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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
4 Results for "
IRF5 degrader
" in MedChemExpress (MCE) Product Catalog:
Products (4)
4 Results for "IRF5 degrader" in MCE Product Catalog:
Cat. No.: HY-175759
CAS No.: 2193367-28-9
Target:
Research Areas:
EN1033 is a covalent immune regulatory transcription factor 5/8 (IRF5/8) molecular glue degrader. EN1033 degrades IRF5 in a proteasome-dependent manner. EN1033 engages and degrades IRF8 more robustly and rapidly. EN1033 covalently targets C28 and C223 to destabilize and degrade IRF5 and IRF8 respectively, thereby inhibiting their pro-inflammatory transcriptional activity. EN1033 serves as a promising tool for the study of autoimmune and inflammatory disorders .
Cat. No.: HY-186312
Research Areas:
PROTAC IRF5 degrader-2 (I-7) is a bifunctional IRF5 PROTAC degrader. PROTAC IRF5 degrader-2 recruits IRF5 to the E3 ubiquitin ligase for targeted degradation. PROTAC IRF5 degrader-2 is applicable to the research of autoimmune diseases .
Cat. No.: HY-186304
Target:
Research Areas:
PROTAC IRF5 degrader-1 (I-867) is a CRBN-recruiting PROTAC degrader targeting IRF5. PROTAC IRF5 degrader-1 recruits interferon regulatory factor 5 (IRF5) protein to the E3 ubiquitin ligase for degradation. PROTAC IRF5 degrader-1 can be used in the research of autoimmune diseases .
Cat. No.: HY-188209
CAS No.: 3137885-65-2
Research Areas:
PROTAC IRF5 degrader-3 is a PROTAC degrader targeting interferon regulatory factor 5 (IRF5), with a DC50 of 1-10 nM. PROTAC IRF5 degrader-3 can be used in research on IRF5-associated autoimmune and inflammatory diseases, such as systemic lupus erythematosus and rheumatoid arthritis .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
