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Isoforms Recommended:	FFAR1

Results for "

FFAR1

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Free Fatty Acid Receptor (11) Apoptosis (2) Enterovirus (1) GPR84 (1) Insulin Receptor (1) Isotope-Labeled Compounds (2) Reference Standards (1) Small Interfering RNA (siRNA) (3)
By Research Areas:	Inflammation/Immunology (2) Metabolic Disease (9) Neurological Disease (3)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (3)

Inhibitors & Agonists

Natural
Products

Isotope-Labeled Compounds

Oligonucleotides

Targets Recommended: Free Fatty Acid Receptor

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-W040127

Peonidin 3-O-glucoside chloride 1 Publications Verification	Insulin Receptor	Metabolic Disease
Peonidin 3-O-glucoside chloride is an agonist of the free fatty acid receptor *FFAR1* and Glucokinase. Peonidin 3-O-glucoside chloride enhances insulin secretion of pancreatic beta cells and increases glucose uptake by liver cells. Peonidin 3-O-glucoside chloride activates FFAR1, promotes the phosphorylation of related proteins in the insulin secretion pathway, and increases the expression of FFAR1. In liver cells, Peonidin 3-O-glucoside chloride activates GK and regulates proteins associated with carbohydrate metabolism. Peonidin 3-O-glucoside chloride can be used in diabetes research ^[1] .

HY-101906

DC260126 3 Publications Verification	Free Fatty Acid Receptor Apoptosis	Metabolic Disease
DC260126 is a potent antagonist of GPR40 (FFAR1). DC260126 dose-dependently inhibits GPR40-mediated Ca ²⁺ elevations stimulated by linoleic acid, oleic acid, palmitoleic acid and lauric acid (IC₅₀: 6.28, 5.96, 7.07, 4.58 μM, respectively) ^[1]. DC260126 could protect MIN6 β cells from palmitate-induced ER stress and apoptosis .

HY-W009081

Tricosanoic acid	Free Fatty Acid Receptor	Neurological Disease
Tricosanoic acid is an endogenous agonist of long-chain saturated fatty acids and free fatty acid receptor *FFAR1*, which can activate hair growth. Tricosanoic acid (C23:0) has the activity of improving cognitive function by regulating neuronal membrane fluidity, inhibiting neuroinflammatory response, participating in myelination and neuronal energy metabolism. Tricosanoic acid expression levels are low in the prefrontal cortex of Alzheimer's disease (AD) models; while better cognitive performance corresponds to higher serum concentration levels. Tricosanoic acid can be used as a biomarker for diseases related to cognitive decline ^[1].

HY-148418

TUG-499	Free Fatty Acid Receptor	Metabolic Disease
TUG-499 is a selective *free fatty acid receptor 1 (FFAR1* or GPR40) (Free Fatty Acid Receptor) agonist with a pEC₅₀** of 7.39. TUG-499 exhibits >100-fold selectivity over the related receptors FFA2, FFA3, and the nuclear receptor PPARγ and other diverse receptors, ion channels, and transporters. TUG-499 can be used for the research of type 2 diabetes ^[1]. TUG-499 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-111763

*GPR40/FFAR1* modulator 1**	Free Fatty Acid Receptor	Metabolic Disease
GPR40/FFAR1 modulator 1 is an agonist and an allosteric modulator for Gq-coupled free fatty acid receptor 1 (GPR40/FFAR1) ^[1].

HY-147351

GPR40 agonist 6	Free Fatty Acid Receptor	Metabolic Disease
GPR40 agonist 6 (Compound 7a) is a potent and selective free fatty acid receptor 1 (FFAR1 or GPR40) agonist with an EC₅₀ of 0.058 μM ^[1].

HY-148235

TP-051	Free Fatty Acid Receptor	Metabolic Disease
TP-051, a chemical probe, is a potent *FFAR1* agonist with an K_i value of 16 nM for human FFAR1. TP-051 can increase insulin secretion in rat insulinoma cells. TP-051 can be used to research type 2 diabetes ^[1].

