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Results for "

HeLa S3

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Antibiotic (3) Bacterial (4) Biochemical Assay Reagents (1) DNA Methyltransferase (1) DNA Stain (1) Endogenous Metabolite (1) Fluorescent Dye (1) Fungal (2) Histone Acetyltransferase (1) PKA (1) PKC (1) Polo-like Kinase (PLK) (1) Reference Standards (1) Topoisomerase (3)
By Research Areas:	Cancer (18) Cardiovascular Disease (3) Infection (6) Inflammation/Immunology (1) Metabolic Disease (1)

Inhibitors & Agonists

Fluorescent Dyes

Biochemical Assay Reagents

Peptides

Natural
Products

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-23430

TES	Biochemical Assay Reagents	Others
TES is an excellent hydrogen ion buffer. TES has characteristics such as an appropriate dissociation constant, a low metal-binding constant, and high water solubility. TES can be used in the research of mammalian cell culture, viruses, and so on .

HY-141466

Crotonyl-CoA	Endogenous Metabolite Histone Acetyltransferase	Infection Metabolic Disease Inflammation/Immunology
Crotonyl-CoA, a high-energy acyl donor, is an intermediate in the fermentation of butyric acid, and in the metabolism of lysine and tryptophan. Crotonyl-CoA is important in the metabolism of fatty acids and amino acids. Crotonyl-CoA acts as a substrate for p300’s histone crotonyltransferase activity, competing with acetyl-CoA for p300-mediated histone acylation reactions. Crotonyl-CoA regulates global and gene-specific histone crotonylation levels in cells, with cellular concentration changes altering histone crotonylation at regulatory elements of activated genes. Crotonyl-CoA serves as the substrate for crotonyl-CoA reductase/carboxylase (CCRC)-catalyzed NADPH-mediated reduction and carbon dioxide trapping to form unusual alkylmalonyl-CoA polyketide synthase extender units. Crotonyl-CoA can be used for the research of LPS-induced inflammatory response .

HY-13057

O6BTG-octylglucoside 3 Publications Verification Glucose-conjugated MGMT inhibitor	DNA Methyltransferase	Cancer
O6BTG-octylglucoside is a potent O ⁶-methylguanine-DNAmethyl-transferase (MGMT) inhibitor, with IC₅₀s of 32 nM in vitro (cell extracts) and 10 nM in HeLa S3 cells.

HY-136248

Cyanine 3 Tyramide 1 Publications Verification Tyramide-Cy3	DNA Stain Fluorescent Dye	Others
Cyanine 3 Tyramide (Tyramide-Cy3) is an orange fluorescent dye used as a reporter fluorescent substrate for horseradish peroxidase (HRP)-catalyzed deposition, which serves as a signal amplification technique in immunoassays and in situ nucleic acid hybridization .

HY-108262

UCN-02 7-epi-Hydroxystaurosporine	PKC PKA	Cancer
UCN-02 (7-epi-Hydroxystaurosporine) is a selective protein kinase C (PKC) inhibitor with a PKC IC₅₀ value of 62 nM and a PKA IC₅₀ value of 0.25 μM. UCN-02 can be produced by Streptomyces strain N-126. UCN-02 can be used for the research of breast carcinoma .

HY-101775A

9-Hydroxyellipticine hydrochloride	Topoisomerase	Cardiovascular Disease Cancer
9-Hydroxyellipticine hydrochloride is a inhibitor of Topo II and RyR. 9-Hydroxyellipticine hydrochloride exhibits antitumor, antioxidant and catecholamine-releasing activities. 9-Hydroxyellipticine hydrochloride exhibits IC₅₀ values of 1.6 μM and 1.2μM in Hela S-3 and 293T cells, respectively .

HY-N9172

Eupaglehnin C	Others	Cancer
Eupaglehnin C is a germacrane-type sesquiterpenoi. Eupaglehnin C can be isolated from the MeOH extract of Eupatorium glehni (Compositae). Eupaglehnin C has cytotoxic activity against HeLa-S3 cancer cell lines .

HY-N13976

Belactosin C	Others	Cancer
Belactosin C is found in the strain of Streptomyces sp. that inhibits HeLa S3 cells with the IC₅₀ of 200 μM .

