297 Results for "

DPPH

" in MedChemExpress (MCE) Product Catalog:
Products (297)

297 Results for "DPPH" in MCE Product Catalog:

51
DPPH
DPPH
0 Images
51 Publications Verification
Cat. No.: HY-112053
CAS No.: 1898-66-4
Purity:  98.77%
Synonyms: 2,2-Diphenyl-1-picrylhydrazyl
Target:  

Reactive Oxygen Species (ROS)

Research Areas:  

Metabolic Disease

DPPH (2,2-Diphenyl-1-picrylhydrazyl) is a stable free radical that can be used to measure the radical scavenging activity of antioxidants. The odd electron of nitrogen atom in DPPH is reduced by receiving a hydrogen atom from antioxidants to the corresponding hydrazine. DPPH method may be utilized in aqueous and nonpolar organic solvents and can be used to examine both hydrophilic and lipophilic antioxidants .
loading...
    loading...
View All Sizes
11
Pterostilbene
Pterostilbene
0 Images
11 Cited Publications
Cat. No.: HY-N0828
CAS No.: 537-42-8
Category:  

other families Monophenols Stilbenes Phenols Plants Disease Research Fields Inflammation/Immunology

Target:  

Autophagy

Pterostilbene is a stilbenoid isolated from blueberries and Pterocarpus marsupium . Shows anti-oxidant, anti-inflammatory, anti-carcinogenic, anti-diabetic and anti-obesity properties . Pterostilbene blocks ROS production , also exhibits inhibitory activity against various free radicals such as DPPH, ABTS, hydroxyl, superoxide and hydrogen peroxide .
loading...
    loading...
View All Sizes
4
10-Gingerol
10-Gingerol
0 Images
4 Cited Publications
Cat. No.: HY-N0448
CAS No.: 23513-15-7
Category:  

Zingiber officinale Roscoe Monophenols Ketones, Aldehydes, Acids Phenols Plants Disease Research Fields Inflammation/Immunology Zingiberaceae

Target:  

AMPK Reactive Oxygen Species (ROS) Akt PI3K Interleukin Related TNF Receptor Apoptosis

10-Gingerol is an AMPK agonist, which is found in the ginger oleoresin from fresh rhizome with anti-inflammatory, antioxidant and anti-proliferative activities. 10-Gingerol suppresses neointimal hyperplasia and inhibits vascular smooth muscle cell proliferation. 10-Gingerol exhibits substantial scavenging activities with an IC50 value of 10.47 μM against DPPH radical, an IC50 value of 1.68 μM against superoxide radical and an IC50 value of 1.35 μM against hydroxyl radical. 10-Gingerol inhibits the proliferation of MDA-MB-231 tumor cell line with an IC50 of 12.1 μM. 10-Gingerol suppresses the proliferation, migration, invasion, and induced apoptosis through targeting the PI3K/Akt signaling pathway in MDA-MB-231/IR cells. 10-Gingerol can be used in research on various common cancers such as ovarian cancer and colon cancer, as well as colitis and neurodegenerative diseases .
loading...
    loading...
View All Sizes
3
Oxyresveratrol
Oxyresveratrol
0 Images
3 Cited Publications
Cat. No.: HY-N1430
CAS No.: 29700-22-9
Synonyms: trans-Oxyresveratrol
Category:  

other families Stilbenes Anti-aging Other Diseases Phenols Polyphenols Plants Disease Research Fields

Target:  

Tyrosinase HSV Autophagy

Oxyresveratrol (trans-Oxyresveratrol) is a potent naturally occurring antioxidant and free radical scavenger (IC50 of 28.9 µM against DPPH free radicals). Oxyresveratrol is potent and noncompetitive tyrosinase inhibitor with an IC50 value of 1.2 µM for mushroom tyrosinase. Oxyresveratrol is effective against HSV-1, HSV-2 and varicella-zoster virus, and has neuroprotective effects .
loading...
    loading...
View All Sizes
3
Rhamnocitrin
Rhamnocitrin
0 Images
3 Cited Publications
Cat. No.: HY-N1353
CAS No.: 569-92-6
Category:  

Cardiovascular Disease Flavonols other families Flavonoids Phenols Polyphenols Plants Disease Research Fields

