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Results for "

H+-ATPase

" in MedChemExpress (MCE) Product Catalog:

By Targets:	ABA Receptor (3) Amyloid-β (2) Antibiotic (4) Apoptosis (4) Autophagy (2) Bacterial (7) Dihydroorotate Dehydrogenase (2) Endogenous Metabolite (2) Environmental Pollutants (1) ERK (1) Exosomes (4) Ferroptosis (2) Fungal (2) Glutathione Peroxidase (2) Heme Oxygenase (HO) (2) Insecticide (2) Isotope-Labeled Compounds (2) Keap1-Nrf2 (2) Na+/K+ ATPase (1) NF-κB (2) PAI-1 (2) Proton Pump (19) Ras (1) Reference Standards (3) Thrombin (2) Toll-like Receptor (TLR) (2) TRP Channel (2)
By Research Areas:	Cancer (11) Cardiovascular Disease (2) Endocrinology (4) Infection (7) Inflammation/Immunology (6) Metabolic Disease (4) Neurological Disease (2)

By Targets:

ABA Receptor (3)

Amyloid-β (2)

Antibiotic (4)

Apoptosis (4)

Autophagy (2)

Bacterial (7)

Dihydroorotate Dehydrogenase (2)

Endogenous Metabolite (2)

Environmental Pollutants (1)

ERK (1)

Exosomes (4)

Ferroptosis (2)

Fungal (2)

Glutathione Peroxidase (2)

Heme Oxygenase (HO) (2)

Insecticide (2)

Isotope-Labeled Compounds (2)

Keap1-Nrf2 (2)

Na+/K+ ATPase (1)

NF-κB (2)

PAI-1 (2)

Proton Pump (19)

Ras (1)

Reference Standards (3)

Thrombin (2)

Toll-like Receptor (TLR) (2)

TRP Channel (2)

By Research Areas:

Cancer (11)

Cardiovascular Disease (2)

Endocrinology (4)

Infection (7)

Inflammation/Immunology (6)

Metabolic Disease (4)

Neurological Disease (2)

Inhibitors & Agonists

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-100558

Bafilomycin A1 Maximum Cited Publications 802 Publications Verification BafA1	Proton Pump Autophagy Antibiotic Bacterial Apoptosis	Infection Cancer
Bafilomycin A1 (BafA1) is a specific and reversible inhibitor of vacuolar H ⁺-ATPase (V-ATPase) with IC₅₀ values of 4-400 nmol/mg. Bafilomycin A1, a macrolide antibiotic, is also used as an autophagy inhibitor at the late stage. Bafilomycin A1 blocks autophagosome-lysosome fusion and inhibits acidification and protein degradation in lysosomes of cultured cells. Bafilomycin A1 induces apoptosis .

HY-N1724

Concanamycin A 25+ Cited Publications Antibiotic X 4357B; Folimycin; X 4357B	Proton Pump Bacterial Antibiotic	Infection Inflammation/Immunology Cancer
Concanamycin A (Folimycin; Antibiotic X 4357B) is a macrolide antibiotic, a vacuolar type H ⁺-ATPase (V-ATPase) inhibitor. Concanamycin A is also an inhibitor of lysosomal acidification, can be used to T cell-mediated inflammation research ^- .

HY-100560

Abscisic acid 3 Publications Verification (S)-(+)-Abscisic acid; ABA	Environmental Pollutants Endogenous Metabolite ABA Receptor Proton Pump	Metabolic Disease
Abscisic acid ((S)-(+)-Abscisic acid), an orally active phytohormone in fruits and vegetables, is an endogenously produced mammalian hormone. Abscisic acid is a growth inhibitor and can regulate many aspects of plant growth and development. Abscisic acid inhibits proton pump (H ⁺-ATPase) and leads to the plasma membrane depolarization in a Ca ²⁺-dependent manner. Abscisic acid, a LANCL2 natural ligand, is a potent insulin-sensitizing compound and has the potential for pre-diabetes, type 2 diabetes and metabolic syndrome .

