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Isoforms Recommended:	Metallo-β-lactamase (MBL)

Results for "

IMP-1

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Bacterial (11) Beta-lactamase (14) Dopamine Transporter (1) Monoamine Transporter (1) Serotonin Transporter (1) Small Interfering RNA (siRNA) (5)
By Research Areas:	Infection (15) Neurological Disease (1)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (3) siRNAs (5)

Inhibitors & Agonists

Recombinant Proteins

Antibodies

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-148493

MK-3402	Bacterial	Infection
MK-3402 (Compound303) is a metallo-beta-lactamase inhibitor, with IC₅₀ values of 0.53, 0.25 and 0.169 nM against *IMP-1, NDM-1, and VIM-1*, respectively. MK-3402 can be used in bacterial research and shows a synergistic effect when used in combination with beta-lactam antibiotics ^[1].

HY-RS06619

IGF2BP1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
IGF2BP1 Human Pre-designed siRNA Set A contains three designed siRNAs for IGF2BP1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

IGF2BP1 Human Pre-designed siRNA Set A IGF2BP1 Human Pre-designed siRNA Set A

HY-W703376

2-(tert-Butylamino)-1-phenylpropan-1-one hydrochloride	Serotonin Transporter Monoamine Transporter Dopamine Transporter	Neurological Disease
2-(tert-Butylamino)-1-phenylpropan-1-one hydrochloride (Compound Imp.1) is a non-selective monoamine transporter (DAT/NET/SERT) agonist. tert-Butylcathinone hydrochloride is promising for research of depressive disorders ^[1].

HY-178976

YL6113	Beta-lactamase	Infection
YL6113 is a potent and selective dual inhibitor of metallo-β-lactamases (MBLs) and serine-β-lactamases (SBLs). YL6113 shows inhibitory effect to MBLs, such as NDm-1, VIM-2, IMP-1, with IC₅₀ values of 0.25, 27.16 and 3.55 μM. YL6113 shows inhibitory effect to SBLs, such as KPC-2, AmpC, OXA-48, with IC₅₀ values of 0.2, 34.1 and 1.31 μM. YL6113 enhances the antibacterial efficacy of Meropenem (HY-13678) against carbapenem-resistant Gram-negative bacteria. YL6113 can be used for the research of infection ^[1].

HY-175488

RPX 7546	Beta-lactamase Bacterial	Infection
RPX 7546 is a potent inhibitor of metallo-𝛽-lactamases (MBLs) with IC₅₀ values of 1.4 and 48 μM for IMP-1 and IMP-78, respectively. RPX 7546 has antibacterial activity ^[1].

HY-176519

ANT2681	Beta-lactamase Bacterial	Infection
ANT2681 is a potent NDM inhibitor with a K_i value of 0.04 μM against *NDM-1. ANT2681 also inhibits other MBLs, such as VIM-1* and *IMP-1* with K_i values of 0.63 μM and 3.81 μM, respectively. ANT2681 can be used in combination with Meropenem (HY-13678) to inhibit infections caused by NDM-producing Enterobacteriaceae ^[1].

HY-152105

Metallo-β-lactamase-IN-9	Beta-lactamase Bacterial	Infection
Metallo-β-lactamase-IN-9 (Compound 23) is a pan metallo-beta-lactamase (MBL) inhibitor with IC₅₀s of 35, 269 and 369 nM against *NDM-1, VIM-1* and *IMP-1*, respectively ^[1].

HY-146165

Metallo-β-lactamase-IN-8	Beta-lactamase Bacterial	Infection
Metallo-β-lactamase-IN-8 (compound 17) is a potent, reversible and competitive broad-spectrum inhibitor of metallo-β-lactamases (MβLs), with IC₅₀s of 1.3 μM, 5.7 μM, 9.8 μM, and 9.9 μM for L1, ImiS, *IMP-1* and VIM-2, respectively. Metallo-β-lactamase-IN-8 exhibits antibacterial activity ^[1].

HY-168500

Metallo-β-lactamase-IN-16	Beta-lactamase Bacterial	Infection
Metallo-β-lactamase-IN-16 (compound 18) is a sulfone containing metallo-β-lactamase inhibitor with an anti-bacterial activity. Metallo-β-lactamase-IN-16 inhibits NDM-1 (New Dehli metallo-β-lactamase-1), IMP-1 (imipenemase-1), VIM-1 (Verona integron-encoded metallo-β-lactamase), and VIM-2 with IC₅₀ values of 0.16 nM, 0.23 nM, 0.31 nM and 1.0 nM, respectively ^[1].

HY-158375

MBL-IN-4	Beta-lactamase Bacterial	Infection
MBL-IN-4 (compound 4b) is a MBL inhibitor with the IC₅₀ of 4.81 and 33 μM against IMP-1 and NDM-1 ^[1].

HY-175489

D-CS319	Beta-lactamase Bacterial	Infection
D-CS319 is a potent inhibitor of metallo-𝛽-lactamases (MBLs) with IC₅₀ values of 2.0 and 3.0 μM for IMP-1 and IMP-78, respectively. D-CS319 has antibacterial activity ^[1].

HY-128049

ML121	Beta-lactamase	Infection
ML121 is a selective and potent VIM-2 inhibitor with an IC₅₀ of 54 nM and a K_i of 148 nM. ML121 shows inactive in IMP-1 and TEM-1 beta-lactamase assays. ML121 can potentiate the antibiotic activity of Imipenem (HY-B1369A) in VIM-2 transformed E.coli ^[1].

