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HIV-1 reverse transcriptase

" in MedChemExpress (MCE) Product Catalog:

By Targets:	HIV (223) HIV Integrase (7) HIV Protease (8) Reverse Transcriptase (150) Antibiotic (2) Apoptosis (9) Autophagy (16) Bacterial (2) Carbonic Anhydrase (3) Cytochrome P450 (3) Dipeptidyl Peptidase (1) DNA/RNA Synthesis (15) Drug Derivative (1) Drug Intermediate (4) Drug Metabolite (3) EGFR (1) Endogenous Metabolite (6) Environmental Pollutants (1) Fluorescent Dye (3) Fungal (4) HBV (3) HCV (3) Isotope-Labeled Compounds (16) MMP (2) NOD-like Receptor (NLR) (4) Nucleoside Antimetabolite/Analog (10) Opioid Receptor (1) Parasite (7) Phosphodiesterase (PDE) (1) PKC (1) Potassium Channel (2) Pyroptosis (1) Reference Standards (22) RSV (3) SARS-CoV (2) Telomerase (1)
By Research Areas:	Cancer (32) Cardiovascular Disease (2) Endocrinology (2) Infection (225) Inflammation/Immunology (21) Metabolic Disease (2) Neurological Disease (5)
Click Chemistry:	Azide (6) Alkynes (5)
Oligonucleotides:	Nucleotide Analogs (1) Nucleoside Analogs (3) Aptamers (1) Inosine (1) Cytidine (2)

238

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

Natural
Products

Isotope-Labeled Compounds

Click Chemistry

Oligonucleotides

Targets Recommended: Reverse Transcriptase HIV Integrase HIV HIV Protease

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-10572

Efavirenz Maximum Cited Publications 17 Publications Verification DMP 266; EFV; L-743726	Reverse Transcriptase HIV Autophagy Endogenous Metabolite Parasite	Infection Cancer
Efavirenz (DMP 266) is a potent inhibitor of the wild-type **HIV-1 reverse transcriptase with a K_i of 2.93 nM and exhibits an IC₉₅** of 1.5 nM for the inhibition of HIV-1 replicative spread in cell culture .

HY-15232

Tenofovir alafenamide 10+ Cited Publications GS-7340	HIV Reverse Transcriptase	Infection Cancer
Tenofovir alafenamide (GS-7340) is an investigational oral proagent of Tenofovir. Tenofovir is a *HIV-1* nucleotide reverse transcriptase inhibitor.

HY-10570

Nevirapine 5+ Cited Publications BI-RG 587; NSC 641530; NVP	HIV Reverse Transcriptase Parasite	Infection Cancer
Nevirapine is a non-nucleoside inhibitor of *HIV-1* reverse transcriptase used to treat and prevent HIV/AIDS; with a K_i of 270 μM .

HY-16767

Doravirine 10+ Cited Publications MK-1439	HIV Reverse Transcriptase	Infection Inflammation/Immunology
Doravirine (MK-1439) is a highly specific **HIV-1 nonnucleoside reverse transcriptase inhibitor with IC₅₀s of 4.5 nM, 5.5 nM and 6.1 nM against the wild type and K103N and Y181C reverse transcriptase** mutants, respectively .

HY-15232A

Tenofovir alafenamide fumarate 10+ Cited Publications GS-7340 fumarate	HIV Reverse Transcriptase	Infection Cancer
Tenofovir alafenamide fumarate (GS-7340 fumarate) is an investigational oral proagent of Tenofovir. Tenofovir is a *HIV-1* nucleotide reverse transcriptase inhibitor.

HY-147411

Ulonivirine MK-8507	Reverse Transcriptase HIV	Infection
Ulonivirine is an orally active non-nucleoside *HIV-1* reverse transcriptase inhibitor that binds to the classical non-nucleoside reverse transcriptase inhibitor hydrophobic binding pocket adjacent to the polymerase active site of **HIV-1 reverse transcriptase. Ulonivirine can be used in studies related to HIV-1** infection .

HY-N0165

Methyl-Hesperidin	HIV Reverse Transcriptase	Cardiovascular Disease Infection Inflammation/Immunology
Methyl-Hesperidin is a glycoside compound. Methyl-Hesperidin has hypotensive, coronary dilating, smooth muscle relaxing, capillary stabilizing, choleretic, and anti-ulcer activities. Methyl-Hesperidin act as a competitive substrate to inhibit **HIV-1 reverse transcriptase** activity. Methyl-Hesperidin potentiates coronary dilating actions of adenine nucleotides and 3'-AMP, enhances depressant action on isolated atria, and prolongs adenosine- and ATP-induced heart block in guinea pigs .

HY-15232B

Tenofovir alafenamide hemifumarate 10+ Cited Publications GS-7340 hemifumarate	HIV Reverse Transcriptase	Infection Cancer
Tenofovir alafenamide hemifumarate (GS-7340 hemifumarate) is an investigational oral proagent of Tenofovir. Tenofovir is a *HIV-1* nucleotide reverse transcriptase inhibitor.

HY-10571A

Delavirdine mesylate 3 Publications Verification U 90152 mesylate; BHAP-U 90152 mesylate	HIV Reverse Transcriptase	Infection
Delavirdine (U 90152) mesylate is a potent, highly specific and orally active non-nucleoside reverse transcriptase inhibitor (NNRTI). Delavirdine mesylate selectively inhibits HIV-1 reverse transcriptase (RT) (IC₅₀=0.26 μM) over DNA polymerase α (IC₅₀=440 μM) and polymerase δ (IC₅₀>550 μM). Delavirdine mesylate is an inhibitor of HIV-1 replication and can can be used for the study of AIDs .

HY-10571

Delavirdine 3 Publications Verification U 90152; BHAP-U 90152	HIV Reverse Transcriptase	Infection
Delavirdine (U 90152) is a potent, highly specific and orally active non-nucleoside reverse transcriptase inhibitor (NNRTI). Delavirdine selectively inhibits HIV-1 reverse transcriptase (RT) (IC₅₀=0.26 μM) over DNA polymerase α (IC₅₀=440 μM) and polymerase δ (IC₅₀>550 μM). Delavirdine is an inhibitor of HIV-1 replication and can can be used for the study of AIDs .

HY-N2571

Corydine	Reverse Transcriptase HIV Opioid Receptor	Infection Neurological Disease Cancer
Corydine is a *HIV-1* reverse transcriptase inhibitor and μ-opioid receptor (MOR) agonist, with an IC₅₀ of 356.7 μg/mL against HIV-1 reverse transcriptase, an EC₅₀ of 0.51 μM for MOR, and a K_i of 2.82 μM for MOR. Corydine produces antinociceptive effects by inhibiting acetic acid-induced writhing behavior in a MOR-dependent manner. Corydine inhibits the proliferation of cancer cells, mitogen-stimulated lymphocytes and IL-2-dependent cells. Corydine can be used in studies related to human immunodeficiency virus infection, visceral pain, leukemia, melanoma, bladder cancer and colon adenocarcinoma .

