26 Results for "

H+-ATPase

" in MedChemExpress (MCE) Product Catalog:
Products (26)

26 Results for "H+-ATPase" in MCE Product Catalog:

885
885 Publications Verification
Cat. No.: HY-100558
CAS No.: 88899-55-2
Purity:  99.95%
Synonyms: BafA1
Bafilomycin A1 (BafA1) is a specific and reversible inhibitor of vacuolar H +-ATPase (V-ATPase) with IC50 values of 4-400 nmol/mg. Bafilomycin A1, a macrolide antibiotic, is also used as an autophagy inhibitor at the late stage. Bafilomycin A1 blocks autophagosome-lysosome fusion and inhibits acidification and protein degradation in lysosomes of cultured cells. Bafilomycin A1 induces apoptosis .
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28
28 Cited Publications
Cat. No.: HY-N1724
CAS No.: 80890-47-7
Synonyms: Antibiotic X 4357B; Folimycin; X 4357B
Concanamycin A (Folimycin; Antibiotic X 4357B) is a macrolide antibiotic, a vacuolar type H +-ATPase (V-ATPase) inhibitor. Concanamycin A is also an inhibitor of lysosomal acidification, can be used to T cell-mediated inflammation research - .
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28
28 Cited Publications
Cat. No.: HY-N1724A
CAS No.: 80890-47-7
Synonyms: Antibiotic X 4357B (purity≥70%); Folimycin (purity≥70%); X 4357B (purity≥70%)
Concanamycin A (purity≥70%) (Antibiotic X 4357B) is a macrolide antibiotic, a vacuolar type H +-ATPase (V-ATPase) inhibitor. Concanamycin A (purity≥70%) is also an inhibitor of lysosomal acidification, can be used to T cell-mediated inflammation research - .
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4
4 Cited Publications
Cat. No.: HY-100560
CAS No.: 21293-29-8
Purity:  99.64%
Synonyms: (S)​-​(+)​-​Abscisic acid; ABA
Abscisic acid ((S)-(+)-Abscisic acid), an orally active phytohormone in fruits and vegetables, is an endogenously produced mammalian hormone. Abscisic acid is a growth inhibitor and can regulate many aspects of plant growth and development. Abscisic acid inhibits proton pump (H +-ATPase) and leads to the plasma membrane depolarization in a Ca 2+-dependent manner. Abscisic acid, a LANCL2 natural ligand, is a potent insulin-sensitizing compound and has the potential for pre-diabetes, type 2 diabetes and metabolic syndrome .
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2
2 Cited Publications
Cat. No.: HY-17023
CAS No.: 161796-78-7
Synonyms: (S)-Omeprazole sodium; (-)-Omeprazole sodium
Research Areas:  

Endocrinology Cancer

Esomeprazole sodium ((S)-Omeprazole sodium) is a potent and orally active proton pump inhibitor. Esomeprazole reduces acid secretion through inhibition of the H +, K +-ATPase in gastric parietal cells. Esomeprazole acts as an exosome inhibitor by blocking the exosome release via the inhibition of V-H +-ATPases . Esomeprazole has the potential for symptomatic gastroesophageal reflux disease research .
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2
2 Cited Publications
Cat. No.: HY-B1446
CAS No.: 161973-10-0
Synonyms: (S)-Omeprazole magnesium; (-)-Omeprazole magnesium
Target:  

Exosomes Proton Pump

Research Areas:  

Endocrinology Cancer

Esomeprazole magnesium ((S)-Omeprazole magnesium) is a potent and orally active H +, K +-ATPase inhibitor. Esomeprazole magnesium has the potential for upper intestinal disorders and gastroesophageal reflux disease research . Esomeprazole magnesium acts as an exosome inhibitor by blocking the exosome release via the inhibition of V-H +-ATPases .
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1
1 Cited Publications
Cat. No.: HY-17022
CAS No.: 217087-09-7
Synonyms: (S)-Omeprazole magnesium trihydrate; (-)-Omeprazole magnesium trihydrate
Target:  