HY-17022

Esomeprazole magnesium trihydrate 1 Publications Verification (S)-Omeprazole magnesium trihydrate; (-)-Omeprazole magnesium trihydrate	Exosomes Proton Pump	Endocrinology Cancer
Esomeprazole magnesium trihydrate ((S)-Omeprazole magnesium trihydrate) is a potent and orally active H ⁺, K ⁺-ATPase inhibitor. Esomeprazole magnesium trihydrate has the potential for upper intestinal disorders and gastroesophageal reflux disease research . Esomeprazole magnesium trihydrate acts as an exosome inhibitor by blocking the exosome release via the inhibition of V-H ⁺-ATPases .

HY-17023

Esomeprazole sodium 2 Publications Verification (S)-Omeprazole sodium; (-)-Omeprazole sodium	Exosomes Proton Pump Bacterial	Endocrinology Cancer
Esomeprazole sodium ((S)-Omeprazole sodium) is a potent and orally active proton pump inhibitor. Esomeprazole reduces acid secretion through inhibition of the H ⁺, K ⁺-ATPase in gastric parietal cells. Esomeprazole acts as an exosome inhibitor by blocking the exosome release via the inhibition of V-H ⁺-ATPases . Esomeprazole has the potential for symptomatic gastroesophageal reflux disease research .

HY-B1446

Esomeprazole magnesium 2 Publications Verification (S)-Omeprazole magnesium; (-)-Omeprazole magnesium	Exosomes Proton Pump	Endocrinology Cancer
Esomeprazole magnesium ((S)-Omeprazole magnesium) is a potent and orally active H ⁺, K ⁺-ATPase inhibitor. Esomeprazole magnesium has the potential for upper intestinal disorders and gastroesophageal reflux disease research . Esomeprazole magnesium acts as an exosome inhibitor by blocking the exosome release via the inhibition of V-H ⁺-ATPases .

HY-122815

Fusicoccin Fusicoccin A	Apoptosis	Cancer
Fusicoccin (Fusicoccin A), a fungal pytotoxin, is a stabilizer of specific 14-3-3 protein-protein interactions. Fusicoccin sabilizes H ⁺-ATPase/14-3-3 cmplex in pants, maintaining the enzyme in activated state. Fusicoccin also stabilizes 14-3-3 protein interactions with binding partners containing a C-terminal 14-3-3 recognition motif (a mode 3 motif), such as ERα, GPIbα, TASK3, CTFR, and p53. Fusicoccin induces apoptosis in cancer cells and has anticancer activity .

HY-A0213A

Tiludronate disodium 1 Publications Verification Tiludronic acid disodium	Proton Pump	Inflammation/Immunology
Tiludronate (Tiludronic Acid) disodium, an orally active bisphosphonate, can act an osteoregulator. Tiludronate is used for the research of the metabolic bone disorders. Tiludronate is a potent inhibitor of the osteoclast vacuolar H(+)-ATPase. Antiresorptive and anti-inflammatory properties .

HY-N3097

Pellitorine	TRP Channel Amyloid-β Toll-like Receptor (TLR) Keap1-Nrf2 Heme Oxygenase (HO) Dihydroorotate Dehydrogenase Ferroptosis PAI-1 NF-κB ERK Proton Pump Glutathione Peroxidase Thrombin Insecticide Bacterial	Infection Cardiovascular Disease Neurological Disease Inflammation/Immunology Cancer
Pellitorine is a bioactive natural amide compound. Pellitorine can competitively antagonize the activation of TRPV1 by Capsaicin (HY-10448), thereby reducing pain signal transmission. Pellitorine improves cognitive dysfunction by upregulating the BDNF-ERK1/2-CREB and Nrf2-HO-1 pathways. Pellitorine exerts anti-inflammatory and anti-sepsis effects by inhibiting the release of high mobility group protein B1 (HMGB1) and the expression of RAGE/TLR4. Pellitorine exerts its antithrombotic effect by prolonging the clotting time, inhibiting the activity of clotting factors and thrombin. Pellitorine inhibits lipid peroxidation and resists ferroptosis by upregulating GPX4 and DHODH. Pellitorine kills Aedes aegypti mosquito larvae by inhibiting V-type H⁺-ATPase and aquaporin 4 (AaAQP4). Pellitorine exhibits anti-cancer activity (e.g., leukemia and breast cancer) and has inhibitory effects on certain bacteria .

