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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
17 Results for "
Cyclooxygenase metabolism
" in MedChemExpress (MCE) Product Catalog:
Products (17)
17 Results for "Cyclooxygenase metabolism" in MCE Product Catalog:
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3 Cited Publications
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SKF-86002 is an orally active p38 MAPK inhibitor, with anti-inflammatory, anti-arthritic and analgesic activities. SKF-86002 inhibits lipopolysaccharide (LPS)-stimulate human monocyte IL-1 and TNF-α production (IC50 = 1 μM). SKF-86002 inhibits lipoxygenase- and cyclooxygenase-mediated metabolism of arachidonic acid .
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Cat. No.: HY-W011297
CAS No.: 2566-89-4
Synonyms: Arachidonic acid methyl ester
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Methyl arachidonate is a protein kinase C activator and also an orally active substrate that undergoes esterase-mediated hydrolysis. Methyl arachidonate indirectly activates protein kinase C via eicosanoid metabolites generated through the arachidonic acid metabolic pathway, exerting effects via cyclooxygenase products at low concentrations and via lipoxygenase products at high concentrations. Methyl arachidonate can be used in studies related to lipodystrophy .
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Cat. No.: HY-114850A
CAS No.: 89847-02-9
Synonyms: Prostaglandin F2β tromethamine; PGF2β tromethamine
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(5R)-Dinoprost tromethamine (Prostaglandin F2β tromethamine) is a metabolite produced by the metabolism of arachidonic acid cyclooxygenase. (5R)-Dinoprost tromethamine induces dose-dependent release of hexosaccharide containing mucin .
Cat. No.: HY-108641
CAS No.: 116339-68-5
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SKF-86002 dihydrochloride is an orally active p38 MAPK inhibitor, with anti-inflammatory, anti-arthritic and analgesic activities. SKF-86002 dihydrochloride inhibits lipopolysaccharide (LPS)-stimulate human monocyte IL-1 and TNF-α production (IC50 = 1 μM). SKF-86002 dihydrochloride inhibits lipoxygenase- and cyclooxygenase-mediated metabolism of arachidonic acid .
Cat. No.: HY-12511R
CAS No.: 72873-74-6
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SKF-86002 (Standard) is the analytical standard of SKF-86002. This product is intended for research and analytical applications. SKF-86002 is an orally active p38 MAPK inhibitor, with anti-inflammatory, anti-arthritic and analgesic activities. SKF-86002 inhibits lipopolysaccharide (LPS)-stimulate human monocyte IL-1 and TNF-α production (IC50 = 1 μM). SKF-86002 inhibits lipoxygenase- and cyclooxygenase-mediated metabolism of arachidonic acid .
Cat. No.: HY-125396
CAS No.: 37786-07-5
Synonyms: 11-Deoxy-PGF2β
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Cat. No.: HY-113691
CAS No.: 102565-09-3
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(E)-L-652343 is a compound with potent cyclooxygenase and 5-lipoxygenase inhibitory activity. (E)-L-652343 can effectively inhibit the synthesis of products of these two pathways in vivo. (E)-L-652343 showed high sensitivity and specificity in the detection of geometric isomers in canine and human plasma. (E)-L-652343 showed selective metabolism in vivo, and the elimination rate of the E isomer was faster than that of the Z isomer .
Cat. No.: HY-19014
CAS No.: 83677-24-1
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KME-4 is an orally active dual inhibitor of 5-lipoxygenase (5-lipoxygenase) and cyclooxygenase (cyclooxygenase). KME-4 inhibits 5-lipoxygenase in the cytosol of guinea pig polymorphonuclear leukocytes (PMNL) and cyclooxygenase in rabbit platelets, with IC50 values of 0.85 μM and 0.44 μM, respectively. KME-4 can be used in studies related to arachidonic acid metabolism, inflammatory responses, and arthritis .
Cat. No.: HY-187671
CAS No.: 59756-39-7
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Enolicam sodium is a dual inhibitor of cyclooxygenase (COX) and lipoxygenase (LOX), with a COX IC50 of 1.5 μM and a 5-LOX IC50 of 3.5 μM. Enolicam sodium inhibits arachidonic acid metabolism via the COX and 5-LOX pathways. Enolicam sodium inhibits the production of reactive oxygen species (ROS), superoxide anions, hydrogen peroxide, and the release of polymorphonuclear leukocytes. Enolicam sodium is applicable to research related to acute oxidative lung injury and ocular inflammation .
Cat. No.: HY-118854
CAS No.: 36981-91-6
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Fepradinol is an orally active non-steroidal anti-inflammatory compound that alleviates inflammatory responses by stabilizing vascular walls, inhibiting increased vascular permeability, and suppressing leukocyte migration, independent of the cyclooxygenase or prostaglandin synthesis pathways. Fepradinol can be used in studies of acute inflammation, contact dermatitis, and minor sports injuries .
Cat. No.: HY-118854A
CAS No.: 1185076-47-4
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Fepradinol oxalate is an orally active non-steroidal anti-inflammatory compound that alleviates inflammatory responses by stabilizing vascular walls, inhibiting increased vascular permeability, and suppressing leukocyte migration, independent of the cyclooxygenase or prostaglandin synthesis pathways. Fepradinol oxalate can be used in studies of acute inflammation, contact dermatitis, and minor sports injuries .
Cat. No.: HY-118854B
CAS No.: 67704-50-1
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Fepradinol hydrochloride is an orally active non-steroidal anti-inflammatory compound that alleviates inflammatory responses by stabilizing vascular walls, inhibiting increased vascular permeability, and suppressing leukocyte migration, independent of the cyclooxygenase or prostaglandin synthesis pathways. Fepradinol hydrochloride can be used in studies of acute inflammation, contact dermatitis, and minor sports injuries .
Cat. No.: HY-N19724
CAS No.: 62346-20-7
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Cat. No.: HY-183483
CAS No.: 75987-18-7
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OKY-1581 is a potent, orally active and selective thromboxane A2 synthase inhibitor. OKY-1581 inhibits TXA2 synthesis and reduces the generation of its stable metabolite TXB2. OKY-1581 shifts arachidonic acid (MCE HY-109590) metabolism toward the production of prostaglandin E, prostaglandin F and 6-keto-prostaglandin F1α. OKY-1581 modulates the TXA2 / PGI2-related eicosanoid balance and inhibits arachidonic acid-induced platelet aggregation without directly inhibiting the cyclooxygenase step. At high oral doses, OKY-1581 also enhances hepatic peroxisomal β-oxidation and reduces serum triglyceride and cholesterol levels. OKY-1581 attenuates cerebral vasospasm after experimental subarachnoid hemorrhage by reducing TXA2-related vasoconstrictive signaling. OKY-1581 can be used in studies of atherosclerosis, cerebral vasospasm after subarachnoid hemorrhage and cardiovascular diseases .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