HY-14266

Dapivirine 2 Publications Verification TMC120; R147681	HIV Reverse Transcriptase Apoptosis Autophagy	Infection
Dapivirine (TMC120), the prototype of diarylpyrimidines (DAPY), is an orally active and *nonnucleoside reverse* transcriptase inhibitor (NRTI)*. Dapivirine (TMC120) binds directly to HIV-1* reverse transcriptase. Dapivirine (TMC120) regulates autophagy and induced Akt, Bad and SAPK/JNK activations .

HY-B1408

Salicylanilide 5 Publications Verification 2-Hydroxybenzanilide	Environmental Pollutants HIV Integrase HIV	Infection
Salicylanilide demonstrates a wide range of biological activities including antiviral potency which can inhibit HIV virus by targeting HIV-1 integrase or **reverse transcriptase**.

HY-15355

Loviride R 89439	Reverse Transcriptase HIV	Infection
Loviride (R 89439) is a non-nucleoside reverse transcriptase inhibitor (NNRTI), with an IC₅₀ of 0.3 µM for **reverse transcriptase from HIV-1*. Loviride (R 89439) inhibits HIV-1, HIV*-2 and SIV replication in MT-4 cells .

HY-W003486

5,7-Dichloropyrazolo[1,5-a]pyrimidine	Phosphodiesterase (PDE)	Neurological Disease Cancer
5,7-Dichloropyrazolo[1,5-a]pyrimidine is a PDE10A inhibitor with a K_i of 24 μM. 5,7-Dichloropyrazolo[1,5-a]pyrimidine serves as a key intermediate in the synthesis of 5,7-disubstituted pyrazolo[1,5-a]pyrimidine derivatives (HIV-1 non-nucleoside reverse transcriptase inhibitors). 5,7-Dichloropyrazolo[1,5-a]pyrimidine can be used for the research of schizophrenia .

HY-W325699

HIV-1 inhibitor-48	HIV Reverse Transcriptase	Infection
HIV-1 inhibitor-48 (compound 13o) is a novel non-nucleoside reverse transcriptase inhibitor (NNRTI) and exhibits anti-HIV-1 activity .

HY-19509

IQP-0528	Reverse Transcriptase HIV	Infection
IQP-0528 is a highly potent *nonnucleoside reverse* transcriptase inhibitor** (NNRTI). IQP-0528 shows nanomolar activity against both HIV-1 and HIV-2, with EC₅₀s of 0.2 nM and 100 nM, respectively .

HY-134851

HIV-1 inhibitor-6 1 Publications Verification	HIV	Infection
HIV-1 inhibitor-6 (compound 9), a diheteroarylamide-based compound, is a potent HIV-1 pre-mRNA alternative splicing inhibitor. HIV-1 inhibitor-6 blocks HIV replication. HIV-1 inhibitor-6 is active against wild-type HIV-1IIIB (subtype B, X4-tropic) and HIV-1 97USSN54 (subtype A, R5-tropic) with EC₅₀s of 0.6 μM and 0.9 μM, respectively. HIV-1 inhibitor-6 inhibits HIV strains resistant to agents targeting HIV reverse transcriptase, protease, integrase, and coreceptor CCR5 with EC₅₀s ranging from 0.9 to 1.5 μM .

HY-148642

12-Hydroxynevirapine 12-hydroxy-NVP; 12-OH-NVP	Drug Metabolite	Infection
12-Hydroxynevirapine (12-hydroxy-NVP; 12-OH-NVP) is a major oxidative metabolite of Nevirapine (HY-10570). Nevirapine is a non-nucleoside reverse transcriptase inhibitor indicated for the HIV-1 infections. Nevirapine causes idiosyncratic hepatotoxicity and mild-to-severe skin rashes. 12-Hydroxynevirapine, a non-reactive metabolite, can be bioactivated by sulphotransferases (SULTs) in the liver and skin, yielding the reactive species 12-Sulphoxy-nevirapine .

HY-106958

Talviraline HBY 097	HIV Reverse Transcriptase	Infection
Talviraline is a non-nucleoside reverse transcriptase (NNRT) inhibitor that is primarily used to inhibit the replication of human immunodeficiency virus type 1 (HIV-1). Talviraline inhibits the viral replication process by binding to a specific site of HIV-1 reverse transcriptase (RT). Talviraline can be used to study the potential countermeasures and safety of HIV-1 infection .

HY-100079

9-Propenyladenine Mutagenic impurity of tenofovir disoproxil	Drug Intermediate	Infection
9-Propenyladenine is a mutagenic impurity in tenofovir disoproxil fumarate. Tenofovir is an antiretroviral agent known as nucleotide analogue reverse transcriptase inhibitors, which block reverse transcriptase, a crucial virus enzyme in HIV-1 and HBV.

HY-114634

Mesoxalate Ketomalonic acid; Mesoxalic acid; Oxomalonic acid	HIV	Infection
Mesoxalate (Ketomalonic acid) a dicarboxylic acid and a ketonic acid which blocks HIV-1 reverse transcriptase (RT), with the IC₅₀ of 2.2 μM .

HY-N1034

12-Oxocalanolide A (±)-12-Oxocalanolide A	HIV	Infection
12-Oxocalanolide A (compound 6) is a potent inhibitor of reverse transcriptase from human immunodeficiency virus type 1 (HIV-1) with an IC₅₀ and EC₅₀ of 2.8 and 12 μM, respectively. 12-Oxocalanolide A is the analogue of Calanolide .

HY-122482

β-Rubromycin	HIV Reverse Transcriptase Telomerase Bacterial	Infection Metabolic Disease Cancer
β-Rubromycin, a quinone antibacterial agent, is a selective **HIV-1 reverse transcriptase inhibitor with a K_i of 0.27 μM. β-Rubromycin is a potent telomerase inhibitor with an IC₅₀ of 3 μM. β-Rubromycin inhibits the proliferation of both K-562 and HeLa cells with IC₅₀** values of 19.5 µM and 22.7 µM, respectively .

HY-152161

HIV-1 inhibitor-51	HIV Reverse Transcriptase	Infection
HIV-1 inhibitor-51, a *non-nucleoside reverse* transcriptase inhibitor (NNRTI), exhibits outstanding antiviral activity against WT HIV-1 (IIIB)** and a panel of mutant strains. HIV-1 inhibitor-51 has high binding affinity (K_D=2.50 μM) and inhibitory activity (IC₅₀=0.03 μM) to WT HIV-1 RT. HIV-1 inhibitor-51 has EC₅₀s of 2.22-53.3 nM for mutant strains (L100I, K103N, Y181C, Y188L, E138K, F227L + V106A, RES056) .

HY-152160

HIV-1 inhibitor-50	HIV Reverse Transcriptase	Infection
HIV-1 invistor-50 is a non-nucleoside **reverse transcriptase** inhibitor (NNRTI) that targets HIV-1 reverse transcriptase (RT) (IC₅₀=50 nM). HIV-1 inhibitor-50 shows significant antiviral activity, with EC₅₀s of 2.22-53.3nM against HIV-1 IIIB and its mutant strains .

HY-100079A

(Z)-9-Propenyladenine (Z)-Mutagenic Impurity of Tenofovir Disoproxil	HIV	Infection
(Z)-9-Propenyladenine is a mutagenic impurity in tenofovir disoproxil fumarate. Tenofovir is an antiretroviral agent known as nucleotide analogue reverse transcriptase (NtART) inhibitor, which blocks reverse transcriptase, a crucial virus enzyme in HIV-1 and HBV.

