Fepradinol oxalate
Fepradinol oxalate is an orally active non-steroidal anti-inflammatory compound that alleviates inflammatory responses by stabilizing vascular walls, inhibiting increased vascular permeability, and suppressing leukocyte migration, independent of the cyclooxygenase or prostaglandin synthesis pathways. Fepradinol oxalate can be used in studies of acute inflammation, contact dermatitis, and minor sports injuries.
For research use only. We do not sell to patients.
- CAS No.: 1185076-47-4
- Formula: C14H21NO6
- Molecular Weight:299.32
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
Description
In Vivo
Fepradinol (25 mg/kg; p.o.; single administration) oxalate inhibits dye exudation by 67.2% at 30 minutes, and inhibits dye exudation by 50% and reduces exudate volume by 27% at 3 hours in a rat zymosan-induced peritonitis model[1].
Fepradinol (25 mg/kg; oral administration; single dose) oxalate inhibits Dextran (MW 40000) (HY-112624C)-induced acute paw edema in rats for 5 hours, with the inhibitory effect reaching its peak at 30 minutes[2].
Fepradinol (25 mg/kg; p.o.; single administration) oxalate potently inhibits both the early and late phases of acute paw edema induced by Kaolin (HY-W115786) in rats, with peak inhibition achieved at 1 h[2].
Fepradinol (25 mg/kg; p.o.; single dose) oxalate inhibits both the early and late phases of Nystatin (HY-17409)-induced acute paw edema in rats, and its activity remains stable within 5 h[2].
Fepradinol (25 mg/kg; p.o.; single dose) oxalate exerts sustained inhibitory effects on PAF-induced acute paw edema in rats within 5 hours[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:Wistar (male, 5-7 weeks old, 150-200 g)[1]
-
Dosage:25 mg/kg
-
Administration:p.o.; single dose; 30 minutes before mediator challenge
-
Result:Inhibited histamine-induced vascular permeability by 81.1%.
Inhibited serotonin-induced permeability by 82.0%.
Inhibited bradykinin-induced permeability by 64.1%.
-
Animal Model:Wistar (male, 150-200 g)[1]
-
Dosage:100 mg/kg
-
Administration:p.o.; single dose; immediately after carrageenin challenge
-
Result:Reduced pleural exudate volume by 67.2%.
Inhibited leucocyte mobilization by 76.4%.
-
Animal Model:Wistar (male, 150-200 g)[1]
-
Dosage:25 mg/kg
-
Administration:p.o.; single dose; 30 minutes before zymosan challenge
-
Result:Inhibited dye extravasation by 67.2% with no effect on exudate volume at 30 minutes post-challenge.
Inhibited dye extravasation by 50% and reduced exudate volume by 27% at 3 hours post-challenge.
-
Animal Model:Wistar (male, 140-200 g)[5]
-
Dosage:25 mg/kg
-
Administration:p.o.; single dose
-
Result:Produced 56.4% inhibition of dextran-induced paw oedema at 30 minutes.
Produced 35.0% inhibition of dextran-induced paw oedema at 3 hours.
Produced 30.9% inhibition of dextran-induced paw oedema at 5 hours.\nProduced 82.8% inhibition of kaolin-induced paw oedema at 1 hour.
Produced 73.9% inhibition of kaolin-induced paw oedema at 3 hours.
Produced 43.7% inhibition of kaolin-induced paw oedema at 5 hours.\nProduced 72.6% inhibition of nystatin-induced paw oedema at 1 hour.
Produced 64.2% inhibition of nystatin-induced paw oedema at 3 hours.
Produced 63.2% inhibition of nystatin-induced paw oedema at 5 hours.\nProduced 47.0% inhibition of PAF-induced paw oedema at 30 minutes.
Produced 37.7% inhibition of PAF-induced paw oedema at 3 hours.
Produced 39.8% inhibition of PAF-induced paw oedema at 5 hours.
Chemical Information
-
CAS No. 1185076-47-4
-
Molecular Weight 299.32
-
Formula C14H21NO6
-
SMILES
O=C(C(O)=O)O.OCC(C)(C)NCC(C1=CC=CC=C1)O
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Fepradinol oxalate Related Classifications
HY-118854A Related Classifications
Powered by Bioz