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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
26 Results for "
Human retinoblastoma
" in MedChemExpress (MCE) Product Catalog:
Products (26)
26 Results for "Human retinoblastoma" in MCE Product Catalog:
1
CDK2/4/6-IN-2 is a selective CDK2/4/6 inhibitor with IC50 values <1 μM. CDK2/4/6-IN-2 inhibits cells proliferation and phosphorylation of retinoblastoma protein at Ser807/811 in breast cancer cells. CDK2/4/6-IN-2 can be used for the research of cancer, such as breast cancer .
Cat. No.: HY-N0891
CAS No.: 115810-12-3
Synonyms: Tubeimoside-B
Cat. No.: HY-119715
CAS No.: 486414-35-1
Research Areas:
AG-012986 is a pan-CDK inhibitor with Ki values of 44 nM (CDK1), 9.2 nM (CDK4), 94 nM (CDK2), and IC50 values of 22 nM (CDK5), 4 nM (CDK9). AG-012986 causes apoptosis of T-cells by targeting upstream kinases in the p38 Mitogen-activated protein kinase (MAPK) pathway and impairing cellular survival. AG-012986 induces cell cycle arrest, retinoblastoma protein hypophosphorylation, and reduces Ki-67 expression. AG-012986 exerts antiproliferative activity in tumor cells, demonstrates antitumor efficacy in human xenograft models, and causes retinal and peripheral neurotoxicity, plus immune cell toxicity. AG-012986 can be used for the research of colon carcinoma, non-small cell lung carcinoma, lung carcinoma, breast carcinoma, ovarian tumor, pancreatic carcinoma, osteosarcoma, lymphoma, leukemia, retinotoxicity .
Target:
Cat. No.: HY-131605B
Synonyms: GCV-TP disodium
Target:
Ganciclovir triphosphate disodium solution (100 mM ± 3 mM) (GCV-TP disodium) is a competitive DNA polymerase inhibitor and a metabolite of Ganciclovir (HY-13637). Ganciclovir triphosphate disodium solution (100 mM ± 3 mM) can replace Guanine-5'-triphosphate to terminate DNA chain extension, and mimics dGTP (HY-138616) to compete with mammalian DNA polymerases. Ganciclovir triphosphate disodium solution (100 mM ± 3 mM) can be used in research related to HSV infection, retinoblastoma, glioblastoma and colorectal cancer .
Cat. No.: HY-131605
CAS No.: 86761-38-8
Synonyms: GCV-TP
Target:
Research Areas:
Ganciclovir triphosphate (GCV-TP) is a competitive DNA polymerase inhibitor and a metabolite of Ganciclovir (HY-13637). Ganciclovir triphosphate can replace Guanine-5'-triphosphate to terminate DNA chain extension, and mimics dGTP (HY-138616) to compete with mammalian DNA polymerases. Ganciclovir triphosphate can be used in research related to HSV infection, retinoblastoma, glioblastoma and colorectal cancer .
Cat. No.: HY-128020
CAS No.: 866149-26-0
Target:
Research Areas:
ML114 is a specific inhibitor of RBBP9 serine hydrolase, with an IC50 of 0.63 μM against recombinant RBBP9. ML114 can inhibit the proliferation of human pluripotent stem cells (hPSCs) by regulating the expression of NFYA and other factors, but does not induce differentiation. ML114 can be used in the research of diseases such as retinoblastoma .
Cat. No.: HY-E70678
CDK3 is a major player driving retinoblastoma (Rb) phosphorylation during the G0/G1 transition and in the early G1 phase of the cell cycle. CDK3 interacts with various transcription factors involved in cell proliferation, differentiation, and transformation driven by the EGFR/Ras signaling pathway. CDK3/CycE1 Recombinant Human Active Protein Kinase is an ortholog of CDK3 .
Cat. No.: HY-N0891R
CAS No.: 115810-12-3
Synonyms: Tubeimoside-B (Standard)
Category:
Cat. No.: HY-14132
CAS No.: 1173435-64-7
Target:
Research Areas:
BMS-665053 is a corticotropin-releasing factor-1 (CRF1) receptor antagonist (IC50 = 1.0 nM). BMS-665053)11 is a potent inhibitor of CRF-stimulated cyclic adenosine monophosphate (cAMP) production in human Y-79 retinoblastoma cells (IC50 = 4.9 nM) .