HY-162461

HIV-1 inhibitor-66	Reverse Transcriptase HIV	Infection
HIV-1 inhibitor-66 is an orally active non-nucleoside reverse transcription inhibitor (NNRTI). HIV-1 inhibitor-66 shows inhibitory activity against wild-type **HIV-1 reverse transcriptase with an IC₅₀** of 40 nM .

HY-122935

Nigranoic acid	HIV Reverse Transcriptase	Infection
Nigranoic acid is a triterpenoid separated from Schisandra chinensis. Nigranoic acid inhibits **HIV-1 reverse transcriptase**. Nigranoic acid exhibits protective effects on brain through PARP/AIF signaling pathway in cerebral ischemia-reperfusion animal model .

HY-175351

HIV-1-IN-83	HIV Reverse Transcriptase	Infection
HIV-1-IN-83 (Compound 18E) is a *HIV-1* non-nucleoside reverse transcriptase inhibitor with an IC₅₀ of 0.45 μM for wild-type HIV-1 non-nucleoside reverse transcriptase. HIV-1-IN-83 has potent antiviral activity against both HIV-1 wild-type and mutant strains and improves antidrug resistance for Y188L and RES056 mutant strains. HIV-1-IN-83 has no significant toxicity up to 11.088 μM .

HY-15353

Emivirine MKC-442	HIV	Infection Inflammation/Immunology
Emivirine (MKC-442) is a non-nucleoside reverse transcriptase inhibitors (NNRTIs) with K_i values of 0.20 and 0.01 μM for dTTP- and dGTP-dependent DNA or RNA polymerase activity, respectively. Emivirine displays potent and selective anti-human immunodeficiency virus type 1 (HIV-1) activity .

HY-105268

AzddMeC CS-92	HIV Reverse Transcriptase Nucleoside Antimetabolite/Analog	Infection
AzddMeC (CS-92) is an antiviral nucleoside analogue and a potent potent, selective and orally active **HIV-1 reverse transcriptase** and HIV-1 replication inhibitor. In *HIV-1*-infected human PBM cells and *HIV-1*-infected human macrophages, the EC₅₀ values of AzddMeC are 9 nM and 6 nM, respectively . AzddMeC is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-P11158

Gymnin	Fungal HIV Reverse Transcriptase	Infection Cancer
Gymnin is a defensin-like antifungal peptide. Gymnin has significant antifungal activities against phytopathogenic and mycotoxigenic fungi. Gymnin inhibits HIV-1 reverse transcriptase with an IC₅₀ of 200 μM and the proliferation of tumor cells. Gymnin has a weak mitogenic activity toward murine splenocytes. Gymnin can be used for plant disease treatments research .

HY-174303

NNRT-IN-9	HIV Reverse Transcriptase	Infection
NNRT-IN-9 (Compound EG28) is a *non-nucleoside reverse* transcriptase (NNRT)** inhibitor. NNRT-IN-9 has potent antiviral and anti-resistance activity against wild-type (WT) HIV-1 and various clinically relevant mutations (E138K and K103N + Y181C) with EC₅₀s of 55, 67 and 3910 nM, respectively. NNRT-IN-9 can be used for acquired immune deficiency syndrome (AIDS) research .

HY-19869

VRX-480773	HIV Reverse Transcriptase	Infection
VRX-480773 is an efficient non-nucleoside reverse transcriptase inhibitor (NNRTI), used for *HIV* infection. VRX-480773 has high specificity for *HIV-1, with an EC₅₀* for wild-type HIV-1 being 0.14 nM. VRX-480773 does not inhibit HIV-2, HBV or HCV, and has no effect on human DNA polymerase α/β. VRX-480773 retains inhibitory activity against Efavirenz (HY-10572) resistant strains, with EC₅₀s mostly < 1 nM. VRX-480773 can be used for research on AIDS .

HY-130241

Reverse transcriptase-IN-1	HIV	Infection
Reverse transcriptase-IN-1 (Compound 12z), a diarylbenzopyrimidine (DABP) analogue, is a potent, orally active **HIV-1 nonnucleoside reverse transcriptase** inhibitor. Reverse transcriptase-IN-1 has antiviral activity with EC₅₀ values of 3.4 nM, 4.3 nM and 3.6 nM for HIV-1 III_B, E138K and K103N mutants, respectively. Reverse transcriptase-IN-1 also has an IC₅₀of 13.7 nM against HIV-1 reverse transcriptase enzyme .

HY-118632

BILR 355	Reverse Transcriptase HIV	Infection
BILR 355 is a second-generation nonnucleoside **reverse transcriptase inhibitor (NNRTI). BILR 355 is highly specific toward HIV-1 reverse transcriptase** (RT). BILR 355 can be used for HIV infections research .

HY-159984

HIV-1 inhibitor-78	HIV	Infection
HIV-1 inhibitor-78 (compound 15f) is a potent and broad-spectrum non-nucleoside reverse transcriptase inhibitor, with an EC₅₀ of 3 nM for wild-type HIV-1. HIV-1 inhibitor-78 can be used for the research of HIV infection .

HY-15355R

Loviride (Standard) R 89439 (Standard)	Reverse Transcriptase HIV Reference Standards	Infection
Loviride (Standard) is the analytical standard of Loviride. This product is intended for research and analytical applications. Loviride (R 89439) is a non-nucleoside reverse transcriptase inhibitor (NNRTI), with an IC50 of 0.3 μM for reverse transcriptase from HIV-1. Loviride (R 89439) inhibits HIV-1, HIV-2 and SIV replication in MT-4 cells .

HY-163110

NNRT-IN-2	HIV Reverse Transcriptase	Infection
NNRT-IN-2 (compound 7w) is an orally available non-nucleoside reverse transcriptase inhibitor (NNRTI) with broad inhibitory effects on wild-type *HIV-1* and mutant strains. NNRT-IN-2 inhibits HIV-1 reverse transcriptase with an EC₅₀ of 22 nM. NNRT-IN-2 is insensitive to CYP and hERG and has good safety and pharmacokinetic characteristics .

HY-15354

TSAO-T	Reverse Transcriptase HIV	Infection
TSAO-T is a **HIV-1 reverse transcriptase inhibitor. TSAO-T can be used in the research of HIV** infection .

HY-137613C

Rp-TTPαS tetrasodium	HIV	Infection
Rp-TTPαS (tetrasodium) is the Rp-isomer of TTPαS (tetrasodium). Rp-TTPαS (tetrasodium) incorporate with HIV-1 reverse transcriptase (HIV-1 RT) with HIV-1 RT with large phosphorothioate elemental effects .

HY-168476

BRN3OMe	HIV	Infection
BRN3OMe is a potent **HIV-1 reverse transcriptase** inhibitor. BRN3OMe has the potential for the research of antiviral agent .

HY-105249

RDEA 806	HIV Reverse Transcriptase	Infection
RDEA 806 is an orally active non-nucleoside **reverse transcriptase** inhibitor (NNRTI) that exhibits potent in vitro inhibitory activity against both wild-type *HIV-1* (EC₅₀ = 3.05 nM) and NNRTI-resistant *HIV-1* .

