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Glucose 6-phosphate isomerase

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Glucose-6-Phosphate Isomerase (GPI) (3) Akt (1) Apoptosis (1) Biochemical Assay Reagents (1) Casein Kinase (1) Endogenous Metabolite (11) Flavivirus (1) Hexokinase (2) Isotope-Labeled Compounds (1) mTOR (4) PI3K (1) Reference Standards (1) Virus Protease (1)
By Research Areas:	Cancer (4) Cardiovascular Disease (2) Infection (1) Metabolic Disease (10) Neurological Disease (1)

Inhibitors & Agonists

Biochemical Assay Reagents

Natural
Products

Isotope-Labeled Compounds

Antibodies

Targets Recommended: Glucose-6-Phosphate Isomerase (GPI) GLUT Phosphomannose Isomerase (PMI) SGLT PIN1

Art. -Nr.	Produktname	Target	Forschungsgebiete	Chemical Structure

HY-W011184

6-Phosphogluconic acid trisodium	Endogenous Metabolite	Metabolic Disease
6-Phosphogluconic acid trisodium is a potent and competitive *phosphoglucose isomerase* (PGI) inhibitor with K_i*s of 48 μM for glucose* 6-phosphate and 42 μM for fructose 6-phosphate. 6-Phosphogluconic acid trisodium is an endogenous metabolite .

HY-112537

D-Glucose 6-phosphate 4 Publications Verification	Endogenous Metabolite mTOR	Cardiovascular Disease Metabolic Disease
D-Glucose 6-phosphate is a key central node metabolite in glucose metabolism. It serves as the initiating metabolite for glycolysis and the pentose phosphate pathway, as well as a substrate for glycogen synthesis. D-Glucose 6-phosphate acts as a metabolic stress signal, which activates the mTOR pathway to promote protein synthesis, especially when phosphoglucose isomerase (PGI) is inhibited, thereby participating in cardiac remodeling processes. D-Glucose 6-phosphate can be used in research related to non-insulin-dependent diabetes mellitus and heart failure .

HY-113514

6-Phosphogluconic acid	Endogenous Metabolite	Metabolic Disease
6-Phosphogluconic acid is a potent and competitive *phosphoglucose isomerase* (PGI) inhibitor with K_i*s of 48 μM for glucose* 6-phosphate and 42 μM for fructose 6-phosphate. 6-Phosphogluconic acid is an endogenous metabolite .

HY-139409A

2-Deoxy-D-glucose 6-phosphate disodium 2 Publications Verification	Hexokinase Glucose-6-Phosphate Isomerase (GPI)	Cancer
2-Deoxy-D-glucose 6-phosphate disodium is an ATP-competitive, 2-deoxy-D-glucose non-competitive Hexokinase inhibitor, with a K_i value of 1.45 mM against bovine heart hexokinase. 2-Deoxy-D-glucose 6-phosphate disodium exerts ATP-competitive and 2-deoxy-D-glucose non-competitive inhibitory effects on bovine heart hexokinase. 2-DG inhibits glycolysis via the production and intracellular accumulation of 2-Deoxy-D-glucose 6-phosphate disodium, thereby inhibiting the functions of hexokinase and **Glucose-6-phosphate isomerase*, and inducing cell death. 2-Deoxy-D-glucose* 6-phosphate disodium can be used in cancer-related research .

HY-N6841

Rhodiolin 1 Publications Verification	Glucose-6-Phosphate Isomerase (GPI) Casein Kinase Virus Protease Flavivirus PI3K Akt mTOR Apoptosis	Infection Cancer
Rhodiolin, a flavonoid, is an orally active glucose 6-phosphate isomerase (GPI) inhibitor. Rhodiolin inhibits papillary thyroid cancer (PTC) by targeting glycolysis enzyme glucose 6-phosphate isomerase GPI and suppressing PI3K/AKT/mTOR phosphorylation and induce apoptosis. Rhodiolin as a NS2B-NS3 protease inhibitor can disrupt dengue viral replication. Rhodiolin is also a potential candidate for developing anticancer strategies inhibiting CK1ε kinase. Rhodiolin can be used for the study of anti-tumor and anti-viral .

HY-P2918

Phosphoglucose Isomerase, Rabbit muscle GPI; PhosphoGlucose isomerase	Endogenous Metabolite	Metabolic Disease Cancer
Phosphoglucose Isomerase, Rabbit muscle (GPI), i.e., phosphoglucose isomerase/phosphoglucoisomerase (PGI) or phosphohexose isomerase (PHI), is often used in biochemical studies. Glucose 6-phosphate isomeras is a highly conserved glycolytic and dimeric enzyme. Glucose 6-phosphate isomeras catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate .

