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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
18 Results for "
DBA
" in MedChemExpress (MCE) Product Catalog:
Products (18)
18 Results for "DBA" in MCE Product Catalog:
9
9 Cited Publications
Research Areas:
SB-590885 is a BRAF/c-Raf kinase inhibitor that selectively targets B-Raf, and it amplifies the ERK/MAPK signaling pathway in RAS-activated cells. SB-590885 effectively inhibits the malignant proliferation, transformation and tumorigenicity of oncogenic B-Raf cells; it also induces the proliferation of erythroid progenitor cells, delays their differentiation and promotes hemoglobin synthesis, thereby improving ineffective erythropoiesis and reducing apoptosis. SB-590885 exerts a synergistic effect with TGF-β inhibitors and glucocorticoids, significantly promoting the formation of erythroid colonies in cells from patients with Diamond-Blackfan anemia (DBA). SB-590885 is mainly used in relevant studies on DBA, cisplatin-induced myelosuppression-related anemia, and pan-cancers such as melanoma and colorectal cancer .
Cat. No.: HY-W013053
CAS No.: 53-70-3
Synonyms: DBA; 1,2,5,6-Dibenzanthracene; Benzo[k]tetraphene
Research Areas:
Dibenz[a,h]anthracene (DBA) is an orally active polycyclic aromatic hydrocarbon, a by-product of incomplete combustion of organic matter, a potent carcinogen, and an agonist of AhR. Dibenz[a,h]anthracene induces dose-dependent increases in DNA adduct formation and lacZ mutation frequency. Dibenz[a,h]anthracene upregulates St3gal5. Dibenz[a,h]anthracene can be used in cancer-related research .
Cat. No.: HY-W002251
CAS No.: 5381-20-4
Cat. No.: HY-P991059
CAS No.: 2043950-09-8
Target:
Research Areas:
Cat. No.: HY-105365
CAS No.: 217170-95-1
Target:
Research Areas:
PD 175069 is a potent and selective N-type calcium channel antagonist with an IC50 of 0.32 μM. PD 175069 is efficacious in an audiogenic seizure model using DBA/2 mice. PD 175069 can be used for research on neurological conditions such as neuropathic pain and stroke .
Cat. No.: HY-NP0154
Synonyms: DBA (Rhodamine)
Cat. No.: HY-NP0176
Synonyms: DBA，Biotinylated
Cat. No.: HY-NP098
Synonyms: DBA (Fluorescein)
Cat. No.: HY-128960
CAS No.: 905449-84-5
Target:
Research Areas:
DBA-DM4 is a agent-linker conjugate composed of a potent a tubulin inhibitor DM1 and a linker SPDP to make antibody agent conjugate (ADC) .
Cat. No.: HY-W013053R
CAS No.: 53-70-3
Synonyms: DBA (Standard); 1,2,5,6-Dibenzanthracene (Standard); Benzo[k]tetraphene (Standard)
Research Areas:
Dibenz[a,h]anthracene (Standard) is the analytical standard of Dibenz[a,h]anthracene. This product is intended for research and analytical applications. Dibenz[a,h]anthracene (DBA) is a polycyclic aromatic hydrocarbon (PAH) of considerable tumorigenicity. Dibenz[a,h]anthracene results in DNA adduct formation leading to the activation of a DNA damage response. Dibenz[a,h]anthracene induces cell cycle arrest and apoptosis via both Tp53-dependent and Tp53-independent mechanisms .
Cat. No.: HY-141597
CAS No.: 250266-79-6
Target:
Research Areas:
Acid-C3-SSPy is a cleavable DBA-DM4 linker used in the synthesis of DBA-DM4 (HY-128960), a agent-linker conjugate for ADC .
Cat. No.: HY-RS12230
Target:
Research Areas:
RPS19 Human Pre-designed siRNA Set A contains three designed siRNAs for RPS19 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-100840
CAS No.: 85148-82-9
Synonyms: (S)-4-Carboxy-3-hydroxyphenylglycine
Target:
Research Areas:
(S)-4C3HPG ((S)-4-Carboxy-3-hydroxyphenylglycine) is an antagonist of metabotropic glutamate receptor 1a (mGluR 1a) and an agonist of GluR2. (S)-4C3HPG has the anticonvulsant activity and protects against audiogenic seizures in DBA/2 mice .
Cat. No.: HY-12153
CAS No.: 929562-28-7
Target:
Research Areas:
JNJ-1930942 is a selective and blood-brain barrier (BBB) penetrant α(7) nAChR positive allosteric modulator.JNJ-1930942 enhances the Choline (HY-B0282)-evoked rise in intracellular Ca 2+ levels and neurotransmission at hippocampal dentate gyrus synapses. JNJ-1930942 reverses the naturally occurring sensory gating deficit in DBA/2 mice .
Cat. No.: HY-10966R
CAS No.: 405554-55-4
Target:
Research Areas:
SB-590885 (Standard) is the analytical standard of SB-590885 (HY-10966). This product is intended for research and analytical applications. SB-590885 is a BRAF/c-Raf kinase inhibitor that selectively targets B-Raf, and it amplifies the ERK/MAPK signaling pathway in RAS-activated cells. SB-590885 effectively inhibits the malignant proliferation, transformation and tumorigenicity of oncogenic B-Raf cells; it also induces the proliferation of erythroid progenitor cells, delays their differentiation and promotes hemoglobin synthesis, thereby improving ineffective erythropoiesis and reducing apoptosis. SB-590885 exerts a synergistic effect with TGF-β inhibitors and glucocorticoids, significantly promoting the formation of erythroid colonies in cells from patients with Diamond-Blackfan anemia (DBA). SB-590885 is mainly used in relevant studies on DBA, cisplatin-induced myelosuppression-related anemia, and pan-cancers such as melanoma and colorectal cancer .
Cat. No.: HY-W013053S
CAS No.: 13250-98-1
Synonyms: DBA-d14; 1,2,5,6-Dibenzanthracene-d14; Benzo[k]tetraphene-d14
Cat. No.: HY-10966G
CAS No.: 405554-55-4
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