HY-105386

HI-280	HIV Reverse Transcriptase	Infection
HI-280 is a human immunodeficiency virus type 1 (HIV-1) **reverse transcriptase** inhibitor. HI-280 can be used for the research of infection .

HY-138592

7-Deaza-2',3'-dideoxyguanosine 7-Deaza-ddG	HIV	Infection
7-Deaza-2',3'-dideoxyguanosine (7-Deaza-ddG) is a 2′,3′-dideoxynucleoside 5′-triphosphate, which can inhibit **HIV-1 reverse transcriptase with a K_i** of 25 nM .

HY-19162

Thiazolobenzimidazole NSC-625487	Reverse Transcriptase HIV	Infection
Thiazolobenzimidazole (NSC-625487) is a highly potent nonnucleoside **HIV-1 reverse transcriptase** inhibitor. Thiazolobenzimidazole inhibits HIV-induced cell killing and viral replication in a variety of human cell lines .

HY-19925

AIC-292	HIV	Infection
AIC-292 is a potent and selective inhibitor of HIV-1 nonnucleoside reverse transcriptase. AIC-292 inhibits wild-type HIV-1 laboratory strains at low nanomolar concentrations. AIC-292 displays potent antiviral in vivo efficacy in a mouse xenograft model. AIC-292 has the potential for the research of HIV-1 infection .

HY-152233

Reverse transcriptase-IN-4	HIV	Infection
Reverse transcriptase-IN-4 (compound F10) is a potent and selective non-nucleoside reverse transcriptase (NNRT) inhibitor with an EC₅₀ value of 0.053 μM for wild-type HIV-1 and an EC₅₀ value of 0.26 μM for HIV-1 mutant E138K . Reverse transcriptase-IN-4 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-152200

HIV-1 inhibitor-53	HIV Protease Reverse Transcriptase	Infection Inflammation/Immunology
HIV-1 inhibitor-53 is a dual HIV-1 protease and reverse transcriptase inhibitor. HIV-1 inhibitor-53 inhibits HIV-1 protease (PR) and reverse transcriptase (RT) activity with IC₅₀ values of 1.93 nM and 2.35 μM, respectively. HIV-1 inhibitor-53 can be used for the research of acquired immune deficiency syndrome (AIDS) .

Cat. No.	Product Name	Type

HY-142028A

Acyclovir triphosphate sodium (100 mM) AcycloGTP sodium (100 mM)	Biochemical Assay Reagents
Acyclovir triphosphate (Synonyms: AcycloGTP) sodium is a Acyclovir (HY-17422) derivative that competitively inhibits viral DNA polymerase by acting as an analog to deoxyguanosine triphosphate (dGTP). Acyclovir triphosphate (sodium) (100 mM) is an inhibitor of **HIV-1 reverse transcriptase**. Acyclovir triphosphate (sodium) (100 mM) causes termination of viral DNA synthesis .

HY-W320523

ALizarin complexone dihydrate

Biochemical Assay Reagents

ALizarin complexone dihydrate is the dehydrate of Alizarin complexone (HY-121075). Alizarin complexone is a calcium-binding fluorescent dye. Alizarin complexone stains mineralized areas of bone by binding to calcium crystals. Alizarin complexone inhibits the reverse transcriptase activity of RAV-2, HIV-1, and RSV with IC₅₀ values of 3.8 μg/mL, 45 μg/mL, and 100 μg/mL, respectively. Alizarin complexone exhibits antiviral activity against HIV-1 and RSV. Alizarin complexone delays RSV-induced tumor induction in chickens .

Cat. No.	Product Name	Target	Research Area

HY-P11158

Gymnin	Fungal HIV Reverse Transcriptase	Infection Cancer
Gymnin is a defensin-like antifungal peptide. Gymnin has significant antifungal activities against phytopathogenic and mycotoxigenic fungi. Gymnin inhibits HIV-1 reverse transcriptase with an IC₅₀ of 200 μM and the proliferation of tumor cells. Gymnin has a weak mitogenic activity toward murine splenocytes. Gymnin can be used for plant disease treatments research .

HY-P11176

Coccinin	Fungal HIV	Infection
Coccinin is an antifungal peptide. Coccinin can be purified from the seeds of large scarlet runner beans. Coccinin inhibits *HIV-1* reverse transcriptase. Coccinin shows antifungal activity against M. arachidicola, F. oxysporum, P. piricola, B. cinerea, C. comatus and R. solani, with IC₅₀s of 75, 81, 89, 109, 122 and 134 μM, respectively .

HY-P5503

Pol (476-484), HIV-1 RT Epitope	HIV	Others
Pol (476-484), HIV-1 RT Epitope is a biological active peptide. (This is a reverse transcriptase (RT) epitope (Pol residues 476-484). Within HIV-1 RT the peptide appears to be the dominant HLA A0201-restricted epitope. Was used to investigate possible mechanisms behind HIV-1* escape from CTL. IV9 is the actual epitope processed and presented in HIV-1-infected cell lines.)

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-10572

Efavirenz Maximum Cited Publications 17 Publications Verification DMP 266; EFV; L-743726	Infection Natural Products Classification of Application Fields Endogenous metabolite Disease Research Fields Source Classification Cancer	Reverse Transcriptase HIV Autophagy Endogenous Metabolite Parasite
Efavirenz (DMP 266) is a potent inhibitor of the wild-type **HIV-1 reverse transcriptase with a K_i of 2.93 nM and exhibits an IC₉₅** of 1.5 nM for the inhibition of HIV-1 replicative spread in cell culture .

HY-N0365

Sennoside A 5+ Cited Publications	Infection Quinones Structural Classification Classification of Application Fields Leguminosae Anthraquinones Plants Senna alexandrina Milll Disease Research Fields Source Classification	DNA/RNA Synthesis HIV
Sennoside A is an anthraquinone glycoside found in senna (Cassia angustifolia). Sennoside A is an *HIV-1* inhibitor (IC₅₀=3.8 μM) that inhibits HIV-1 replication. Sennoside A also inhibits HIV-1 reverse transcriptase (RT)-related DNA polymerase (RDDP) and ribonuclease H (Ribonuclease H) with IC₅₀s of 1.9 μM and 5.3 μM, respectively .

HY-N0165

Methyl-Hesperidin	Structural Classification Flavonoids other families Classification of Application Fields Flavonones Phenols Polyphenols Plants Inflammation/Immunology Disease Research Fields Source Classification	HIV Reverse Transcriptase
Methyl-Hesperidin is a glycoside compound. Methyl-Hesperidin has hypotensive, coronary dilating, smooth muscle relaxing, capillary stabilizing, choleretic, and anti-ulcer activities. Methyl-Hesperidin act as a competitive substrate to inhibit **HIV-1 reverse transcriptase** activity. Methyl-Hesperidin potentiates coronary dilating actions of adenine nucleotides and 3'-AMP, enhances depressant action on isolated atria, and prolongs adenosine- and ATP-induced heart block in guinea pigs .