HY-112537S2

D-Glucose 6-phosphate-13C	Isotope-Labeled Compounds Endogenous Metabolite mTOR	Others
D-Glucose 6-phosphate- ¹³C is ¹³C labeled D-Glucose 6-phosphate (HY-112537). D-Glucose 6-phosphate is a key central node metabolite in glucose metabolism. It serves as the initiating metabolite for glycolysis and the pentose phosphate pathway, as well as a substrate for glycogen synthesis. D-Glucose 6-phosphate acts as a metabolic stress signal, which activates the mTOR pathway to promote protein synthesis, especially when phosphoglucose isomerase (PGI) is inhibited, thereby participating in cardiac remodeling processes. D-Glucose 6-phosphate can be used in research related to non-insulin-dependent diabetes mellitus and heart failure.

HY-167805

D-Glucose 6-phosphate potassium	Biochemical Assay Reagents
D-Glucose 6-phosphate potassium is a biologically active compound that has the activity of being a substrate for glucose-6-phosphate isomerase. D-Glucose 6-phosphate potassium can participate in the sugar metabolism process and promote the production and utilization of energy in cells.

HY-W011184R

6-Phosphogluconic acid trisodium (Standard)	Reference Standards Endogenous Metabolite	Metabolic Disease
6-Phosphogluconic acid trisodium (Standard) is the analytical standard of 6-Phosphogluconic acid trisodium (HY-W011184). This product is intended for research and analytical applications. 6-Phosphogluconic acid trisodium is a potent and competitive *phosphoglucose isomerase* (PGI) inhibitor with K_i*s of 48 μM for glucose* 6-phosphate and 42 μM for fructose 6-phosphate. 6-Phosphogluconic acid trisodium is an endogenous metabolite.

HY-139409

2-Deoxy-D-glucose 6-phosphate	Hexokinase Glucose-6-Phosphate Isomerase (GPI)	Cancer
2-Deoxy-D-glucose 6-phosphate disodium is an ATP-competitive and 2-deoxy-D-glucose non-competitive Hexokinase inhibitor, with a K_i value of 1.45 mM against bovine heart hexokinase. 2-Deoxy-D-glucose 6-phosphate disodium exerts ATP-competitive and 2-deoxy-D-glucose non-competitive inhibitory effects on bovine heart hexokinase. 2-DG inhibits glycolysis via the generation and intracellular accumulation of 2-Deoxy-D-glucose 6-phosphate disodium, thereby inhibiting the functions of hexokinase and **Glucose-6-phosphate isomerase*, and inducing cell death. 2-Deoxy-D-glucose* 6-phosphate disodium can be used in cancer-related research .

HY-112537A

D-Glucose 6-phosphate dipotassium	Endogenous Metabolite mTOR	Cardiovascular Disease Metabolic Disease
D-Glucose 6-phosphate dipotassium is a key central node metabolite in glucose metabolism. It serves as the initiating metabolite for glycolysis and the pentose phosphate pathway, as well as a substrate for glycogen synthesis. D-Glucose 6-phosphate dipotassium acts as a metabolic stress signal, which activates the mTOR pathway to promote protein synthesis, especially when phosphoglucose isomerase (PGI) is inhibited, thereby participating in cardiac remodeling processes. D-Glucose 6-phosphate dipotassium can be used in research related to non-insulin-dependent diabetes mellitus and heart failure .

HY-W725496

D-Fructose 6-phosphate dipotassium	Endogenous Metabolite	Neurological Disease Metabolic Disease
D-Fructose 6-phosphate dipotassium is an endogenous metabolite in saliva that affects cell growth and autophagy; it can be hydrolyzed by Fructose-1,6-bisphosphatase (FBPase). D-Fructose 6-phosphate dipotassium can be converted into D-glucose 6-phosphate (HY-112537) by the action of phosphoglucose isomerase. D-Fructose 6-phosphate dipotassium is a sugar intermediate in the glycolysis pathway and the pentose phosphate pathway. D-Fructose 6-phosphate dipotassium can be used to study Lewy body dementia .

HY-P2918D

Phosphoglucose isomerase, E.coli	Endogenous Metabolite	Metabolic Disease
Phosphoglucose isomerase, E.coli (EC 5.3.1.9) is an enzyme crucial for the interconversion of D-glucose 6-phosphate and D-fructose 6-phosphate. Phosphoglucose isomerase is responsible for the second step of glycolysis and is involved in glucogenesis.

HY-P2918E

Phosphoglucose isomerase, Bacillus subtilis	Endogenous Metabolite	Metabolic Disease
Phosphoglucose isomerase, Bacillus subtilis (EC 5.3.1.9) is an enzyme crucial for the interconversion of D-glucose 6-phosphate and D-fructose 6-phosphate. Phosphoglucose isomerase is responsible for the second step of glycolysis and is involved in glucogenesis.