HY-N10542

Aplyronine C	Others	Cancer
Aplyronine C is an active compound. Aplyronine C shows potent antitumor activity and has cytotoxicity against HeLa-S3 cells with an IC₅₀ values of 22 nM. Aplyronine C can be used for the research of cancer .

HY-N10541

Aplyronine B	Others	Cancer
Aplyronine B is an active compound. Aplyronine B shows potent antitumor activity and has cytotoxicity against HeLa-S3 cells with an IC₅₀ values of 2.9 nM. Aplyronine B can be used for the research of cancer .

HY-N8512

Asperfuran	Fungal	Infection
Asperfuran is an antifungal dihydrobenzofuran derivative produced by a strain of Aspergillus oryzae. Asperfuran weakly inhibits chitin synthase from Coprinus cinereus. Asperfuran shows weak cytotoxicity In HeLa S3 and L1210 cells with an IC₅₀ of 25 μg/ml .

HY-N5186

Cypemycin	Antibiotic Bacterial	Infection Cancer
Cypemycin is a linaridin antibiotic that can inhibit cancer cell activity, inhibits P388 leukemia cells with IC₅₀ of 1.3 μg/mL. Cypemycin can inhibit human tumor cells such as HeLa S3, HHCC-1, HCCS-M and Slex with IC₅₀ of >25 μg/mL .

HY-101775

9-Hydroxyellipticin	Topoisomerase	Cardiovascular Disease Cancer
9-hydroxyellipticine is an inhibitor of Topo II and RyR, exhibiting high affinity for DNA with a P_ka value of 9.8 at pH 7.4. It has antitumor, antioxidant, and catecholamine-releasing activities, with IC₅₀ values of 1.6 μM and 1.2 μM for Hela S-3 and 293T cells, respectively. It also demonstrates anticancer effects in L1210 leukemia mice .

HY-101775AR

9-Hydroxyellipticine hydrochloride (Standard)	Reference Standards Topoisomerase	Cardiovascular Disease Cancer
9-Hydroxyellipticine (hydrochloride) (Standard) is the analytical standard of 9-Hydroxyellipticine (hydrochloride). This product is intended for research and analytical applications. 9-Hydroxyellipticine hydrochloride is a inhibitor of Topo II and RyR. 9-Hydroxyellipticine hydrochloride exhibits antitumor, antioxidant and catecholamine-releasing activities. 9-Hydroxyellipticine hydrochloride exhibits IC50 values of 1.6 μM and 1.2μM in Hela S-3 and 293T cells, respectively .

HY-P10596

Lasioglossin-III	Bacterial Fungal	Infection Cancer
Lasioglossin-III is an antimicrobial peptide that can be isolated from the venom of wild bees. Lasioglossin-III has high antibacterial activity against Gram-positive and Gram-negative bacteria, antifungal activity and antitumor activity. Lasioglossin-III has certain cytotoxicity against three cancer cell lines (HeLa S3, CRC SW 480 and CCRF-CEM T) with IC₅₀ values of 4, 18 and 5 μM, respectively .

HY-N13975

Belactosin A	Others	Cancer
Belactosin A is found in the strain of Streptomyces sp. that inhibits HeLa S3 cells with the IC₅₀ of 51 μM .

HY-N14438

Furaquinocin A	Others	Cancer
Furaquinocin A can kill HeLa S3 and B16 melanoma cells, but has no antibacterial activity .

HY-N14439

Furaquinocin B	Others	Cancer
Furaquinocin B can kill HeLa S3 and B16 melanoma cells, but has no antibacterial activity .

HY-N14440

Furaquinocin C	Others	Cancer
Furaquinocin CA can kill HeLa S3 and B16 melanoma cells, but has no antibacterial activity .

HY-N14410

Clecarmycin C	Antibiotic Bacterial	Infection Cancer
Clecarmycin C is an antitumor antibiotic. Clecarmycin C shows cytotoxicity and antitumor activity. Clecarmycin C shows antimicrobial activity .

HY-N14145

Collinone	Antibiotic Bacterial	Infection
Collinone is a recombinant angular polyketide antibiotic. Collinone shows antibacterial activities for gram-positive bacterial. Collinone shows cytotoxicity .