Target:  

p38 MAPK

Rhamnocitrin is an anti-inflammatory and antioxidant agent that targets STIM-1, NFATc3 and MAPK pathways and can scavenge DPPH (IC50=28.38 mM). Rhamnocitrin selectively inhibits oxidative stress and inflammatory responses in vascular endothelial cells and neurons. Rhamnocitrin up-regulates miR-185 to inhibit STIM-1-mediated store-operated calcium entry (SOCE), thereby blocking NFATc3 nuclear translocation and downstream inflammatory factor expression, while inducing heme oxygenase HO-1 expression and regulating the ERK/p38 MAPK pathway, inhibiting antioxidant and pro-inflammatory cytokines (such as IL-6, IL-8) and adhesion molecules (such as ICAM-1, VCAM-1). Rhamnocitrin can be used in the study of endothelial-related inflammatory diseases (such as sepsis, acute lung injury, atherosclerosis) and neuroprotection (such as oxidative damage of PC12 cells) .
loading...
    loading...
View All Sizes
2
Vanillylmandelic acid
Vanillylmandelic acid
0 Images
2 Cited Publications
Cat. No.: HY-113121
CAS No.: 55-10-7
Purity:  99.67%
Category:  

Cardiovascular Disease Microorganisms Monophenols Ketones, Aldehydes, Acids Phenols Endogenous metabolite Disease Research Fields

Target:  

Drug Metabolite Endogenous Metabolite

Vanillylmandelic acid is the endproduct of epinephrine and norepinephrine metabolism. Vanillylmandelic acid can be used as an indication of the disorder in neurotransmitter metabolism as well. Vanillylmandelic acid has antioxidant activity towards DPPH radical with an IC50 value of 33 μM .
loading...
    loading...
View All Sizes
2
Regaloside A
Regaloside A
0 Images
2 Cited Publications
Cat. No.: HY-N7931
CAS No.: 114420-66-5
Category:  

Liliaceae Monophenols Simple Phenylpropanols Phenols Phenylpropanoids Plants Lilium regale Wilson Disease Research Fields Inflammation/Immunology

Target:  

NO Synthase NF-κB

Regaloside A, a phenylpropanoid, shows significant DPPH radical scavenging activity of 58.0% at 160 ppm. Regaloside A has anti-inflammatory activity .
loading...
    loading...
View All Sizes
2
Sesamol
Sesamol
0 Images
2 Cited Publications
Cat. No.: HY-N1417
CAS No.: 533-31-3
Category:  

Monophenols Sesamum indicum Linn. Phenols Pedaliaceae Plants Disease Research Fields Cancer

Target:  

Apoptosis

Sesamol is a constituent of sesame oil. Sesamol shows a free radical scavenging activity. Sesamol shows an IC50=5.95±0.56 μg/mL in the DPPH assay. Anti-oxidant activities . Anticancer activities .
loading...
    loading...
View All Sizes
2
Tribuloside
Tribuloside
0 Images
2 Cited Publications
Cat. No.: HY-N2443
CAS No.: 22153-44-2
Category:  

Tribulus terrester Linn. Flavonols Flavonoids Zygophyllaceae Phenols Polyphenols Plants

Target:  

Phosphodiesterase (PDE) Bacterial PKA Tyrosinase TRP Channel Microphthalmia Associated Transcription Factor (MITF) Interleukin Related

Tribuloside is a flavonoid and PDE4 inhibitor (IC50: 6 μM). Tribuloside exhibits antibacterial and antioxidant activities, capable of scavenging DPPH free radicals. Tribuloside also promotes melanogenesis. Tribuloside can be used in the research of hypopigmentary diseases, sun protection, and inflammatory diseases such as acute lung injury .
loading...
    loading...
View All Sizes
2
TP-10
TP-10
0 Images
2 Cited Publications
Cat. No.: HY-14550
CAS No.: 898563-00-3
Purity:  99.88%
Target:  

Phosphodiesterase (PDE)

Research Areas:  

Cardiovascular Disease Neurological Disease

TP-10 is a selective PDE10A inhibitor with an IC50 value of 0.8 nM. TP-10 shows an antioxidant activity with IC50s of 31.72 and 16.04 μg/ml for DPPH and CUPRAC, respectively. TP-10 can be used for the research of neuropathy .
loading...
    loading...
View All Sizes
1
Procyanidol B4
Procyanidol B4
0 Images
1 Cited Publications
Cat. No.: HY-107208
CAS No.: 29106-51-2
Purity:  99.89%
Synonyms: (-)-Procyanidin B4
Category:  

other families Flavonoids Phenols Polyphenols Plants Disease Research Fields Inflammation/Immunology Biflavones

Target:  

