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Cat. No.: HY-186304

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PROTAC IRF5 degrader-1

PROTAC IRF5 degrader-1 is a IRF5 PROTAC degrader that recruits CRBN. PROTAC IRF5 degrader-1 recruits IRF5 to the E3 ubiquitin ligase to achieve degradation. PROTAC IRF5 degrader-1 can be used for research on autoimmune diseases.

For research use only. We do not sell to patients.

Formula: C₄₈H₅₆F₃N₉O₄
Molecular Weight:880.01

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (280 KB)

PROTAC IRF5 degrader-1 Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

All PROTACs Isoforms :

In Vitro

PROTAC IRF5 degrader-1 (I-867) degrades IRF5 in the HiBiT degradation assay in THP1‑IRF5‑HiBiT‑B8 cells, with DC₅₀ < 1 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Molecular Weight 880.01
Formula C₄₈H₅₆F₃N₉O₄
SMILES

CC1N=C(C2=CC=C(CN21)[C@H]3CCN(C[C@@H]3F)[C@H]4CC[C@@H](CC4)CC5=CC(C6=CN(C=N6)CC7CCC(F)(CC7)F)=NC(OC8=C9NC(N(C9=CC=C8)C)=O)=C5)C%10CCC(NC%10=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (280 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Zhang, Y, et al. IRF5 degraders and uses thereof. WO2026156070. WIPO. 23.07.2026.

Calculators

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Dilution Calculator

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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