HY-N5208

YM-216391	Others	Cancer
YM-216391 is an antitumor cyclic peptide that can be isolated from the cultured mycelium of Streptomyces nobilis JCM 4274. YM-216391 exhibits potent cytotoxic activity against a variety of human cancer cell lines and can be used in anticancer research .

HY-104023

ZK-Thiazolidinone	Polo-like Kinase (PLK)	Cancer
ZK-Thiazolidinone is an ATP-competitive Polo-like kinase 1 (Plk1) inhibitor with an IC₅₀ of 19 nM. ZK-Thiazolidinone inhibits tumor cell proliferation, induces cell cycle arrest and typical mitotic defects. ZK-Thiazolidinone impairs the recruitment of γ-tubulin and Aurora A kinase to centrosomes, resulting in failure of bipolar spindle maintenance and sister chromatid arm cohesion.\nZK-Thiazolidinone is applicable for cancer research .

Cat. No.	Product Name	Type

HY-136248

Cyanine 3 Tyramide 1 Publications Verification Tyramide-Cy3	Fluorescent Dyes
Cyanine 3 Tyramide (Tyramide-Cy3) is an orange fluorescent dye used as a reporter fluorescent substrate for horseradish peroxidase (HRP)-catalyzed deposition, which serves as a signal amplification technique in immunoassays and in situ nucleic acid hybridization .

TES	Biochemical Assay Reagents
TES is an excellent hydrogen ion buffer. TES has characteristics such as an appropriate dissociation constant, a low metal-binding constant, and high water solubility. TES can be used in the research of mammalian cell culture, viruses, and so on .

Cat. No.	Product Name	Target	Research Area

HY-P10596

Lasioglossin-III	Bacterial Fungal	Infection Cancer
Lasioglossin-III is an antimicrobial peptide that can be isolated from the venom of wild bees. Lasioglossin-III has high antibacterial activity against Gram-positive and Gram-negative bacteria, antifungal activity and antitumor activity. Lasioglossin-III has certain cytotoxicity against three cancer cell lines (HeLa S3, CRC SW 480 and CCRF-CEM T) with IC₅₀ values of 4, 18 and 5 μM, respectively .

Crotonyl-CoA	Structural Classification Natural Products Classification of Application Fields Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite Histone Acetyltransferase
Crotonyl-CoA, a high-energy acyl donor, is an intermediate in the fermentation of butyric acid, and in the metabolism of lysine and tryptophan. Crotonyl-CoA is important in the metabolism of fatty acids and amino acids. Crotonyl-CoA acts as a substrate for p300’s histone crotonyltransferase activity, competing with acetyl-CoA for p300-mediated histone acylation reactions. Crotonyl-CoA regulates global and gene-specific histone crotonylation levels in cells, with cellular concentration changes altering histone crotonylation at regulatory elements of activated genes. Crotonyl-CoA serves as the substrate for crotonyl-CoA reductase/carboxylase (CCRC)-catalyzed NADPH-mediated reduction and carbon dioxide trapping to form unusual alkylmalonyl-CoA polyketide synthase extender units. Crotonyl-CoA can be used for the research of LPS-induced inflammatory response .

UCN-02 7-epi-Hydroxystaurosporine	Structural Classification Microorganisms Classification of Application Fields Antibiotics Antibacterial Disease Research Disease Research Fields Other Antibiotics Source Classification Cancer	PKC PKA
UCN-02 (7-epi-Hydroxystaurosporine) is a selective protein kinase C (PKC) inhibitor with a PKC IC₅₀ value of 62 nM and a PKA IC₅₀ value of 0.25 μM. UCN-02 can be produced by Streptomyces strain N-126. UCN-02 can be used for the research of breast carcinoma .

9-Hydroxyellipticine hydrochloride	Alkaloids Carbazole Alkaloids	Topoisomerase
9-Hydroxyellipticine hydrochloride is a inhibitor of Topo II and RyR. 9-Hydroxyellipticine hydrochloride exhibits antitumor, antioxidant and catecholamine-releasing activities. 9-Hydroxyellipticine hydrochloride exhibits IC₅₀ values of 1.6 μM and 1.2μM in Hela S-3 and 293T cells, respectively .