Exosomes Proton Pump

Research Areas:  

Endocrinology Cancer

Esomeprazole magnesium trihydrate ((S)-Omeprazole magnesium trihydrate) is a potent and orally active H +, K +-ATPase inhibitor. Esomeprazole magnesium trihydrate has the potential for upper intestinal disorders and gastroesophageal reflux disease research . Esomeprazole magnesium trihydrate acts as an exosome inhibitor by blocking the exosome release via the inhibition of V-H +-ATPases .
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1
1 Cited Publications
Cat. No.: HY-122815
CAS No.: 20108-30-9
Synonyms: Fusicoccin A
Fusicoccin (Fusicoccin A), a fungal pytotoxin, is a stabilizer of specific 14-3-3 protein-protein interactions. Fusicoccin sabilizes H +-ATPase/14-3-3 cmplex in pants, maintaining the enzyme in activated state. Fusicoccin also stabilizes 14-3-3 protein interactions with binding partners containing a C-terminal 14-3-3 recognition motif (a mode 3 motif), such as ERα, GPIbα, TASK3, CTFR, and p53. Fusicoccin induces apoptosis in cancer cells and has anticancer activity .
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1
1 Cited Publications
Cat. No.: HY-A0213A
CAS No.: 149845-07-8
Synonyms: Tiludronic acid disodium
Target:  

Proton Pump

Research Areas:  

Inflammation/Immunology

Tiludronate (Tiludronic Acid) disodium, an orally active bisphosphonate, can act an osteoregulator. Tiludronate is used for the research of the metabolic bone disorders. Tiludronate is a potent inhibitor of the osteoclast vacuolar H(+)-ATPase. Antiresorptive and anti-inflammatory properties .
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1
1 Cited Publications
Cat. No.: HY-130173
CAS No.: 88979-61-7
Purity:  ≥99.0%
Bafilomycin C1 is a macrolide antibiotic isolated from Streptomyces sp. Bafilomycin C1 is a potent, specific and reversible inhibitor of vacuolar-type H +-ATPases (V-ATPases). Bafilomycin C1 inhibits growth of gram-positive bacteria and fungi . Bafilomycin C1 induces cell apoptosis and can be used for the study of hepatocellular carcinoma (HCC) .
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Cat. No.: HY-N3097
CAS No.: 18836-52-7
Pellitorine is a bioactive natural amide compound. Pellitorine can competitively antagonize the activation of TRPV1 by Capsaicin (HY-10448), thereby reducing pain signal transmission. Pellitorine improves cognitive dysfunction by upregulating the BDNF-ERK1/2-CREB and Nrf2-HO-1 pathways. Pellitorine exerts anti-inflammatory and anti-sepsis effects by inhibiting the release of high mobility group protein B1 (HMGB1) and the expression of RAGE/TLR4. Pellitorine exerts its antithrombotic effect by prolonging the clotting time, inhibiting the activity of clotting factors and thrombin. Pellitorine inhibits lipid peroxidation and resists ferroptosis by upregulating GPX4 and DHODH. Pellitorine kills Aedes aegypti mosquito larvae by inhibiting V-type H⁺-ATPase and aquaporin 4 (AaAQP4). Pellitorine exhibits anti-cancer activity (e.g., leukemia and breast cancer) and has inhibitory effects on certain bacteria .
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Cat. No.: HY-176954
CAS No.: 2171015-78-2
Research Areas:  

