51131-85-2
51131-85-2
Chemical Structure
9-Hydroxyellipticin
- CAS. Nr.: 51131-85-2
- Formula:C17H14N2O
- Molecular Weight:262.31
IUPAC Name: 5,11-dimethyl-6H-pyrido[4,3-b]carbazol-9-ol
InChIKey: QZTWUDDGLIDXSE-UHFFFAOYSA-N
SMILES: OC1=CC2=C(NC3=C2C(C)=C(C=NC=C4)C4=C3C)C=C1
Biological Activity: 9-hydroxyellipticine is an inhibitor of Topo II and RyR, exhibiting high affinity for DNA with a Pka value of 9.8 at pH 7.4. It has antitumor, antioxidant, and catecholamine-releasing activities, with IC50 values of 1.6 μM and 1.2 μM for Hela S-3 and 293T cells, respectively. It also demonstrates anticancer effects in L1210 leukemia mice[1].
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9-Hydroxyellipticin | 9-hydroxyellipticine is an inhibitor of Topo II and RyR, exhibiting high affinity for DNA with a Pka value of 9.8 at pH 7.4. It has antitumor, antioxidant, and catecholamine-releasing activities, with IC50 values of 1.6 μM and 1.2 μM for Hela S-3 and 293T cells, respectively. It also demonstrates anticancer effects in L1210 leukemia mice. | |||||||||||||||||||||
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