Eupaglehnin C	Terpenoids Sesquiterpenes Erythrina poeppigiana Plants Compositae Source Classification	Others
Eupaglehnin C is a germacrane-type sesquiterpenoi. Eupaglehnin C can be isolated from the MeOH extract of Eupatorium glehni (Compositae). Eupaglehnin C has cytotoxic activity against HeLa-S3 cancer cell lines .

Belactosin C	Natural Products Microorganisms Source Classification	Others
Belactosin C is found in the strain of Streptomyces sp. that inhibits HeLa S3 cells with the IC₅₀ of 200 μM .

Aplyronine C	Alkaloids Natural Products Classification of Application Fields Animals Disease Research Fields Cancer	Others
Aplyronine C is an active compound. Aplyronine C shows potent antitumor activity and has cytotoxicity against HeLa-S3 cells with an IC₅₀ values of 22 nM. Aplyronine C can be used for the research of cancer .

Aplyronine B	Alkaloids Natural Products Classification of Application Fields Animals Disease Research Fields Cancer	Others
Aplyronine B is an active compound. Aplyronine B shows potent antitumor activity and has cytotoxicity against HeLa-S3 cells with an IC₅₀ values of 2.9 nM. Aplyronine B can be used for the research of cancer .

Asperfuran	Infection Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Phenols Polyphenols Endogenous metabolite Disease Research Fields Source Classification	Fungal
Asperfuran is an antifungal dihydrobenzofuran derivative produced by a strain of Aspergillus oryzae. Asperfuran weakly inhibits chitin synthase from Coprinus cinereus. Asperfuran shows weak cytotoxicity In HeLa S3 and L1210 cells with an IC₅₀ of 25 μg/ml .

Cypemycin	Microorganisms Antibiotics Other Antibiotics Source Classification	Antibiotic Bacterial
Cypemycin is a linaridin antibiotic that can inhibit cancer cell activity, inhibits P388 leukemia cells with IC₅₀ of 1.3 μg/mL. Cypemycin can inhibit human tumor cells such as HeLa S3, HHCC-1, HCCS-M and Slex with IC₅₀ of >25 μg/mL .

9-Hydroxyellipticine hydrochloride (Standard)	Alkaloids Carbazole Alkaloids	Reference Standards Topoisomerase
9-Hydroxyellipticine (hydrochloride) (Standard) is the analytical standard of 9-Hydroxyellipticine (hydrochloride). This product is intended for research and analytical applications. 9-Hydroxyellipticine hydrochloride is a inhibitor of Topo II and RyR. 9-Hydroxyellipticine hydrochloride exhibits antitumor, antioxidant and catecholamine-releasing activities. 9-Hydroxyellipticine hydrochloride exhibits IC50 values of 1.6 μM and 1.2μM in Hela S-3 and 293T cells, respectively .

Belactosin A	Natural Products Microorganisms Source Classification	Others
Belactosin A is found in the strain of Streptomyces sp. that inhibits HeLa S3 cells with the IC₅₀ of 51 μM .

Furaquinocin A	Microorganisms Antibiotics Other Antibiotics Source Classification	Others
Furaquinocin A can kill HeLa S3 and B16 melanoma cells, but has no antibacterial activity .

Furaquinocin B	Microorganisms Antibiotics Other Antibiotics Source Classification	Others
Furaquinocin B can kill HeLa S3 and B16 melanoma cells, but has no antibacterial activity .

Furaquinocin C	Microorganisms Antibiotics Other Antibiotics Source Classification	Others
Furaquinocin CA can kill HeLa S3 and B16 melanoma cells, but has no antibacterial activity .

Clecarmycin C	Natural Products Microorganisms Source Classification	Antibiotic Bacterial
Clecarmycin C is an antitumor antibiotic. Clecarmycin C shows cytotoxicity and antitumor activity. Clecarmycin C shows antimicrobial activity .

Collinone	Microorganisms Antibiotics Other Antibiotics Source Classification	Antibiotic Bacterial
Collinone is a recombinant angular polyketide antibiotic. Collinone shows antibacterial activities for gram-positive bacterial. Collinone shows cytotoxicity .

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HeLa S3

Inhibitors & Agonists

Fluorescent Dyes

Biochemical Assay Reagents

Peptides

NaturalProducts

Natural
Products