1 Result for "

GEO

" in MedChemExpress (MCE) Product Catalog:
Products (1)

1 Results for "GEO" in MCE Product Catalog:

3
3 Cited Publications
Cat. No.: HY-10251
CAS No.: 714971-09-2
Synonyms: AC480
Target:  

EGFR

Research Areas:  

Cancer

BMS-599626 (AC480) is a selective and orally bioavailable HER1 and HER2 inhibitor, with IC50s of 20 and 30 nM, respectively. BMS-599626 displays ~8-fold less potent to HER4 (IC50=190 nM), >100-fold to VEGFR2, c-Kit, Lck, MEK. BMS-599626 inhibits tumor cell proliferation, and has potential to increase tumor response to radiotherapy .
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