HY-176954

RSC-1255	Proton Pump Ras Autophagy Apoptosis	Cancer
RSC-1255 is a potent and selective Vacuolar H⁺-ATPase (V-ATPase) inhibitor that directly binds the mammalian V-ATPase complex with a K_d = 23 nM. RSC-1255 exhibits preferential cytotoxicity toward KRAS-mutant cancer cells, especially KRAS ^G13D and KRAS ^G12V cells. RSC-1255 induces apoptosis and blocks lysosomal acidification, autophagy, and macropinocytosis in cancer cells. RSC-1255 can be used for the study of KRAS-driven lung and colon cancers .

HY-130173

Bafilomycin C1 1 Publications Verification	Bacterial Fungal Na+/K+ ATPase Apoptosis Antibiotic	Infection Cancer
Bafilomycin C1 is a macrolide antibiotic isolated from Streptomyces sp. Bafilomycin C1 is a potent, specific and reversible inhibitor of vacuolar-type H ⁺-ATPases (V-ATPases). Bafilomycin C1 inhibits growth of gram-positive bacteria and fungi . Bafilomycin C1 induces cell apoptosis and can be used for the study of hepatocellular carcinoma (HCC) .

HY-100560R

Abscisic acid (Standard) (S)-(+)-Abscisic acid (Standard); ABA (Standard)	Reference Standards Endogenous Metabolite Proton Pump ABA Receptor	Metabolic Disease
Abscisic acid (Standard) is the analytical standard of Abscisic acid. This product is intended for research and analytical applications. Abscisic acid ((S)-(+)-Abscisic acid), an orally active phytohormone in fruits and vegetables, is an endogenously produced mammalian hormone. Abscisic acid is a growth inhibitor and can regulate many aspects of plant growth and development. Abscisic acid inhibits proton pump (H+-ATPase) and leads to the plasma membrane depolarization in a Ca2+-dependent manner. Abscisic acid, a LANCL2 natural ligand, is a potent insulin-sensitizing compound and has the potential for pre-diabetes, type 2 diabetes and metabolic syndrome .

HY-100560S

Abscisic acid-d6 (S)-(+)-Abscisic acid-d₆; ABA-d₆	Proton Pump Isotope-Labeled Compounds ABA Receptor	Metabolic Disease
Abscisic acid-d₆ is deuterium labeled Abscisic acid. Abscisic acid inhibits proton pump (H ⁺-ATPase) .

HY-W317853

Protonstatin-1	Proton Pump	Others
Protonstatin-1 is a selective plasma membrane (PM) *H ⁺-ATPase* inhibitor (IC₅₀ of 3.9 μM) that inhibits auxin transport. Protonstatin-1 interacts with the PM H ⁺-ATPase central loop and may thus impede the functions of the N- and/or P-domain to inhibit the pump activity .

HY-162935

*V-ATPase-IN-1*	Proton Pump	Others
V-ATPase-IN-1 (Compound 3b-03) is a Vacuolar-type H ⁺-ATPases (V-ATPase) inhibitor (IC₅₀ = 194.80 μM) that can effectively target the *V-ATPase* subunit A (K_d = 0.803 μM). V-ATPase-IN-1 exhibits insecticidal activity against M. separata (LC₅₀ = 2.64 mM) and contributes to research in the development of chemical insecticides .

HY-A0213

Tiludronate Tiludronic acid	Proton Pump	Inflammation/Immunology
Tiludronate (Tiludronic Acid), an orally active bisphosphonate, can act an osteoregulator. Tiludronate is used for the research of the metabolic bone disorders. Tiludronate is a potent inhibitor of the osteoclast vacuolar H(+)-ATPase. Antiresorptive and anti-inflammatory properties .

