C-RPE) and/or iridociliary body (I-CB) .
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Cat. No.: HY-P990955
CAS No.: 2839652-75-2
Synonyms: ADX-097

Target:  

CD3 Complement System

Research Areas:  

Inflammation/Immunology

Ebribafusp alfa (ADX-097) comprising a humanized anti-C3d monoclonal antibody linked to two moieties of the first five consensus repeats of factor H (fH1-5). Ebribafusp alfa binds C3d and related fragments, catalyzes AP convertase dissociation, acts as a factor I co-factor for C3b cleavage, and delivers fH1-5 moieties to C3d-deposited tissues for local complement inhibition without systemic blockade. Ebribafusp alfa reduces glomerular C3 deposition, proteinuria, urine albumin-creatinine ratios, and urine soluble C5b-9 levels, preserves podocyte foot-process architecture, inhibits skin complement activation, and localizes to UVB-damaged primate skin. Ebribafusp alfa can be used for the research of membranous nephropathy, bullous pemphigoid, discoid lupus erythematosus, C3 glomerulopathy, IgA nephropathy, and lupus nephritis .
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Cat. No.: HY-178284
Target:  

Complement System

Research Areas:  

Inflammation/Immunology

Factor B-IN-7 (Compound (I)) is a selective Factor B inhibitor. Factor B-IN-7 inhibits Factor B-C3b interaction to suppress complement hyperactivation. Factor B-IN-7 is promising for research of paroxysmal nocturnal hemoglobinuria (PNH), C3 glomerulopathy, and age-related macular degeneration (AMD) associated with complement-mediated diseases .
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Cat. No.: HY-P703770
Purity:  ≥ 90%, as determined by reducing SDS-PAGE.;≥ 90%, as determined by HPLC.
Synonyms: CFI; C3bINA; Prev. IF; Complement factor I Heavy Chain; C3B/C4B Inactivator; Light Chain Of factor I; C3b-INA; Complement Component I; KAF; I factor (Complement); FI; CFI Protein; Konglutinogen-Activating factor; ARMD13; C3b-Inactivator; AHUS3; Complement
Species:  
Source:  
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Cat. No.: HY-P703793
Purity:  ≥ 90%, as determined by Bis-Tris PAGE.
Synonyms: CFI; C3bINA; Prev. IF; Complement factor I Heavy Chain; C3B/C4B Inactivator; Light Chain Of factor I; C3b-INA; Complement Component I; KAF; I factor (Complement); FI; CFI Protein; Konglutinogen-Activating factor; ARMD13; C3b-Inactivator; AHUS3; Complement
Species:  
Source:  
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