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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
14 Results for "
GPR52
" in MedChemExpress (MCE) Product Catalog:
Products (14)
14 Results for "GPR52" in MCE Product Catalog:
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TP-024 (FTBMT), a chemical probe, is a selective GPR52 agonist with an EC50 of 75 nM . TP-024 has antipsychotic and procognitive properties .
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1 Cited Publications
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PW0787 is a potent, selective, orally active, and brain-penetrant GPR52 agonist (EC50=135 nM). PW0787 suppresses psychostimulant behavior .
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GPR52 antagonist-1 (Compound 43) is a GPR52 antagonist with an IC50 of 0.63 μM. GPR52 antagonist-1 reduces mHTT (mutant huntingtin protein) levels by targeting GPR52 and promotes survival of mouse primary striatal neurons .
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GPR52 agonist-1 is a potent, orally active and blood-brain barrier (BBB) penetrant GPR52 agonist with an pEC50 value of 7.53. GPR52 agonist-1 affects cAMP accumulation through direct interaction with GPR52. GPR52 agonist-1 can significantly suppress Methamphetamine-induced hyperactivity in mice. Antipsychotic activity .
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NXE0041178 is an orally active and BBB-penetrant full GPR52 agonist, with a pEC50 of 7.5 for human GPR52 and an EC50 of 27.5 nM (pEC50 = 7.55) for rat GPR52. NXE0041178 shows no significant inhibition on hERG, hNaV1.5 and cytochrome P450 isoforms. NXE0041178 can reduce d-amphetamine-induced hyperactivity in rats. NXE0041178 can be used for research of Neurological disease .
Cat. No.: HY-176900
CAS No.: 1313195-88-8
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GPR52 agonist-4 (Compound 65) is a highly selective G-protein-coupled receptor GPR52 modulator. GPR52 agonist-4 is promising for research of neuropsychiatric diseases .
Cat. No.: HY-163671
CAS No.: 2767348-36-5
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PW0729 is a selective GPR52 agonist. PW0729 activates G protein/cAMP signaling pathway, with bias toward this pathway over β-arrestin recruitment, and induces GPR52 desensitization. PW0729 can be used for the research of neuropsychiatric and neurological diseases .
Cat. No.: HY-RS05718
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GPR52 Human Pre-designed siRNA Set A contains three designed siRNAs for GPR52 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS05719
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Gpr52 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Gpr52 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS05720
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Gpr52 Rat Pre-designed siRNA Set A contains three designed siRNAs for Gpr52 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-184192
CAS No.: 3066783-67-0
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R-185 is an orally active and brain-penetrant GPR52 agonist. R-185 activates GPR52 to increase intracellular cAMP levels. R-185 can be used for the research of schizophrenia .
Cat. No.: HY-183945
CAS No.: 1313195-84-4
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WO-459 is a potent Gpr52 agonist. WO-459 induces dose-dependent elevation of intracellular cAMP in cells expressing Gpr52. WO-459 can be used for the research of Huntington’s disease and psychotic disorders .
Cat. No.: HY-P703263
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: G-protein coupled receptor 52; GPR52; Homo sapiens; Human; G-protein coupled receptor; Receptor; Transducer
Cat. No.: HY-101787R
CAS No.: 1358575-02-6
Synonyms: FTBMT (Standard)
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TP-024 (Standard) (FTBMT (Standard)) is the analytical standard of TP-024 (HY-101787). This product is intended for research and analytical applications. TP-024 (FTBMT), a chemical probe, is a selective GPR52 agonist with an EC50 of 75 nM . TP-024 has antipsychotic and procognitive properties .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
