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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
12 Results for "
Exemestane
" in MedChemExpress (MCE) Product Catalog:
Products (12)
12 Results for "Exemestane" in MCE Product Catalog:
7
7 Cited Publications
Synonyms: FCE 24304; EXE
Target:
Research Areas:
Exemestane (FCE 24304) is a selective, irreversible and orally active steroidal aromatase inhibitor with IC50s of 30 nM and 40 nM for human placental and rat ovarian aromatase, respectively. Exemestane can be used for hormone-dependent breast cancer research .
Synonyms: FCE 24304(Standard); EXE (Standard)
Target:
Research Areas:
Exemestane (Standard) is the analytical standard of Exemestane. This product is intended for research and analytical applications. Exemestane (FCE 24304) is a selective, irreversible and orally active steroidal aromatase inhibitor with IC50s of 30 nM and 40 nM for human placental and rat ovarian aromatase, respectively. Exemestane can be used for hormone-dependent breast cancer research .
Cat. No.: HY-138089S
Cat. No.: HY-167845S
Cat. No.: HY-138089
CAS No.: 122370-91-6
Research Areas:
17β-Hydroxy exemestane (17-H-EXE) is the primary active metabolite of Exemestane (HY-13632). 17β-Hydroxy exemestane is an aromatase inhibitor (IC50 = 69 nM) and an androgen receptor (AR) agonist (IC50 = 39.6 nM) that is selective for AR over estrogen receptor α (ERα; IC50 = 21.2 μM). 17β-Hydroxy exemestane stimulates growth of AR- and ERα-positive MCF-7 (EC50= 2.7 μM) and T47D breast cancer cells (EC50s = 0.43 and 1500 nM for AR- and ER-mediated growth, respectively) and inhibits proliferation of testosterone-treated aromatase-overexpressing MCF-7 cells. 17β-Hydroxy exemestane inhibits increases in serum cholesterol and LDL levels and prevents decreases in bone mineral density in the lumbar vertebrae and femur, as well as femoral bending strength and compressive strength of the fifth lumbar vertebrae in ovariectomized rats .
Cat. No.: HY-13632S
Synonyms: FCE 24304-d2; EXE-d2
Cat. No.: HY-13632S2
Synonyms: FCE 24304-d3; EXE-d3
Cat. No.: HY-13632S6
Synonyms: FCE 24304-d4; EXE-d4
Cat. No.: HY-13632S1
CAS No.: 1092371-24-8
Synonyms: FCE 24304-13C3; EXE-13C3
Cat. No.: HY-13632S5
Synonyms: FCE 24304-13C,d2; EXE-13C,d2
Cat. No.: HY-W748956
Cat. No.: HY-W767663
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