Reactive Oxygen Species (ROS) COX Interleukin Related NO Synthase

Procyanidol B4 ((-)-Procyanidin B4) is an orally active polyphenol found in Q.gilva. Procyanidol B4 exerts antioxidant activity by scavenging DPPH (HY-112053) (IC50: 12.15 μM) and Nitro blue tetrazolium chloride (NBT) (HY-15925) (IC50: 8.67 μM). Procyanidol B4 exhibits anti-inflammatory activity by inhibiting the expression of COX-2 and IL-1β and iNOS .
loading...
    loading...
View All Sizes
1
Quercetin 3-O-(6''-O-malonyl)-β-D-glucoside
Quercetin 3-O-(6''-O-malonyl)-β-D-glucoside
0 Images
1 Cited Publications
Cat. No.: HY-N9397
CAS No.: 96862-01-0
Category:  

Apocynaceae Flavonols Flavonoids Metabolic Disease Phenols Polyphenols Plants  Apocynum venetum Linn. Disease Research Fields

Target:  

Others

Quercetin 3-O-(6''-O-malonyl)-β-D-glucoside is a flavonol glycoside. Quercetin 3-O-(6''-O-malonyl)-β-D-glucoside possesses antioxidant activity .
loading...
    loading...
View All Sizes
1
Wushanicaritin
Wushanicaritin
0 Images
1 Cited Publications
Cat. No.: HY-N4111
CAS No.: 521-45-9
Category:  

Flavonols Flavonoids Epimedium wushanense Ying Phenols Polyphenols Plants Berberidaceae Disease Research Fields Inflammation/Immunology

Target:  

Others

Wushanicaritin exhibits significant antioxidant activity (IC50=35.3 μM) in DPPH radical scavenging activity tests. Antitumor effects and anti-inflammatory property .
loading...
    loading...
View All Sizes
1
Retusin
Retusin
0 Images
1 Cited Publications
Cat. No.: HY-N6829
CAS No.: 1245-15-4
Synonyms: Quercetin-​3,​3',​4',​7-​tetramethylether
Category:  

Flavonols Flavonoids Monophenols Entada phaseoloides (L.) Merr. Labiatae Phenols Plants Disease Research Fields Inflammation/Immunology

Target:  

Tyrosinase Fungal SARS-CoV Apoptosis Reactive Oxygen Species (ROS)

Retusin (Quercetin-3,3',4',7-tetramethylether) is a tyrosinase inhibitor, with IC50 values of 50.9 μM and 51.8 μM against mushroom and intracellular tyrosinase, respectively. Retusin also acts as a free radical scavenger, melanogenesis inhibitor, anti-apoptosis agent, neuroprotective agent, antiemetic, antifungal agent, and antiviral agent. Retusin scavenges ABTS• + and DPPH• free radicals. Retusin can be used in studies related to hyperpigmentation, vomiting, Aspergillus niger infection, and COVID-19 infection .
loading...
    loading...
View All Sizes
1
Callistephin chloride
Callistephin chloride
0 Images
1 Cited Publications
Cat. No.: HY-W040045
CAS No.: 18466-51-8
Synonyms: Pelargonidin-3-O-glucoside chloride
Category:  

Anthocyans Flavonoids Other Diseases Rosaceae Phenols Polyphenols Plants Disease Research Fields Fragaria × ananassa Duch.

Target:  

Reactive Oxygen Species (ROS) COX NO Synthase p38 MAPK TNF Receptor Apoptosis

Callistephin (Pelargonidin 3-O-glucoside) chloride is an anthocyanin. Callistephin chloride regulates the expression of inflammatory (reducing iNOS/TNF-α/COX-2) and apoptosis-related proteins by inhibiting p38 phosphorylation, and enhances the protective effect of Isoflurane (HY-A0134) on microglial cell damage. Callistephin chloride significantly reduces ROS levels, eliminates DPPH free radicals, protects retinal pigment epithelial cells, and inhibits lipid peroxidation. Callistephin chloride can alleviate glutamate excitotoxicity, reduce neuronal apoptosis, and protect cerebellar granule neurons. Callistephin chloride can inhibit the proliferation and metastasis of breast cancer cells by inducing apoptosis .
loading...
    loading...
View All Sizes
1
Rhodionin
Rhodionin
0 Images
1 Cited Publications
Cat. No.: HY-N0241
CAS No.: 85571-15-9
Category:  

Flavonols Crassulaceae Metabolic Disease Plants Rhodiola crenulata (HK. f. et.Thoms) H. Ohba Flavonoids Rhodiola rosea Linn. Phenols Polyphenols Disease Research Fields

Target:  

