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Results for "

Dishevelled

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (1) Na+/H+ Exchanger (NHE) (1) Wnt (6)
By Research Areas:	Cancer (3) Inflammation/Immunology (1) Metabolic Disease (2)

Inhibitors & Agonists

Peptides

Antibodies

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-117666

NSC668036 3 Publications Verification	Wnt	Inflammation/Immunology
NSC668036 is a Dishevelled (Dvl) PDZ domain inhibitor with a K_d of 237 μM. NSC668036 blocks Wnt signaling by interrupting the Frizzled-Dvl interaction .

HY-124156A

KY-02327 acetate	Wnt	Metabolic Disease
KY-02327 acetate, a metabolically stabilized KY-02061 analog, is a potent Dishevelled (Dvl)-CXXC5 interaction inhibitor. KY-02327 acetate shows an activating effect on the Wnt/β-catenin pathway, resulting in promotion of osteoblast differentiation .

HY-102067

3289-8625	Wnt	Cancer
3289-8625 is an inhibitor of the PDZ domain of *Dishevelled* (Dvl) protein (K_d=10.6 μM) and has an inhibitory effect on Wnt signaling. In addition, 3289-8625 can slow the growth of prostate cancer PC-3 cells (IC₅₀=12.5 μM). 3289-8625 can be used in the study of embryonic development and cancer .

HY-P10164

Pen-N3	Wnt	Cancer
Pen-N3 is a PDZ peptide. Pen-N3 inhibits Wnt/b-catenin signaling by recognizing dishevelled protein .

HY-124156

KY-02327	Wnt	Metabolic Disease
KY-02327, a metabolically stabilized KY-02061 analog, is a potent Dishevelled (Dvl)-CXXC5 interaction inhibitor. KY-02327 shows an activating effect on the Wnt/β-catenin pathway, resulting in promotion of osteoblast differentiation .

HY-182624

FJ9	Na+/H+ Exchanger (NHE) Wnt Apoptosis	Cancer
FJ9 is a NHERF1/PDZ inhibitor with human NHERF1 PDZ1 IC₅₀ 1540 μM, NHERF1 PDZ2 IC₅₀ 160 μM, and Frizzled-7-Dishevelled PDZ complex K_i 10 μM. FJ9 binds ligand-binding pockets of NHERF1 PDZ domains to block cognate ligand interactions, disrupts Frizzled-7-Dishevelled interactions, and down-regulates canonical Wnt signaling. FJ9 induces apoptosis in cancer cells with intact β-catenin signaling. FJ9 can be used for the research of non-small cell lung cancer, melanoma .

Cat. No.	Product Name	Target	Research Area

HY-P10164

Pen-N3	Wnt	Cancer
Pen-N3 is a PDZ peptide. Pen-N3 inhibits Wnt/b-catenin signaling by recognizing dishevelled protein .

Host:	Rabbit (3)
Reactivity:	Human (3) Rat (1) Mouse (3)
Application:	IHC-P (1) ICC/IF (1) WB (3) FC (1)
Isotype:	IgG (3)
Conjugation:	Non-conjugated (3)
Clonality:	Monoclonal (2) Recombinant (2)
Modification:	Phosphorylated (1) Unmodified (1)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P810385

	Dishevelled 2 Antibody (YA9702) Dishevelled 2 (homologous to Drosophila dsh), Dishevelled dsh homolog 2, Dishevelled segment polarity protein 2, Dishevelled-2, Dishevelled2, DSH homolog 2, DVL 2, Dvl2, DVL2_HUMAN, Segment polarity protein Dishevelled homolog DVL 2	WB, ICC/IF, IHC-P, FC	Human, Mouse, Rat
	Dishevelled 2 Antibody (YA9702) is a Rabbit-derived and non-conjugated IgG Recombinant,Monoclonal antibody, targeting to Dishevelled 2.

HY-P82943

	*Phospho-Dishevelled* 2 (Ser143) Antibody (YA2688)** DSH homolog 2	WB	Human, Mouse
	Phospho-Dishevelled 2 (Ser143) Antibody (YA2688) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-Dishevelled 2 (Ser143).

HY-P82943A

	*Phospho-Dishevelled* 2 (Ser143) Antibody (YA2688)(PBS only)** DSH homolog 2	WB	Human, Mouse
	Phospho-Dishevelled 2 (Ser143) Antibody (YA2688) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-Dishevelled 2 (Ser143).

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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