Cancer

RSC-1255 is a potent and selective Vacuolar H⁺-ATPase (V-ATPase) inhibitor that directly binds the mammalian V-ATPase complex with a Kd = 23 nM. RSC-1255 exhibits preferential cytotoxicity toward KRAS-mutant cancer cells, especially KRAS G13D and KRAS G12V cells. RSC-1255 induces apoptosis and blocks lysosomal acidification, autophagy, and macropinocytosis in cancer cells. RSC-1255 can be used for the study of KRAS-driven lung and colon cancers .
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Cat. No.: HY-100560R
CAS No.: 21293-29-8
Synonyms: (S)​-​(+)​-​Abscisic acid (Standard); ABA (Standard)
Abscisic acid (Standard) is the analytical standard of Abscisic acid. This product is intended for research and analytical applications. Abscisic acid ((S)-(+)-Abscisic acid), an orally active phytohormone in fruits and vegetables, is an endogenously produced mammalian hormone. Abscisic acid is a growth inhibitor and can regulate many aspects of plant growth and development. Abscisic acid inhibits proton pump (H+-ATPase) and leads to the plasma membrane depolarization in a Ca2+-dependent manner. Abscisic acid, a LANCL2 natural ligand, is a potent insulin-sensitizing compound and has the potential for pre-diabetes, type 2 diabetes and metabolic syndrome .
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Cat. No.: HY-100560S
CAS No.: 721948-65-8
Purity:  98.69%
Synonyms: (S)​-​(+)​-​Abscisic acid-d6; ABA-d6
Abscisic acid-d6 is deuterium labeled Abscisic acid. Abscisic acid inhibits proton pump (H +-ATPase) .
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Cat. No.: HY-W317853
CAS No.: 521972-99-6
Target:  

Proton Pump

Research Areas:  

Others

Protonstatin-1 is a selective plasma membrane (PM) H +-ATPase inhibitor (IC50 of 3.9 μM) that inhibits auxin transport. Protonstatin-1 interacts with the PM H +-ATPase central loop and may thus impede the functions of the N- and/or P-domain to inhibit the pump activity .
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Cat. No.: HY-162935
CAS No.: 1243603-61-3
Target:  

Proton Pump

Research Areas:  

Others

V-ATPase-IN-1 (Compound 3b-03) is a Vacuolar-type H +-ATPases (V-ATPase) inhibitor (IC50 = 194.80 μM) that can effectively target the V-ATPase subunit A (Kd = 0.803 μM). V-ATPase-IN-1 exhibits insecticidal activity against M. separata (LC50 = 2.64 mM) and contributes to research in the development of chemical insecticides .
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Cat. No.: HY-A0213
CAS No.: 89987-06-4
Synonyms: Tiludronic acid
Target:  

Proton Pump

Research Areas:  

Inflammation/Immunology

Tiludronate (Tiludronic Acid), an orally active bisphosphonate, can act an osteoregulator. Tiludronate is used for the research of the metabolic bone disorders. Tiludronate is a potent inhibitor of the osteoclast vacuolar H(+)-ATPase. Antiresorptive and anti-inflammatory properties .
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Cat. No.: HY-17023R
CAS No.: 161796-78-7
Synonyms: (S)-Omeprazole sodium (Standard); (-)-Omeprazole sodium (Standard)
Esomeprazole (sodium) (Standard) is the analytical standard of Esomeprazole (sodium). This product is intended for research and analytical applications. Esomeprazole sodium ((S)-Omeprazole sodium) is a potent and orally active proton pump inhibitor. Esomeprazole reduces acid secretion through inhibition of the H +, K +-ATPase in gastric parietal cells. Esomeprazole acts as an exosome inhibitor by blocking the exosome release via the inhibition of V-H +-ATPases . Esomeprazole has the potential for symptomatic gastroesophageal reflux disease research .
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Cat. No.: HY-A0213AS
Synonyms: Tiludronic acid-d5 sodium
Tiludronate-d5 (sodium)mis the deuterium labeled Tiludronate disodium. Tiludronate (Tiludronic Acid) disodium, an orally active bisphosphonate, can act an osteoregulator. Tiludronate is used for the research of the metabolic bone disorders. Tiludronate is a potent inhibitor of the osteoclast vacuolar H(+)-ATPase. Antiresorptive and anti-inflammatory properties .
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Cat. No.: HY-125707
CAS No.: 81552-33-2
Synonyms: MCH 210
Concanamycin B is a macrolide antibiotic, which can inhibit the cavitation type H+-ATPases, and the IC50 value is 5 nM .
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