HY-10571

Delavirdine 3 Publications Verification U 90152; BHAP-U 90152	Infection Classification of Application Fields Disease Research Fields	HIV Reverse Transcriptase
Delavirdine (U 90152) is a potent, highly specific and orally active non-nucleoside reverse transcriptase inhibitor (NNRTI). Delavirdine selectively inhibits HIV-1 reverse transcriptase (RT) (IC₅₀=0.26 μM) over DNA polymerase α (IC₅₀=440 μM) and polymerase δ (IC₅₀>550 μM). Delavirdine is an inhibitor of HIV-1 replication and can can be used for the study of AIDs .

HY-N2571

Corydine	Infection Alkaloids Structural Classification Monophenols other families Classification of Application Fields Phenols Plants Isoquinoline Alkaloids Disease Research Fields Source Classification	Reverse Transcriptase HIV Opioid Receptor
Corydine is a *HIV-1* reverse transcriptase inhibitor and μ-opioid receptor (MOR) agonist, with an IC₅₀ of 356.7 μg/mL against HIV-1 reverse transcriptase, an EC₅₀ of 0.51 μM for MOR, and a K_i of 2.82 μM for MOR. Corydine produces antinociceptive effects by inhibiting acetic acid-induced writhing behavior in a MOR-dependent manner. Corydine inhibits the proliferation of cancer cells, mitogen-stimulated lymphocytes and IL-2-dependent cells. Corydine can be used in studies related to human immunodeficiency virus infection, visceral pain, leukemia, melanoma, bladder cancer and colon adenocarcinoma .

HY-W719041

1,6-Di-O-galloyl-β-D-glucose	Phenols Polyphenols Styphnolobium japonicum (L.) Schott Plants Fabaceae Source Classification	HIV Reverse Transcriptase
1,6-Di-O-galloyl-β-D-glucose is a compound found in the fruit of Phyllanthus emblica. 1,6-Di-O-galloyl-β-D-glucose has HIV-1 reverse transcriptase (RT) inhibitory activity with an IC50 value of 270 μM. The inhibitory mechanism of 1,6-Di-O-galloyl-β-D-glucose is competitive inhibition of the template primer and non-competitive inhibition of the substrate (dTTP). 1,6-Di-O-galloyl-β-D-glucose can be used in anti-HIV research .

HY-N16050

Ethyl salvianolate A Ethyl salvionolate A	Simple Phenylpropanols Labiatae Phenylpropanoids Plants Indigofera kirilowii Maxim. ex Palib Source Classification	HIV Reverse Transcriptase HIV Integrase HIV Protease
Ethyl salvianolate A (Ethyl salvionolate A) is an anti-HIV-1 compound that can be extracted from the roots of Salvia yunnanensis. Ethyl salvianolate A inhibits P24 antigen in HIV-1 infected MT-4 cell cultures (EC₅₀: 1.44 μg/mL). Ethyl salvianolate A inhibits HIV-1 replicative enzymes, with IC₅₀s of 56.38 μM (Reverse transcriptase), 12.03 μM (Protease), 14.54 μM (Integrase), respectively .

HY-122935

Nigranoic acid	Infection Triterpenes Classification of Application Fields Terpenoids Plants Schisandraceae Disease Research Fields Schisandra chinensis (Turcz.) Baill. Source Classification	HIV Reverse Transcriptase
Nigranoic acid is a triterpenoid separated from Schisandra chinensis. Nigranoic acid inhibits **HIV-1 reverse transcriptase**. Nigranoic acid exhibits protective effects on brain through PARP/AIF signaling pathway in cerebral ischemia-reperfusion animal model .

HY-W751002

Orthosporin (+)-Orthosporin	Structural Classification Microorganisms Coumarins Phenylpropanoids Source Classification	Endogenous Metabolite Bacterial HIV Reverse Transcriptase
Orthosporin ((+)-Orthosporin), a phytotoxic isocoumarin compound, is a microbial secondary metabolite. Orthosporin can be isolated from the endophytic fungus Lasiodiplodia tbeobromae. Orthosporin has potent antibacterial activity against B. subtilis, E. coli and P. aeruginosa. Orthosporin also has antioxidant activity against DPPH radical and antiviral activities with inhibition of **HIV-1 reverse transcriptase** activity .

HY-N16422

Mer-NF5003E	Microorganisms Terpenoids Sesquiterpenes Source Classification	HIV HIV Protease
Mer-NF5003E is a non-nucleoside reverse transcriptase inhibitor targeting HIV-1 reverse transcriptase (RT) (EC₅₀=50 μM). Mer-NF5003E exhibits inhibitory activity against wild-type HIV-1 and multiple NNRTI-resistant strains (e.g., K103N, Y181C). Mer-NF5003E is promising for research of HIV infections .

HY-10572R

Efavirenz (Standard) DMP 266 (Standard); EFV (Standard); L-743726 (Standard)	Structural Classification Natural Products Endogenous metabolite Source Classification	Reference Standards Reverse Transcriptase HIV Autophagy Endogenous Metabolite Parasite
Efavirenz (Standard) is the analytical standard of Efavirenz. This product is intended for research and analytical applications. Efavirenz (DMP 266) is a potent inhibitor of the wild-type **HIV-1 reverse transcriptase with a K_i of 2.93 nM and exhibits an IC₉₅** of 1.5 nM for the inhibition of HIV-1 replicative spread in cell culture .

HY-142074

Inophyllum B (+)-Inophyllum B	Rosaceae Coumarins Phenylpropanoids Plants Photinia serratifolia (Desf.) Kalkman Source Classification	Reverse Transcriptase HIV
Inophyllum B ((+)-Inophyllum B) is a potent *HIV* **Reverse Transcriptase inhibitor with an IC₅₀ value of 38 nM. Inophyllum B inhibits HIV-1 (IC₅₀*=1.4 μM) in vitro cell culture. Inophyllum B can be isolated from the acetone extract of the giant African snail, Achatina fulica* .

HY-N13716

Lucidenic acid O	Triterpenes Structural Classification Microorganisms Terpenoids Source Classification	DNA/RNA Synthesis HIV Reverse Transcriptase
Lucidenic acid O is a terpene compound, is a DNA polymerases inhibitor. Lucidenic lactone inhibits calf DNA polymerase-α, rat DNA polymerase-β, and **HIV-1 reverse transcriptase with IC₅₀** values of 42 μM, 99 μM, and 69 μM, respectively .

HY-N13712

Lucidenic lactone	Other Terpenoids Structural Classification Microorganisms Terpenoids Source Classification	DNA/RNA Synthesis HIV Reverse Transcriptase
Lucidenic lactone is a terpene compound, is a DNA polymerase inhibitor. Lucidenic lactone inhibits calf DNA polymerase-α, rat DNA polymerase-β, and **HIV-1 reverse transcriptase with IC₅₀** values of 42 μM, 99 μM, and 69 μM, respectively .

HY-130050

Luzopeptin A BBM-928 A	Microorganisms Antibiotics Source Classification	Antibiotic HIV
Luzopeptin A (BBM-928 A) is an actinoleukin-like antitumor antibiotic. Luzopeptin A is a bifunctional DNA intercalator which can interact with isolated DNA molecules. Luzopeptin A induces an unwinding-rewinding process of the closed superhelical PM2 DNA. Luzopeptin A is active against *HIV-1* and *HIV-2* reverse transcriptase with IC₅₀s of 7 nM and 68 nM for HIV-1 RT and HIV-2 RT, respectively .