HY-RS04874

FFAR1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
FFAR1 Human Pre-designed siRNA Set A contains three designed siRNAs for FFAR1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

FFAR1 Human Pre-designed siRNA Set A FFAR1 Human Pre-designed siRNA Set A

HY-164870

FFAR1/FFAR4 agonist-1	Free Fatty Acid Receptor	Metabolic Disease Inflammation/Immunology
FFAR1/FFAR4 agonist-1 (compound 83) is a *FFAR1/FFAR4* agonist with the EC₅₀ of 1 nM A and 4nM for *FFAR1* and *FFAR4, respectively. FFAR1/FFAR4* agonist-1 can be used for study of glycemic control ^[1].

HY-RS23415

Ffar1 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Ffar1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Ffar1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Ffar1 Rat Pre-designed siRNA Set A Ffar1 Rat Pre-designed siRNA Set A

HY-RS16972

Ffar1 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Ffar1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Ffar1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Ffar1 Mouse Pre-designed siRNA Set A Ffar1 Mouse Pre-designed siRNA Set A

HY-148247

BI-2081	Free Fatty Acid Receptor	Metabolic Disease
BI-2081, a chemical probe, is a GPR40 (FFAR1) partial agonist (EC₅₀: 4 nM). BI-2081 induces glucose depending insulin secretion and reduces the plasma glucose concentration. BI-2081 can be used in the research of metabolic diseases, in particular diabetes type 2 ^[1].

HY-101906R

DC260126 (Standard)	Reference Standards Free Fatty Acid Receptor Apoptosis	Metabolic Disease
DC260126 (Standard) is the analytical standard of DC260126 (HY-101906). This product is intended for research and analytical applications. DC260126 is a potent antagonist of GPR40 (FFAR1). DC260126 dose-dependently inhibits GPR40-mediated Ca2+ elevations stimulated by linoleic acid, oleic acid, palmitoleic acid and lauric acid (IC₅₀: 6.28, 5.96, 7.07, 4.58 μM, respectively) ^[1]. DC260126 could protect MIN6 β cells from palmitate-induced ER stress and apoptosis .

HY-178395S

Tricosanoic acid-d45	Isotope-Labeled Compounds Free Fatty Acid Receptor	Neurological Disease
Tricosanoic acid-d₄₅ is the deuterium labeled Tricosanoic acid (HY-W009081). Tricosanoic acid is an endogenous agonist of long-chain saturated fatty acids and free fatty acid receptor FFAR1, which can activate hair growth. Tricosanoic acid (C23:0) has the activity of improving cognitive function by regulating neuronal membrane fluidity, inhibiting neuroinflammatory response, participating in myelination and neuronal energy metabolism. Tricosanoic acid expression levels are low in the prefrontal cortex of Alzheimer's disease (AD) models; while better cognitive performance corresponds to higher serum concentration levels. Tricosanoic acid can be used as a biomarker for diseases related to cognitive decline ^[1].

HY-W746542

Tricosanoic acid-d3	Isotope-Labeled Compounds Free Fatty Acid Receptor	Neurological Disease
Tricosanoic acid-d₃ is the deuterium labeled Tricosanoic acid (HY-W009081). Tricosanoic acid is an endogenous agonist of long-chain saturated fatty acids and free fatty acid receptor FFAR1, which can activate hair growth. Tricosanoic acid (C23:0) has the activity of improving cognitive function by regulating neuronal membrane fluidity, inhibiting neuroinflammatory response, participating in myelination and neuronal energy metabolism. Tricosanoic acid expression levels are low in the prefrontal cortex of Alzheimer's disease (AD) models; while better cognitive performance corresponds to higher serum concentration levels. Tricosanoic acid can be used as a biomarker for diseases related to cognitive decline ^[1].

HY-182921

GPR84 antagonist 11	GPR84 Enterovirus	Inflammation/Immunology
GPR84 antagonist 11 is a highly selective GPR84 antagonist, with a human pA₂ of 8.41 and a pK_i of 8.16. GPR84 antagonist 11 competitively inhibits the binding of agonists to the orthosteric site of GPR84 and has improved druglike properties, though its metabolic stability still requires optimization. GPR84 antagonist 11 can be used in the research of autoimmune diseases and fibrotic diseases ^[1].

