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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
14 Results for "
DNA recognition
" in MedChemExpress (MCE) Product Catalog:
Products (14)
14 Results for "DNA recognition" in MCE Product Catalog:
3
3 Cited Publications
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Bractoppin is a potent and selective agent-like inhibitor of phosphopeptide recognition by the human BRCA1 tandem(t) BRCT domain (binding IC50: 74 nM). Bractoppin diminishes BRCA1 recruitment to DNA breaks, in turn suppressing damage-induced G2 arrest and assembly of the recombinase, RAD51. Bractoppin preferentially inhibits BRCA1 tBRCT-dependent steps in the DNA damage response .
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1 Cited Publications
Cat. No.: HY-N0307
CAS No.: 114902-16-8
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Cat. No.: HY-E70212
CAS No.: 91448-96-3
Synonyms: Hhal
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Hhal Methyltransferase (Hhal) is a DNA methyltransferase (recognition sequence: GCGC) .
Cat. No.: HY-129594
CAS No.: 761401-89-2
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DANP is a bulge base recognition probe that strongly and specifically binds to the single cytosine and thymine bulges. DANP could stabilize not only a single cytosine but also the thymine bulge in duplex DNA .
Cat. No.: HY-P1758
CAS No.: 153840-64-3
Synonyms: IRRP1
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Cat. No.: HY-N6181
CAS No.: 1802497-05-7
Category:
Alkaloids Human Gut Microbiota Metabolites Microorganisms Marine natural products Endogenous metabolite Disease Research Fields Marine microorganism Endocrinology
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Cat. No.: HY-N0307R
CAS No.: 114902-16-8
Cat. No.: HY-129594A
Purity: 99.29%
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DANP dihydrochloride is a bulge base recognition probe that strongly and specifically binds to the single cytosine and thymine bulges. DANP dihydrochloride could stabilize not only a single cytosine but also the thymine bulge in duplex DNA .
Cat. No.: HY-P1758A
Synonyms: IRRP1 acetate
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Cat. No.: HY-174519
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Human TLR9 mRNA encodes the human toll like receptor 9 (TLR9) protein, a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLR9 mediates cellular response to unmethylated CpG dinucleotides in bacterial DNA to mount an innate immune response.
Cat. No.: HY-179651
CAS No.: 106664-01-1
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NSD2-PWWP1-IN-6 (Compound 16) is an effective NSD2-PWWP1 inhibitor with a Kd value of 30 nM. NSD2-PWWP1-IN-6 competitively blocks the recognition of H3K36me2 and DNA by NSD2-PWWP1, thereby weakening its binding ability to nucleosomes. NSD2-PWWP1-IN-6 can be used for cancer research .
Cat. No.: HY-183631
CAS No.: 2248127-86-6
PM54 is an antitumor agent with activity across multiple cancer types. PM54 acts as a transcription and WNT/β-catenin signaling pathway inhibitor. PM54 suppresses oncogenic transcriptional programs, and key malignant pathways, while inducing DNA double-strand breaks, S-phase cell cycle arrest and apoptosis. PM54 enhances innate immune recognition, remodels the tumor microenvironment. PM54 exhibits antitumor activity as monotherapy or in combination in xenograft models. PM54 is applicable to research on various cancers and advanced solid tumors .
Cat. No.: HY-179650
CAS No.: 217798-45-3
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NSD2-PWWP1-IN-5 (Compound 13) is an effective NSD2-PWWP1 inhibitor with a Kd value of 78 nM. NSD2-PWWP1-IN-5 competitively blocks the recognition of H3K36me2 and DNA by NSD2-PWWP1, thereby weakening its binding ability to nucleosomes. NSD2-PWWP1-IN-5 inhibits the proliferation of U2OS osteosarcoma cells and induces cell cycle arrest and apoptosis. NSD2-PWWP1-IN-5 can be used for the study of osteosarcoma .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