HY-P2918C

Phosphoglucose isomerase, Saccharomyces cerevisiae	Endogenous Metabolite	Metabolic Disease
Phosphoglucose isomerase, Saccharomyces cerevisiae (EC 5.3.1.9) is an enzyme crucial for the interconversion of D-glucose 6-phosphate and D-fructose 6-phosphate. Phosphoglucose isomerase is responsible for the second step of glycolysis and is involved in glucogenesis.

Art. -Nr.	Produktname	Type

HY-167805

D-Glucose 6-phosphate potassium	Biochemical Assay Reagents
D-Glucose 6-phosphate potassium is a biologically active compound that has the activity of being a substrate for glucose-6-phosphate isomerase. D-Glucose 6-phosphate potassium can participate in the sugar metabolism process and promote the production and utilization of energy in cells.

HY-112537A

D-Glucose 6-phosphate dipotassium	Biochemical Assay Reagents
D-Glucose 6-phosphate dipotassium is a key central node metabolite in glucose metabolism. It serves as the initiating metabolite for glycolysis and the pentose phosphate pathway, as well as a substrate for glycogen synthesis. D-Glucose 6-phosphate dipotassium acts as a metabolic stress signal, which activates the mTOR pathway to promote protein synthesis, especially when phosphoglucose isomerase (PGI) is inhibited, thereby participating in cardiac remodeling processes. D-Glucose 6-phosphate dipotassium can be used in research related to non-insulin-dependent diabetes mellitus and heart failure .

D-Glucose 6-phosphate dipotassium

Biochemical Assay Reagents

D-Glucose 6-phosphate dipotassium is a key central node metabolite in glucose metabolism. It serves as the initiating metabolite for glycolysis and the pentose phosphate pathway, as well as a substrate for glycogen synthesis. D-Glucose 6-phosphate dipotassium acts as a metabolic stress signal, which activates the mTOR pathway to promote protein synthesis, especially when phosphoglucose isomerase (PGI) is inhibited, thereby participating in cardiac remodeling processes. D-Glucose 6-phosphate dipotassium can be used in research related to non-insulin-dependent diabetes mellitus and heart failure .

HY-W725496

D-Fructose 6-phosphate dipotassium	Biochemical Assay Reagents
D-Fructose 6-phosphate dipotassium is an endogenous metabolite in saliva that affects cell growth and autophagy; it can be hydrolyzed by Fructose-1,6-bisphosphatase (FBPase). D-Fructose 6-phosphate dipotassium can be converted into D-glucose 6-phosphate (HY-112537) by the action of phosphoglucose isomerase. D-Fructose 6-phosphate dipotassium is a sugar intermediate in the glycolysis pathway and the pentose phosphate pathway. D-Fructose 6-phosphate dipotassium can be used to study Lewy body dementia .

D-Fructose 6-phosphate dipotassium

Biochemical Assay Reagents

D-Fructose 6-phosphate dipotassium is an endogenous metabolite in saliva that affects cell growth and autophagy; it can be hydrolyzed by Fructose-1,6-bisphosphatase (FBPase). D-Fructose 6-phosphate dipotassium can be converted into D-glucose 6-phosphate (HY-112537) by the action of phosphoglucose isomerase. D-Fructose 6-phosphate dipotassium is a sugar intermediate in the glycolysis pathway and the pentose phosphate pathway. D-Fructose 6-phosphate dipotassium can be used to study Lewy body dementia .

Art. -Nr.	Produktname	Category	Target	Chemical Structure

HY-W011184

6-Phosphogluconic acid trisodium	Classification of Application Fields Ketones, Aldehydes, Acids Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
6-Phosphogluconic acid trisodium is a potent and competitive *phosphoglucose isomerase* (PGI) inhibitor with K_i*s of 48 μM for glucose* 6-phosphate and 42 μM for fructose 6-phosphate. 6-Phosphogluconic acid trisodium is an endogenous metabolite .

HY-112537

D-Glucose 6-phosphate 4 Publications Verification	Structural Classification Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite mTOR
D-Glucose 6-phosphate is a key central node metabolite in glucose metabolism. It serves as the initiating metabolite for glycolysis and the pentose phosphate pathway, as well as a substrate for glycogen synthesis. D-Glucose 6-phosphate acts as a metabolic stress signal, which activates the mTOR pathway to promote protein synthesis, especially when phosphoglucose isomerase (PGI) is inhibited, thereby participating in cardiac remodeling processes. D-Glucose 6-phosphate can be used in research related to non-insulin-dependent diabetes mellitus and heart failure .