HY-N17741

Melanochromone	Structural Classification Coumarins Phenylpropanoids Plants Moraceae Source Classification	HIV Reverse Transcriptase
Melanochromone is an **HIV-1 reverse transcriptase** inhibitor that exhibits anti-HIV-1 activity. Melanochromone can be used in research related to HIV-1 infection .

HY-N14666

Agrocybin	Natural Products Microorganisms Source Classification	Fungal HIV Reverse Transcriptase
Agrocybin is an antifungal peptide that exerts antifungal activity against several fungal species but lacks inhibitory activity against bacteria. Agrocybin attenuates the activity of **HIV-1 reverse transcriptase** .

HY-N11288

Methyl salvionolate A	Labiatae Phenols Polyphenols Plants Indigofera kirilowii Maxim. ex Palib Source Classification	HIV
Methyl salvionolate A is a potent inhibitor of *HIV-1. Methyl salvionolate A inhibits P24* antigen in HIV-1 infected MT-4 cell with an EC₅₀ of 1.62 μg/ml. Methyl salvionolate A also inhibits HIV-1 reverse transcriptase, protease and integrase with IC₅₀s of 50.58, 10.73 and 7.58 μg/ml, respectively .

HY-146364

CI-39	Structural Classification Alkaloids Cruciferae Isatis tinctoria L. Plants Indole Alkaloids Source Classification	DNA/RNA Synthesis HIV
CI-39 is an antiviral natural product. CI-39 is an NNRTI (non-nucleoside reverse transcriptase inhibit) antiviral agent with an EC₅₀ of 3.40 μM and an CC₅₀ of >30 μM for wild type HIV-1. CI-39 inhibits HIV-1 RT DNA polymerase and ribonuclease H activitiessup .

HY-N17718

Urushiol (15:3) 3-[8'(Z), 11'(Z), 14'-Pentadecatrienyl] catechol	Structural Classification Phenols Polyphenols Plants Toxicodendron vernicifluum (Stokes) F. A. Barkl. Anacardiaceae Source Classification	HIV Reverse Transcriptase
Ursolic acid (15:3) (Compound 4) is a type of resiniferatoxin compound that can be found in the leaves of the tree Rhus verniciflua. Ursolic acid (15:3) exhibits moderate inhibitory activity against HIV-1 reverse transcriptase (b **HIV-1 reverse transcriptase), with an IC₅₀** value of 55.36 μM. Ursolic acid (15:3) shows strong cytotoxicity against both PC-3 and MRC-5 cells. Ursolic acid (15:3) can be used in the research of anti-HIV-1 infection and prostate cancer .

HY-N14349

Asterriquinone ARQ; Asterriquinone SU5504	Quinones Structural Classification Alkaloids Microorganisms Benzene Quinones Indole Alkaloids Source Classification	EGFR HIV Reverse Transcriptase
Asterriquinone (ARQ), a Asterriquinone analog, is a Grb-2 binding inhibitor. Asterriquinone inhibits the Grb-2 binding activity to tyrosine phosphorylated EGFR, with an IC₅₀ of 8.37 μM. Asterriquinone is a **HIV1 reverse transcriptase inhibitor with a K_i** of 2.3 μM. Asterriquinone also inhibits Grb-7 and PLC-γ binding activities. .

HY-N17392

Artoheteronin	Structural Classification Artocarpus heterophyllus Lam. Coumarins Phenylpropanoids Plants Moraceae Source Classification	HIV Reverse Transcriptase
Artoheteronin is a prenylated coumarin found in the fruits of Artocarpus heterophyllus. Artoheteronin can inhibit **HIV-1 reverse transcriptase activity with an EC₅₀** of 0.18 μM. Artoheteronin shows anti-inflammatory activity and inhibits nitric oxide production. Artoheteronin can be used for the researches of HIV infection and inflammatory disease .

HY-182552

Soulattrolide	Structural Classification Calophyllum teysmannii Miq. Coumarins Phenylpropanoids Plants Calophyllaceae Source Classification	HIV Reverse Transcriptase DNA/RNA Synthesis
Soulattrolide is a non-nucleoside **HIV-1 reverse transcriptase (RT) inhibitor with IC₅₀** values of 0.34 µM for HIV-1 RT, 69.5 µM for E. coli RNase H, and >495 µM for human DNA polymerase β, and can be found in Calophyllum teysmannii latex. Soulattrolide can be used for the research of HIV-1 infection, pain, inflammation, and Mycobacterium tuberculosis infection .

HY-N15438

Herbacitrin	Malvaceae Structural Classification Flavanonols Flavonoids Gossypium herbaceum Linn. Plants Source Classification	HIV HIV Integrase
Herbacitrin is a **HIV-1 reverse transcriptase and integrase inhibitor with IC₅₀** values of 21.5 μM and 2.15 μM, respectively. Herbacitrin inhibits the growth of normal mouse embryonic cells, hybridoma HF cells, and ras/myc-transformed SFME cells, regulates the growth of ras-transformed SFME cells, and exhibits cytotoxic activity against hybridoma HF cells. Herbacitrin can be used in studies related to HIV-1 infection .

HY-N16888

Peruvianoside II	Apocynaceae Structural Classification Flavanonols Flavonoids Thevetia peruviana (Pers.) K. Schum. Plants Source Classification	HIV Integrase Reverse Transcriptase
Peruvianoside II is a flavanone glucoside compound. Peruvianoside II shows no inhibitory activity against both *HIV-1* reverse transcriptase and *HIV-1* integrase at concentrations below 100 μM. Peruvianoside II can be extracted from the leaves of Thevetia peruviana .

HY-136972A

GB-1a Biflavanone GB-1a	Structural Classification Flavonoids Plants Biflavones Toxicodendron vernicifluum (Stokes) F. A. Barkl. Anacardiaceae Source Classification	HIV Reverse Transcriptase
GB-1a (Biflavanone GB-1a) is a biflavanone **HIV-1 reverse transcriptase inhibitor (IC₅₀=236 μM), with an EC₅₀** of 38.0 μM for HIV-1 replication. GB-1a can block the conversion of HIV-1 genomic RNA to DNA and can be used in research related to AIDS (HIV-1 infection). GB-1a can be naturally extracted from the heartwood of Garcinia multiflora Champ .

HY-N0165R

Methyl-Hesperidin (Standard)	Structural Classification Flavonoids other families Flavonones Phenols Polyphenols Plants Source Classification	Reference Standards HIV Reverse Transcriptase
Methyl-Hesperidin (Standard) is the analytical standard of Methyl-Hesperidin (HY-N0165). This product is intended for research and analytical applications. Methyl-Hesperidin is a glycoside compound. Methyl-Hesperidin has hypotensive, coronary dilating, smooth muscle relaxing, capillary stabilizing, choleretic, and anti-ulcer activities. Methyl-Hesperidin act as a competitive substrate to inhibit **HIV-1 reverse transcriptase** activity. Methyl-Hesperidin potentiates coronary dilating actions of adenine nucleotides and 3'-AMP, enhances depressant action on isolated atria, and prolongs adenosine- and ATP-induced heart block in guinea pigs .