Cat. No.: HY-E70677
CDK3 is a major player driving retinoblastoma (Rb) phosphorylation during the G0/G1 transition and in the early G1 phase of the cell cycle. CDK3 interacts with various transcription factors involved in cell proliferation, differentiation, and transformation driven by the EGFR/Ras signaling pathway. CDK3/CycC Recombinant Human Active Protein Kinase is an ortholog of CDK3 .
Cat. No.: HY-E70680
CDK3 is a major player driving retinoblastoma (Rb) phosphorylation during the G0/G1 transition and in the early G1 phase of the cell cycle. CDK3 interacts with various transcription factors involved in cell proliferation, differentiation, and transformation driven by the EGFR/Ras signaling pathway. CDK3/CycO Recombinant Human Active Protein Kinase is an ortholog of CDK3 .
Cat. No.: HY-P703588
Purity: ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: RB1; P110-RB1; Prev. OSRC; Pp110; retinoblastoma-Associated Protein; Mutant retinoblastoma-Associated Protein; retinoblastoma 1; retinoblastoma Susceptibility Protein; PPP1R130; Mutated retinoblastoma Protein; PRb; retinoblastoma; RB; Osteosarcoma; Protei
Species:
Human
Source:
E. coli
Cat. No.: HY-P85617
Synonyms: RBBP 5; RBBP-5; RBBP5; RBBP5_Human; RBQ 3; RBQ3; retinoblastoma binding protein 5; retinoblastoma binding protein RBQ3; retinoblastoma binding protein5; retinoblastoma-binding protein 5; retinoblastoma-binding protein RBQ-3; SWD1; SWD1, Set1c WD40 repeat protein, homolog.
Cat. No.: HY-E70679
CDK3 is a major player driving retinoblastoma (Rb) phosphorylation during the G0/G1 transition and in the early G1 phase of the cell cycle. CDK3 interacts with various transcription factors involved in cell proliferation, differentiation, and transformation driven by the EGFR/Ras signaling pathway. CDK3/CycE2 Recombinant Human Active Protein Kinase is an ortholog of CDK3 .
Cat. No.: HY-P701105
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: PRDM2; retinoblastoma Protein-Binding Zinc Finger Protein; PR/SET Domain 2; PR Domain Containing 2, With ZNF Domain; MTB-ZF; Zinc-Finger DNA-Binding Protein; KMT8; PR Domain Zinc Finger Protein 2; RIZ; PR Domain-Containing Protein 2; retinoblastoma Protei
Species:
Human
Source:
E. coli
Cat. No.: HY-P76579
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: PRDM2; retinoblastoma Protein-Binding Zinc Finger Protein; PR/SET Domain 2; PR Domain Containing 2, With ZNF Domain; MTB-ZF; Zinc-Finger DNA-Binding Protein; KMT8; PR Domain Zinc Finger Protein 2; RIZ; PR Domain-Containing Protein 2; retinoblastoma Protei
Species:
Human
Source:
E. coli
Cat. No.: HY-P76580
Purity: ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: PRDM2; retinoblastoma Protein-Binding Zinc Finger Protein; PR/SET Domain 2; PR Domain Containing 2, With ZNF Domain; MTB-ZF; Zinc-Finger DNA-Binding Protein; KMT8; PR Domain Zinc Finger Protein 2; RIZ; PR Domain-Containing Protein 2; retinoblastoma Protei
Species:
Human
Source:
E. coli
Cat. No.: HY-186132
CAS No.: 3030276-48-0
PROTAC CDK2-pRb degrader-1 is an orally active PROTAC-class degrader of CDK2. PROTAC CDK2-pRb degrader-1 effectively inhibits the phosphorylation of retinoblastoma protein (Rb) at serine residues 807/811 by inducing ubiquitination and proteasomal degradation of CDK2. PROTAC CDK2-pRb degrader-1 exhibits significant activity against human cells (with EC50 values of 12 nM and 125 nM, respectively). In xenograft models, PROTAC CDK2-pRb degrader-1 effectively inhibits tumor growth and induces tumor stasis, making it suitable for research related to CCNE1-amplified cancers (such as ovarian cancer, gastric cancer, and breast cancer) .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