HY-113514

6-Phosphogluconic acid	Natürliche Produkte Classification of Application Fields Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
6-Phosphogluconic acid is a potent and competitive *phosphoglucose isomerase* (PGI) inhibitor with K_i*s of 48 μM for glucose* 6-phosphate and 42 μM for fructose 6-phosphate. 6-Phosphogluconic acid is an endogenous metabolite .

HY-N6841

Rhodiolin 1 Publications Verification	Flavonols Flavonoids Classification of Application Fields Rhodiola rosea Linn. Crassulaceae Other Diseases Phenols Polyphenols Plants Disease Research Fields Source Classification	Glucose-6-Phosphate Isomerase (GPI) Casein Kinase Virus Protease Flavivirus PI3K Akt mTOR Apoptosis
Rhodiolin, a flavonoid, is an orally active glucose 6-phosphate isomerase (GPI) inhibitor. Rhodiolin inhibits papillary thyroid cancer (PTC) by targeting glycolysis enzyme glucose 6-phosphate isomerase GPI and suppressing PI3K/AKT/mTOR phosphorylation and induce apoptosis. Rhodiolin as a NS2B-NS3 protease inhibitor can disrupt dengue viral replication. Rhodiolin is also a potential candidate for developing anticancer strategies inhibiting CK1ε kinase. Rhodiolin can be used for the study of anti-tumor and anti-viral .

HY-W011184R

6-Phosphogluconic acid trisodium (Standard)	Ketones, Aldehydes, Acids Endogenous metabolite Source Classification	Reference Standards Endogenous Metabolite
6-Phosphogluconic acid trisodium (Standard) is the analytical standard of 6-Phosphogluconic acid trisodium (HY-W011184). This product is intended for research and analytical applications. 6-Phosphogluconic acid trisodium is a potent and competitive *phosphoglucose isomerase* (PGI) inhibitor with K_i*s of 48 μM for glucose* 6-phosphate and 42 μM for fructose 6-phosphate. 6-Phosphogluconic acid trisodium is an endogenous metabolite.

Art. -Nr.	Produktname	Chemical Structure

HY-112537S2

D-Glucose 6-phosphate-13C
D-Glucose 6-phosphate- ¹³C is ¹³C labeled D-Glucose 6-phosphate (HY-112537). D-Glucose 6-phosphate is a key central node metabolite in glucose metabolism. It serves as the initiating metabolite for glycolysis and the pentose phosphate pathway, as well as a substrate for glycogen synthesis. D-Glucose 6-phosphate acts as a metabolic stress signal, which activates the mTOR pathway to promote protein synthesis, especially when phosphoglucose isomerase (PGI) is inhibited, thereby participating in cardiac remodeling processes. D-Glucose 6-phosphate can be used in research related to non-insulin-dependent diabetes mellitus and heart failure.

D-Glucose 6-phosphate-13C

D-Glucose 6-phosphate- ¹³C is ¹³C labeled D-Glucose 6-phosphate (HY-112537). D-Glucose 6-phosphate is a key central node metabolite in glucose metabolism. It serves as the initiating metabolite for glycolysis and the pentose phosphate pathway, as well as a substrate for glycogen synthesis. D-Glucose 6-phosphate acts as a metabolic stress signal, which activates the mTOR pathway to promote protein synthesis, especially when phosphoglucose isomerase (PGI) is inhibited, thereby participating in cardiac remodeling processes. D-Glucose 6-phosphate can be used in research related to non-insulin-dependent diabetes mellitus and heart failure.

Host:	Mouse (1) Rabbit (1)
Reactivity:	Human (2)
Application:	IHC-P (2) ICC/IF (2) WB (2) FC (1) ELISA (1)
Isotype:	IgG (1)
Conjugation:	Non-conjugated (2)
Clonality:	Monoclonal (2) Recombinant (1)
Modification:	Unmodified (2)

Art. -Nr.	Compare	Produktname	Application	Reactivity	Image

HY-P85191

	AMF Antibody (YA4883) GPI; Glucose-6-phosphate isomerase; GPI; Autocrine motility factor; AMF; Neuroleukin; NLK; PhosphoGlucose isomerase; PGI; Phosphohexose isomerase; PHI; Sperm antigen 36; SA-36	WB, IHC-P, ICC/IF, ELISA	Human
	AMF Antibody (YA4883) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to AMF.

HY-P82032

	AMF Antibody (YA1777) GPI; Glucose-6-phosphate isomerase; GPI; Autocrine motility factor; AMF; Neuroleukin; NLK; PhosphoGlucose isomerase; PGI; Phosphohexose isomerase; PHI; Sperm antigen 36; SA-36	WB, IHC-P, ICC/IF, FC	Human
	AMF Antibody (YA1777) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to AMF.

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Glucose 6-phosphate isomerase

Inhibitors & Agonists

Biochemical Assay Reagents

NaturalProducts

Isotope-Labeled Compounds

Antibodies

Natural
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