HY-155201

YJ182	Bacterial	Infection
YJ182 is a *NDM-1* inhibitor (IC₅₀: 0.23 μM). YJ182 also inhibits IMP-1, VIM-2, GIM-1, and MMP-2, with IC₅₀s of 0.25, 0.61, 0.49, and 6.92 μM respectively. YJ182 can be used for bacterial infection research ^[1].

HY-161094

Metallo-β-lactamase-IN-12	Beta-lactamase Bacterial	Infection
Metallo-β-lactamase-IN-12 is a dual inhibitor of metal β-lactamases (MβLs (NDM-1, IMP-1)) and serine β-lactamases (SβLs (OXA-48, KPC-2)), with IC₅₀ values of 0.64 μM, 1.32 μM, 1.01 μM, and 0.57 μM, respectively. Metallo-β-lactamase-IN-12 has antibacterial activity ^[1].

HY-B0368C

epi-D-Captopril epi-D-SQ 14225	Beta-lactamase	Infection
epi-D-Captopril (epi-D-SQ 14225) is a stereoisomer of Captopril (HY-B0368) and an inhibitor of metallo-β-lactamases (MBLs). The IC₅₀ values of epi-D-Captopril against *NDM-1, IMP-1, and VIM-2* are 64 μM, 173 μM, and 5.5 μM, respectively. epi-D-Captopril is expected to be used in the research of diseases caused by MBLs-related drug-resistant bacterial infections ^[1].

HY-173472

MBL-IN-5	Bacterial Beta-lactamase	Infection
MBL-IN-5 is a metallo-β-lactamase (MBL) inhibitor. MBL-IN-5 inhibits three clinically relevant B1 subfamily MBLs (NDM-1, VIM-1, and IMP-1) with IC₅₀s of 0.05  nM, 14  nM and 21 nM respectively. MBL-IN-5 remarkably enhances carbapenems’ effectiveness against MBL-producing clinical strains and significantly reduces the bacterial load in a neutropenic murine thigh infection model combined with the IPM antibiotic ^[1].

HY-RS23290

Igf2bp1 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Igf2bp1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Igf2bp1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Igf2bp1 Rat Pre-designed siRNA Set A Igf2bp1 Rat Pre-designed siRNA Set A

HY-RS16432

IMMP1L Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
IMMP1L Human Pre-designed siRNA Set A contains three designed siRNAs for IMMP1L gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

IMMP1L Human Pre-designed siRNA Set A IMMP1L Human Pre-designed siRNA Set A

HY-161310

Metallo-β-lactamase-IN-15	Beta-lactamase	Infection
Metallo-β-lactamase-IN-15 (Compound ±13) is a potent MBL inhibitor, the IC₅₀ values for NDM-1、IMP-1 and VIM-2 were 0.29 μM, 0.088 μM and 0.063 μM, respectively ^[1].

HY-RS06222

HM13 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
HM13 Human Pre-designed siRNA Set A contains three designed siRNAs for HM13 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HM13 Human Pre-designed siRNA Set A HM13 Human Pre-designed siRNA Set A

HY-W002684

(S)-2-Benzylsuccinic acid	Beta-lactamase	Others
(S)-2-Benzylsuccinic acid is an intermediate of KAD-1229 (HY-B0682A). (S)-2-Benzylsuccinic acid exerts weak inhibitory activity against IMP-1 metallo-β-lactamase ^[1].

HY-RS16849

Igf2bp1 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Igf2bp1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Igf2bp1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Igf2bp1 Mouse Pre-designed siRNA Set A Igf2bp1 Mouse Pre-designed siRNA Set A

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P70335

	IMPA1 Protein, Human (His) rHuInositol monophosphatase 1/IMPA1, His; Inositol Monophosphatase 1; IMP 1; IMPase 1; Inositol-1(or 4)-Monophosphatase 1; Lithium-Sensitive Myo-Inositol Monophosphatase A1; IMPA1; IMPA	Human	E. coli
	IMPA1 protein provides essential inositol for the synthesis of phosphatidylinositol and polyphosphate inositol. IMPA1 Protein, Human (His) is the recombinant human-derived IMPA1 protein, expressed by E. coli , with N-6*His labeled tag.

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Host:	Rabbit (2)
Reactivity:	Human (2) Mouse (2)
Application:	IHC-P (2) IP (2) WB (2)
Isotype:	IgG (2)
Conjugation:	Non-conjugated (2)
Clonality:	Monoclonal (1) Recombinant (1)
Modification:	Unmodified (1)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P83326

	IGF2BP1 Antibody (YA3071) insulin-like growth factor 2 mRNA binding protein 1; IMP1; ZBP1; CRDBP; IMP-1; CRD-BP; VICKZ1	WB, IHC-P, IP	Human, Mouse
	IGF2BP1 Antibody (YA3071) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to IGF2BP1.

HY-P83326A

	IGF2BP1 Antibody (YA3071)(PBS only) insulin-like growth factor 2 mRNA binding protein 1; IMP1; ZBP1; CRDBP; IMP-1; CRD-BP; VICKZ1	WB, IHC-P, IP	Human, Mouse
	IGF2BP1 Antibody (YA3071) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to IGF2BP1.