HY-N16872

Peruvianoside I	Apocynaceae Structural Classification Flavanonols Flavonoids Thevetia peruviana (Pers.) K. Schum. Plants Source Classification	Drug Derivative
Peruvianoside I is a natural flavonoid.

Cat. No.	Product Name	Chemical Structure

HY-16767S1

Doravirine-13C,d3
Doravirine-13C,d3 (MK-1439-13C,d3) is the deuterium labeled Doravirine (HY-16767). Doravirine (MK-1439) is a highly specific **HIV-1 nonnucleoside reverse transcriptase inhibitor with IC₅₀s of 4.5 nM, 5.5 nM and 6.1 nM against the wild type and K103N and Y181C reverse transcriptase** mutants, respectively .

HY-10572S1

Efavirenz-13C6
Efavirenz- ¹³C₆ is the ¹³C-labeled Efavirenz. Efavirenz (DMP 266) is a potent inhibitor of the wild-type HIV-1 reverse transcriptase with a K_i of 2.93 nM and exhibits an IC₉₅ of 1.5 nM for the inhibition of HIV-1 replicative spread in cell culture .

HY-10572S

Efavirenz-d5

Efavirenz-d₅ (DMP 266-d₅) is the deuterium labeled Efavirenz. Efavirenz (DMP 266) is a potent inhibitor of the wild-type HIV-1 reverse transcriptase with a K_i of 2.93 nM and exhibits an IC₉₅ of 1.5 nM for the inhibition of HIV-1 replicative spread in cell culture . Efavirenz-d₅ is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-10574S

Rilpivirine-d6
Rilpivirine-d₆ is the deuterium labeled Rilpivirine. Rilpivirine (R278474) is a potent and specific diarylpyrimidine (DAPY) non-nucleoside reverse transcriptase inhibitor (NNRTI). Rilpivirine has high antiviral activity against wild-type HIV (EC₅₀=0.4 nM) and mutant viruses (EC₅₀=0.1-2.0 nM). Rilpivirine has a high genetic barrier to resistance development of HIV .

HY-10570S

Nevirapine-d4
Nevirapine-d₄ is deuterium labeled Nevirapine. Nevirapine is a non-nucleoside inhibitor of HIV-1 reverse transcriptase used to treat and prevent HIV/AIDS; with a K_i of 270 μM .

HY-14266S

Dapivirine-d11
Dapivirine-d₁₁ is the deuterium labeled Dapivirine. Dapivirine (TMC120), the prototype of diarylpyrimidines (DAPY), is an orally active and nonnucleoside reverse transcriptase inhibitor (NRTI). Dapivirine (TMC120) binds directly to HIV-1 reverse transcriptase. Dapivirine (TMC120) regulates autophagy and induced Akt, Bad and SAPK/JNK activations .

HY-14266S1

Dapivirine-d4
Dapivirine-d₄ (TMC120-d₄) is deuterium labeled Dapivirine. Dapivirine (TMC120), the prototype of diarylpyrimidines (DAPY), is an orally active and *nonnucleoside reverse* transcriptase inhibitor (NRTI)*. Dapivirine (TMC120) binds directly to HIV-1* reverse transcriptase. Dapivirine (TMC120) regulates autophagy and induced Akt, Bad and SAPK/JNK activations .

HY-10570S1

Nevirapine-d3
Nevirapine-d₃ (BI-RG 587-d₃) is the deuterium labeled Nevirapine. Nevirapine is a non-nucleoside inhibitor of HIV-1 reverse transcriptase used to treat and prevent HIV/AIDS; with a K_i of 270 μM .

HY-10570S2

Nevirapine-d8
Nevirapine-d₈ (BI-RG 587-d₈) is deuterium labeled Nevirapine. Nevirapine is a non-nucleoside inhibitor of *HIV-1* reverse transcriptase used to treat and prevent HIV/AIDS; with a K_i of 270 μM .

HY-15232S2

Tenofovir alafenamide-d6
Tenofovir alafenamide-d₆ (GS-7340-d₆) is deuterium labeled Tenofovir alafenamide. Tenofovir alafenamide (GS-7340) is an investigational oral proagent of Tenofovir. Tenofovir is a *HIV-1* nucleotide reverse transcriptase inhibitor .

HY-W653961

Tenofovir alafenamide-d5 fumarate
Tenofovir alafenamide-d₅ fumarate (GS-7340-d₅ fumarate) is the deuterium labeled Tenofovir alafenamide fumarate (HY-15232A). Tenofovir alafenamide fumarate (GS-7340 fumarate) is an investigational oral proagent of Tenofovir. Tenofovir is a HIV-1 nucleotide reverse transcriptase inhibitor.

HY-10572BS

(Rac)-Efavirenz-d4

(Rac)-Efavirenz-d₄ is a labelled racemic Efavirenz. Efavirenz (DMP 266) is a potent inhibitor of the wild-type HIV-1 reverse transcriptase with a K_i of 2.93 nM and exhibits an IC₉₅ of 1.5 nM for the inhibition of HIV-1 replicative spread in cell culture . (Rac)-Efavirenz-d4 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-B0116S

Stavudine-d4
Stavudine-d₄ is the deuterium labeled Stavudine. Stavudine (d4T) is an orally active nucleoside reverse transcriptase inhibitor (NRTI). Stavudine has activity against HIV-1 and HIV-2. Stavudine also inhibits the replication of mitochondrial DNA (mtDNA). Stavudine reduces NLRP3 inflammasome activation and modulates Amyloid-β autophagy. Stavudine induces apoptosis .

HY-132508S

Etravirine-d8
Etravirine-d₈ is the deuterium labeled Etravirine. Etravirine (R165335) is a non-nucleoside reverse transcriptase inhibitor (NNRTI) used for the treatment of HIV .

HY-W765997

Didanosine-13C2,15N
Didanosine- ¹³C₂, ¹⁵N (2',3'-Dideoxyinosine- ¹³C₂, ¹⁵N; ddI- ¹³C₂, ¹⁵N) is the ¹³C- and ¹⁵N-labeled labeled Didanosine (HY-B0249). Didanosine (2',3'-Dideoxyinosine; ddI) is a a potent and orally active dideoxynucleoside analogue, and also is a potent nucleoside reverse transcriptase inhibitor. Didanosine shows antiretroviral activity for HIV .

HY-10574S1

Rilpivirine-13C6

Rilpivirine- ¹³C₆ (R278474- ¹³C₆) is ¹³C labeled Rilpivirine. Rilpivirine (R278474) is a potent and specific diarylpyrimidine (DAPY) non-nucleoside reverse transcriptase inhibitor (NNRTI). Rilpivirine has high antiviral activity against wild-type HIV (EC₅₀=0.4 nM) and mutant viruses (EC₅₀=0.1-2.0 nM). Rilpivirine has a high genetic barrier to resistance development of HIV .

HY-10570S3

Nevirapine-d5
Nevirapine-d₅ (BI-RG 587-d₅) is deuterium labeled Nevirapine. Nevirapine is a non-nucleoside inhibitor of *HIV-1* reverse transcriptase used to treat and prevent HIV/AIDS; with a K_i of 270 μM .