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-W040127

Peonidin 3-O-glucoside chloride 1 Publications Verification	Anthocyans Flavonoids Classification of Application Fields Vitis vinifera cv. Zalema Metabolic Disease Plants Vitaceae Disease Research Fields Source Classification	Insulin Receptor
Peonidin 3-O-glucoside chloride is an agonist of the free fatty acid receptor *FFAR1* and Glucokinase. Peonidin 3-O-glucoside chloride enhances insulin secretion of pancreatic beta cells and increases glucose uptake by liver cells. Peonidin 3-O-glucoside chloride activates FFAR1, promotes the phosphorylation of related proteins in the insulin secretion pathway, and increases the expression of FFAR1. In liver cells, Peonidin 3-O-glucoside chloride activates GK and regulates proteins associated with carbohydrate metabolism. Peonidin 3-O-glucoside chloride can be used in diabetes research ^[1] .

HY-W009081

Tricosanoic acid	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Free Fatty Acid Receptor
Tricosanoic acid is an endogenous agonist of long-chain saturated fatty acids and free fatty acid receptor *FFAR1*, which can activate hair growth. Tricosanoic acid (C23:0) has the activity of improving cognitive function by regulating neuronal membrane fluidity, inhibiting neuroinflammatory response, participating in myelination and neuronal energy metabolism. Tricosanoic acid expression levels are low in the prefrontal cortex of Alzheimer's disease (AD) models; while better cognitive performance corresponds to higher serum concentration levels. Tricosanoic acid can be used as a biomarker for diseases related to cognitive decline ^[1].

Cat. No.	Product Name	Chemical Structure

HY-178395S

Tricosanoic acid-d45
Tricosanoic acid-d₄₅ is the deuterium labeled Tricosanoic acid (HY-W009081). Tricosanoic acid is an endogenous agonist of long-chain saturated fatty acids and free fatty acid receptor FFAR1, which can activate hair growth. Tricosanoic acid (C23:0) has the activity of improving cognitive function by regulating neuronal membrane fluidity, inhibiting neuroinflammatory response, participating in myelination and neuronal energy metabolism. Tricosanoic acid expression levels are low in the prefrontal cortex of Alzheimer's disease (AD) models; while better cognitive performance corresponds to higher serum concentration levels. Tricosanoic acid can be used as a biomarker for diseases related to cognitive decline ^[1].

Tricosanoic acid-d45

Tricosanoic acid-d₄₅ is the deuterium labeled Tricosanoic acid (HY-W009081). Tricosanoic acid is an endogenous agonist of long-chain saturated fatty acids and free fatty acid receptor FFAR1, which can activate hair growth. Tricosanoic acid (C23:0) has the activity of improving cognitive function by regulating neuronal membrane fluidity, inhibiting neuroinflammatory response, participating in myelination and neuronal energy metabolism. Tricosanoic acid expression levels are low in the prefrontal cortex of Alzheimer's disease (AD) models; while better cognitive performance corresponds to higher serum concentration levels. Tricosanoic acid can be used as a biomarker for diseases related to cognitive decline ^[1].

HY-W746542

Tricosanoic acid-d3
Tricosanoic acid-d₃ is the deuterium labeled Tricosanoic acid (HY-W009081). Tricosanoic acid is an endogenous agonist of long-chain saturated fatty acids and free fatty acid receptor FFAR1, which can activate hair growth. Tricosanoic acid (C23:0) has the activity of improving cognitive function by regulating neuronal membrane fluidity, inhibiting neuroinflammatory response, participating in myelination and neuronal energy metabolism. Tricosanoic acid expression levels are low in the prefrontal cortex of Alzheimer's disease (AD) models; while better cognitive performance corresponds to higher serum concentration levels. Tricosanoic acid can be used as a biomarker for diseases related to cognitive decline ^[1].

Tricosanoic acid-d3

Tricosanoic acid-d₃ is the deuterium labeled Tricosanoic acid (HY-W009081). Tricosanoic acid is an endogenous agonist of long-chain saturated fatty acids and free fatty acid receptor FFAR1, which can activate hair growth. Tricosanoic acid (C23:0) has the activity of improving cognitive function by regulating neuronal membrane fluidity, inhibiting neuroinflammatory response, participating in myelination and neuronal energy metabolism. Tricosanoic acid expression levels are low in the prefrontal cortex of Alzheimer's disease (AD) models; while better cognitive performance corresponds to higher serum concentration levels. Tricosanoic acid can be used as a biomarker for diseases related to cognitive decline ^[1].

FFAR1 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
FFAR1 Human Pre-designed siRNA Set A contains three designed siRNAs for FFAR1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

Ffar1 Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Ffar1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Ffar1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Ffar1 Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Ffar1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Ffar1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

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