Cholinesterase (ChE) Lipase Bacterial Cytochrome P450

Rhodionin is an orally active, multifunctional antivirulence and cytoprotective agent that targets and inhibits Lipase, sortase A (SrtA), CYP2D6 (IC50=0.761 μM), AChE (IC50=2.43-57.5 μM), and DPPH free radicals (IC50=19.49 μM). Rhodionin is isolable from the roots of Rhodiola crenulata. Rhodionin reduces postprandial serum triglyceride levels in mice by inhibiting lipase activity. Rhodionin also binds directly to SrtA to inhibit its transpeptidase activity, thereby reducing the fibrinogen adhesion and surface protein A levels of MRSA, effectively inhibiting biofilm formation and protecting against MRSA-induced cell damage. Rhodionin improves the survival rate of infected mice without affecting MRSA growth, and finds wide application in studies related to hyperlipidemia, exogenous obesity, and pneumonia induced by methicillin-resistant Staphylococcus aureus (MRSA) .
loading...
    loading...
View All Sizes
Cyclo(L-Phe-L-Pro)
Cyclo(L-Phe-L-Pro)
0 Images
Cat. No.: HY-P1934A
CAS No.: 3705-26-8
Category:  

Natural Products Microorganisms Disease Research Fields Inflammation/Immunology Cancer

Target:  

Fungal Bacterial IFNAR Reactive Oxygen Species (ROS)

Cyclo(L-Phe-L-Pro), isolated from Pseudomonas fluorescens and Pseudomonas alcaligenes cell-free culture supernatants is an antifungal cyclic dipeptide . Cyclo(L-Phe-L-Pro) inhibits IFN-β production by interfering with retinoic-acid-inducible gene-I (RIG-I) activation . Cyclo(L-Phe-L-Pro) exhibits free-radical scavenging activity with the IC50 of 24 µM in the DPPH assay .
loading...
    loading...
View All Sizes
Kaempferol-3-O-α-L-rhamnopyranosyl-(1→6)-β-D-glucopyranosyl-(1→2)-β-D-glucopyranoside
Kaempferol-3-O-α-L-rhamnopyranosyl-(1→6)-β-D-glucopyranosyl-(1→2)-β-D-glucopyranoside
0 Images
Cat. No.: HY-N8163
CAS No.: 476617-49-9
Category:  

Flavonols Flavonoids Leguminosae Sophora japonica (L.) Schott Other Diseases Phenols Polyphenols Plants Disease Research Fields

Target:  

Others

Kaempferol-3-O-α-L-rhamnopyranosyl-(1→6)-β-D-glucopyranosyl-(1→2)-β-D-glucopyranoside is an antioxidant with an IC50 of 26.6 μM (DPPH assay) .
loading...
    loading...
View All Sizes
3-(2,4-Dihydroxyphenyl)propanoic acid
3-(2,4-Dihydroxyphenyl)propanoic acid
0 Images
Cat. No.: HY-N1750
CAS No.: 5631-68-5
Category:  

Natural Products Plants Moraceae Endogenous metabolite Human Gut Microbiota Metabolites Ficus carica L. Other Diseases Phenols Polyphenols Disease Research Fields

Target:  

Tyrosinase

3-(2,4-Dihydroxyphenyl) propanoic acid (DPPacid) is a competitive Tyrosinase inhibitor. It exhibits an IC50 value of 3.02 μM against mushroom tyrosinase with L-tyrosine as the substrate, an IC50 value of 62 μM with DL-DOPA as the substrate, and a Ki value of 11.5 μM. 3-(2,4-Dihydroxyphenyl) propanoic acid shows no DPPH radical scavenging activity. It can be used in studies related to ultraviolet B (UVB)-induced hyperpigmentation .
loading...
    loading...
View All Sizes
5-Hydroxyoxindole
5-Hydroxyoxindole
0 Images
Cat. No.: HY-W001542
CAS No.: 3416-18-0
Category:  

Neurological Disease Metabolic Disease Haldina cordifolia (Roxb.) Ridsd. Plants Indole Alkaloids Alkaloids Monophenols Rubiaceae Phenols Disease Research Fields

Target:  

Reactive Oxygen Species (ROS)

5-Hydroxyoxindole is a structural analog of uric acid for its antioxidant. 5-Hydroxyoxindole has DPPH radical scavenging activities and lipid peroxidation-inhibitory activities. 5-Hydroxyoxindole is a product of partial metabolism of tryptophan involving conversion in the gut lumen of tryptophan to indole through the action of bacterial tryptophanase and tryptophan synthase. 5-Hydroxyoxindole is one of the main molecules responsible for the neurological symptoms of hepatic encephalopathy in rats. 5-Hydroxyoxindole can be used for the research of oxidative stress-mediated disorders .
loading...
    loading...
View All Sizes
Assay Types