Cat. No.	Product Name		Classification

HY-19314

Azvudine Maximum Cited Publications 6 Publications Verification RO-0622; FNC		Azide
Azvudine (RO-0622) is a potent nucleoside reverse transcriptase inhibitor (NRTI), with antiviral activity on *HIV, HBV* and HCV. Azvudine exerts highly potent inhibition on HIV-1 (EC₅₀s ranging from 0.03 to 6.92 nM) and HIV-2 (EC₅₀s ranging from 0.018 to 0.025 nM). Azvudine inhibits NRTI-resistant viral strains . Azvudine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-16776

Censavudine Festinavir; BMS-986001; OBP-601		Alkynes
Censavudine (OBP-601; BMS-986001), a nucleoside analog, is a nucleoside reverse transcriptase inhibitor. Censavudine is a potent *HIV* inhibitor with EC₅₀ ranges from 30 nM to 81 nM and 450 nM to 890 nM for *HIV-2* and *HIV-1*, respectively . Censavudine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-19314A

Azvudine hydrochloride Maximum Cited Publications 6 Publications Verification RO-0622 hydrochloride; FNC hydrochloride		Azide
Azvudine (RO-0622) hydrochloride is a potent nucleoside reverse transcriptase inhibitor (NRTI), with antiviral activity on *HIV, HBV* and HCV. Azvudine hydrochloride exerts highly potent inhibition on HIV-1 (EC₅₀s ranging from 0.03 to 6.92 nM) and HIV-2 (EC₅₀s ranging from 0.018 to 0.025 nM). Azvudine hydrochloride inhibits NRTI-resistant viral strains . Azvudine (hydrochloride) is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-138561

EFdA-TP		Alkynes
EFdA-TP is a potent *nucleoside reverse* transcriptase (RT) inhibitor. EFdA-TP inhibits RT-catalyzed DNA synthesis as an effective immediate or delayed chain terminator (ICT or DCT). EFdA-TP inhibits HIV-1** RT with multiple mechanisms .

HY-138561B

EFdA-TP tetrasodium		Alkynes
EFdA-TP tetrasodium is a potent *nucleoside reverse* transcriptase (RT) inhibitor. EFdA-TP tetrasodium inhibits RT-catalyzed DNA synthesis as an effective immediate or delayed chain terminator (ICT or DCT). EFdA-TP tetrasodium inhibits HIV-1** RT with multiple mechanisms . EFdA-TP (tetrasodium) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-105268

AzddMeC CS-92		Azide
AzddMeC (CS-92) is an antiviral nucleoside analogue and a potent potent, selective and orally active **HIV-1 reverse transcriptase** and HIV-1 replication inhibitor. In *HIV-1*-infected human PBM cells and *HIV-1*-infected human macrophages, the EC₅₀ values of AzddMeC are 9 nM and 6 nM, respectively . AzddMeC is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-168476

BRN3OMe		Azide
BRN3OMe is a potent **HIV-1 reverse transcriptase** inhibitor. BRN3OMe has the potential for the research of antiviral agent .

HY-152233

Reverse transcriptase-IN-4		Azide
Reverse transcriptase-IN-4 (compound F10) is a potent and selective non-nucleoside reverse transcriptase (NNRT) inhibitor with an EC₅₀ value of 0.053 μM for wild-type HIV-1 and an EC₅₀ value of 0.26 μM for HIV-1 mutant E138K . Reverse transcriptase-IN-4 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-138561A

EFdA-TP tetraammonium		Alkynes
EFdA-TP tetraammonium is a potent *nucleoside reverse* transcriptase (RT) inhibitor. EFdA-TP tetraammonium inhibits RT-catalyzed DNA synthesis as an effective immediate or delayed chain terminator (ICT or DCT). EFdA-TP tetraammonium inhibits HIV-1** RT with multiple mechanisms . EFdA-TP (tetraammonium) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-111640

3'-Azido-3'-deoxy-5-methylcytidine		Azide
3'-Azido-3'-deoxy-5-methylcytidine (CS-92) is a potent xenotropic murine leukemia-related retrovirus (XMRV) inhibitor with a CC₅₀ of 43.5 μM in MCF-7 cells. 3'-Azido-3'-deoxy-5-methylcytidine also inhibits **HIV-1 reverse transcriptase with an EC₅₀** of 0.06 μM in peripheral blood mononuclear (PBM) cells . 3'-Azido-3'-deoxy-5-methylcytidine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-125810

4'-Ethynyl-2'-deoxyadenosine		Alkynes
4'-Ethynyl-2'-deoxyadenosine (4'-E-dA), a nucleoside reverse transcriptase (RT) inhibitor, is an antiretroviral agent which is potent against drug-resistant HIV variants, with an EC₅₀ of 98 nM in MT-4 cells for anti-HIV-1 activity . 4'-Ethynyl-2'-deoxyadenosine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Cat. No.	Product Name		Classification

HY-19314

Azvudine Maximum Cited Publications 6 Publications Verification RO-0622; FNC		Nucleoside Analogs Cytidine
Azvudine (RO-0622) is a potent nucleoside reverse transcriptase inhibitor (NRTI), with antiviral activity on *HIV, HBV* and HCV. Azvudine exerts highly potent inhibition on HIV-1 (EC₅₀s ranging from 0.03 to 6.92 nM) and HIV-2 (EC₅₀s ranging from 0.018 to 0.025 nM). Azvudine inhibits NRTI-resistant viral strains . Azvudine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-B0249

Didanosine 1 Publications Verification 2',3'-Dideoxyinosine; ddI		Nucleoside Analogs Inosine
Didanosine (2',3'-Dideoxyinosine; ddI) is a a potent and orally active dideoxynucleoside analogue, and also is a potent nucleoside reverse transcriptase inhibitor. Didanosine shows antiretroviral activity for HIV .

HY-19314A

Azvudine hydrochloride Maximum Cited Publications 6 Publications Verification RO-0622 hydrochloride; FNC hydrochloride		Nucleoside Analogs Cytidine
Azvudine (RO-0622) hydrochloride is a potent nucleoside reverse transcriptase inhibitor (NRTI), with antiviral activity on *HIV, HBV* and HCV. Azvudine hydrochloride exerts highly potent inhibition on HIV-1 (EC₅₀s ranging from 0.03 to 6.92 nM) and HIV-2 (EC₅₀s ranging from 0.018 to 0.025 nM). Azvudine hydrochloride inhibits NRTI-resistant viral strains . Azvudine (hydrochloride) is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-137697D

ddCTP trisodium solution (100 mM)		Nucleotide Analogs
ddCTP trilithium solution (100 mM) is a chain-terminating dideoxynucleotide. ddCTP trilithium can be incorporated into an extending primer strand lacking a 3'-hydroxyl group, thereby terminating primer extension, viral genome replication, and DNA synthesis. In primer extension inhibition assays, ddCTP trilithium enables discrimination of nearly identical RNAs via distinguishable extension products.

HY-177813

148.1-38m sodium		Aptamers
148.1-38m sodium, an RNA aptamer, inhibits HIV-1 reverse transcriptase (RT) and interfere with viral replication.

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