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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
18 Results for "
FBXW
" in MedChemExpress (MCE) Product Catalog:
Products (18)
18 Results for "FBXW" in MCE Product Catalog:
Cat. No.: HY-RS04818
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FBXW7 Human Pre-designed siRNA Set A contains three designed siRNAs for FBXW7 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-173082
CAS No.: 2765058-89-5
10-SLF is an FKBP12 PROTAC degrader. 10-SLF covalently interacts with the cysteine residue of FBXW7 R465C, forms a ternary complex with FKBP12, and promotes FBXW7-R465C-dependent proteasomal degradation of FKBP12. 10-SLF can be used for the research of pancreatic cancer .
Cat. No.: HY-RS04816
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FBXW11 Human Pre-designed siRNA Set A contains three designed siRNAs for FBXW11 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS04817
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FBXW5 Human Pre-designed siRNA Set A contains three designed siRNAs for FBXW5 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS04819
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FBXW8 Human Pre-designed siRNA Set A contains three designed siRNAs for FBXW8 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS16420
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FBXW2 Human Pre-designed siRNA Set A contains three designed siRNAs for FBXW2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS21128
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Fbxw11 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Fbxw11 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS21572
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Fbxw2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Fbxw2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS24007
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Fbxw7 Rat Pre-designed siRNA Set A contains three designed siRNAs for Fbxw7 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS28090
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Fbxw2 Rat Pre-designed siRNA Set A contains three designed siRNAs for Fbxw2 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS17548
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Fbxw7 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Fbxw7 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS27646
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Fbxw11 Rat Pre-designed siRNA Set A contains three designed siRNAs for Fbxw11 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-P81525A
Synonyms: FBXW7; FBW7 ; FBX30; SEL10 ; F-box/WD repeat-containing protein 7; F-box protein FBX30; SEL-10; hCdc4
Cat. No.: HY-180485
PROTAC D16-M1P2 is an orally active CRBN-mediated selective PKMYT1 PROTAC degrader, with a DC50 of 0.7 nM in CCNE1-amplified HCC1569 breast cancer cells. PROTAC D16-M1P2 induces PKMYT1 degradation via the ubiquitin-proteasome system, directly inhibits PKMYT1 kinase activity, suppresses Thr14 phosphorylation of CDK1, and depends on functional CRBN and ubiquitination-like modification processes. PROTAC D16-M1P2 can be used for the research of CCNE1-amplified breast cancer, FBXW7-mutated cholangiocarcinoma, and PPP2R1A-deficient cancers .
Cat. No.: HY-187506
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ZSL-M028 is an orally active and selective Polo-like kinase 4 (PLK4) inhibitor with an IC50 value of 1.1 nM. ZSL-M028 exhibits anti-tumor activity against TRIM37-amplified neuroblastoma, downregulates SAS6, upregulates FBXW5, induces G2-phase cell cycle arrest and apoptosis, activates the p53 signaling pathway, and inhibits tumor cell colony formation and migration. ZSL-M028 shows significant tumor growth inhibitory activity in the IMR-32 neuroblastoma xenograft model. ZSL-M028 can be used in neuroblastoma-related research .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