HY-17023R

Esomeprazole sodium (Standard) (S)-Omeprazole sodium (Standard); (-)-Omeprazole sodium (Standard)	Reference Standards Exosomes Proton Pump Bacterial	Endocrinology Cancer
Esomeprazole (sodium) (Standard) is the analytical standard of Esomeprazole (sodium). This product is intended for research and analytical applications. Esomeprazole sodium ((S)-Omeprazole sodium) is a potent and orally active proton pump inhibitor. Esomeprazole reduces acid secretion through inhibition of the H ⁺, K ⁺-ATPase in gastric parietal cells. Esomeprazole acts as an exosome inhibitor by blocking the exosome release via the inhibition of V-H ⁺-ATPases . Esomeprazole has the potential for symptomatic gastroesophageal reflux disease research .

HY-A0213AS

Tiludronate-d5 sodium Tiludronic acid-d5 sodium	Isotope-Labeled Compounds Proton Pump	Inflammation/Immunology
Tiludronate-d₅ (sodium)mis the deuterium labeled Tiludronate disodium. Tiludronate (Tiludronic Acid) disodium, an orally active bisphosphonate, can act an osteoregulator. Tiludronate is used for the research of the metabolic bone disorders. Tiludronate is a potent inhibitor of the osteoclast vacuolar H(+)-ATPase. Antiresorptive and anti-inflammatory properties .

HY-125707

Concanamycin B MCH 210	Proton Pump Antibiotic	Infection
Concanamycin B is a macrolide antibiotic, which can inhibit the cavitation type *H+-ATPases, and the IC₅₀* value is 5 nM .

HY-N3097R

Pellitorine (Standard)	Reference Standards TRP Channel Amyloid-β Toll-like Receptor (TLR) Keap1-Nrf2 Heme Oxygenase (HO) Dihydroorotate Dehydrogenase Ferroptosis PAI-1 NF-κB Proton Pump Glutathione Peroxidase Thrombin Insecticide Bacterial	Infection Cardiovascular Disease Neurological Disease Inflammation/Immunology Cancer
Pellitorine (Standard) is the analytical standard of Pellitorine (HY-N3097). Pellitorine is a bioactive natural amide compound. Pellitorine can competitively antagonize the activation of TRPV1 by Capsaicin (HY-10448), thereby reducing pain signal transmission. Pellitorine improves cognitive dysfunction by upregulating the BDNF-ERK1/2-CREB and Nrf2-HO-1 pathways. Pellitorine exerts anti-inflammatory and anti-sepsis effects by inhibiting the release of high mobility group protein B1 (HMGB1) and the expression of RAGE/TLR4. Pellitorine exerts its antithrombotic effect by prolonging the clotting time, inhibiting the activity of clotting factors and thrombin. Pellitorine inhibits lipid peroxidation and resists ferroptosis by upregulating GPX4 and DHODH. Pellitorine kills Aedes aegypti mosquito larvae by inhibiting V-type H⁺-ATPase and aquaporin 4 (AaAQP4). Pellitorine exhibits anti-cancer activity (e.g., leukemia and breast cancer) and has inhibitory effects on certain bacteria.

HY-A0213B

Tiludronate disodium hemihydrate Tiludronic acid disodium hemihydrate	Proton Pump	Metabolic Disease
Tiludronate (Tiludronic Acid) disodium hemihydrate, an orally active bisphosphonate, can act an osteoregulator. Tiludronate disodium hemihydrate is used for the research of the metabolic bone disorders. Tiludronate disodium hemihydrate is a potent inhibitor of the osteoclast vacuolar H ⁺-ATPase. Antiresorptive and anti-inflammatory properties .

HY-107772

NC-1175 hydrochloride	Fungal	Infection
NC-1175 hydrochloride is an antifungal agent targeting cell membrane H ⁺-ATPase. NC-1175 hydrochloride can be used for the research of infection .

Cat. No.	Product Name	Category	Target	Chemical Structure