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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
111 Results for "
ILT
" in MedChemExpress (MCE) Product Catalog:
Products (111)
111 Results for "ILT" in MCE Product Catalog:
5
Cat. No.: HY-P99226
CAS No.: 2245966-28-1
Synonyms: MEDI7734; VIB7734
Research Areas:
Daxdilimab (MEDI7734; VIB7734) is a monoclonal antibody targeting immunoglobulin-like transcript 7 (ILT7) that depletes plasmacytoid dendritic cells and reduces IFN1 production by binding to the plasmacytoid dendritic cell-specific surface molecule ILT7 and recruiting effector natural killer cells. Daxdilimab (MEDI7734; VIB7734) can be used for research on systemic lupus erythematosus, systemic sclerosis, and polymyositis .
Cat. No.: HY-P990462
Target:
Research Areas:
Cat. No.: HY-P991230
MK-4830 is a fully humanized monoclonal antibody of the immunoglobulin G4 subclass that specifically binds to ILT4 and blocks its interaction with HLA-G and other ligands. MK-4830 inhibits tumor growth in humanized mouse cancer models .
Cat. No.: HY-P991307
Target:
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Cat. No.: HY-P991093
Target:
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Cat. No.: HY-P991306
Target:
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Cat. No.: HY-P990061
CAS No.: 2640981-19-5
Synonyms: JTX-8064
Target:
Research Areas:
Polzastobart (JTX-8064) is a humanized IgG4 monoclonal antibody and LILRB2 (ILT4) antagonist. Polzastobart specifically binds to and antagonizes LILRB2, relieves ILT4-mediated myeloid immunosuppression, and promotes the polarization of macrophages from an M2-like phenotype to an M1-like phenotype. Polzastobart induces macrophage polarization, IFNγ signaling, and T cell inflammation-related pharmacodynamic responses in ex vivo human renal cancer, lung cancer, and head and neck cancer tissues. Polzastobart can be used in studies related to tumor-associated macrophages and tumor immunity. For the isotype control of Polzastobart, refer to: Human IgG4 (S228P) kappa, Isotype Control (HY-P99003) .
Cat. No.: HY-P991308
Target:
Cat. No.: HY-P991305
Target:
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Cat. No.: HY-P991606
Research Areas:
Cat. No.: HY-P70168
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: LILRB2; Monocyte/Macrophage Immunoglobulin-Like Receptor 10; Leukocyte Immunoglobulin Like Receptor B2; CD85 Antigen-Like Family Member D; MIR-10; Myeloid Inhibitory Receptor 10; LIR-2; Leucocyte Ig-Like Receptor B2; MIR10; ILT-4; ILT4; Leukocyte Immunogl
Species:
Human
Source:
HEK293
Cat. No.: HY-P704761
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: LILRB2; Monocyte/Macrophage Immunoglobulin-Like Receptor 10; Leukocyte Immunoglobulin Like Receptor B2; CD85 Antigen-Like Family Member D; MIR-10; Myeloid Inhibitory Receptor 10; LIR-2; Leucocyte Ig-Like Receptor B2; MIR10; ILT-4; ILT4; Leukocyte Immunoglobulin-Like Receptor 2; LIR2; Immunoglobulin-Like Transcript 4; Leukocyte Immunoglobulin-Like Receptor Subfamily B Member 2; Ig-Like Transcript 4; CD85d; CD85d Antigen; Leukocyte Immunoglobulin-Like Receptor, Subfamily B (With TM And ITIM Domains), Member 2
Species:
Human
Source:
HEK293
Cat. No.: HY-P992260
Target:
Research Areas:
Cat. No.: HY-189068
CAS No.: 1240895-94-6
GL-4512 is an orally active LILRB4/ILT3 inhibitor with an IC50 of 37 nM against human targets, and human Kd values of 18.1 nM and 39.2 nM, respectively. GL-4512 directly binds to the extracellular pockets of LILRB4/ILT3 that accommodate their ligands, blocks the LILRB4-SCG2 signaling pathway, and inhibits the downstream SHP1/SHP2 and STAT3 signaling pathways. GL-4512 restores anti-tumor immune activity, promotes the production of IFN-γ and IL-2, enhances the activation of cytotoxic T cells, reduces tumor cell viability, inhibits tumor growth, and strengthens intratumoral immune activation. GL-4512 can be used in research related to colorectal cancer and acute myeloid leukemia .
Cat. No.: HY-189933
CAS No.: 920836-30-2
Target:
Human leukocyte immunoglobulin (Ig)-like receptors (LILR) SHP1 SHP2 STAT IFNAR Interleukin Related
Research Areas:
ICB-7 is an orally active ILT3/LILRB4 inhibitor with a Kd of 156 nM for hILT3 and a Kd of 262 nM for mouse ILT3. ICB-7 reduces SCG2-induced phosphorylation of SHP1, SHP2, and STAT3. In a co-culture model, ICB-7 restores IFN-γ and IL-2 secretion and decreases cell viability under SCG2 stimulation. In a syngeneic cancer model, ICB-7 inhibits tumor progression and reduces final tumor weight. ICB-7 can be used for research on colorectal cancer and acute myeloid leukemia .
Cat. No.: HY-P704692
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: IL15; Interleukin-15; Interleukin 15; MGC9721; IL-15
Species:
Human
Source:
HEK293
Cat. No.: HY-P704691
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: IL15; Interleukin-15; Interleukin 15; MGC9721; IL-15
Species:
Human
Source:
HEK293
Cat. No.: HY-P704693
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: IL15; Interleukin-15; Interleukin 15; MGC9721; IL-15
Species:
Human
Source:
HEK293
Cat. No.: HY-P705124
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: IL15; Interleukin-15; Interleukin 15; MGC9721; IL-15
Species:
Human
Source:
HEK293
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
