Search Result
Results for "
Iridoid Glycosides
" in MedChemExpress (MCE) Product Catalog:
| Cat. No. |
Product Name |
Target |
Research Areas |
Chemical Structure |
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- HY-N0820
-
Catalpol
Maximum Cited Publications
13 Publications Verification
Catalpinoside
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HBV
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Infection
Neurological Disease
Inflammation/Immunology
Cancer
|
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Catalpol (Catalpinoside), an iridoid glycoside found in Rehmannia glutinosa. Catalpol has neuroprotective, hypoglycemic, anti-inflammatory, anti-cancer, anti-spasmodic, anti-oxidant effects and anti-HBV effects .
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-
-
- HY-N0664
-
|
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Bacterial
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Infection
Neurological Disease
Metabolic Disease
Inflammation/Immunology
Cancer
|
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Aucubin is an iridoid glycoside component that acn be found in E. ulmoides. Aucubin can cross the blood-brain barrier (BBB) and has anti-anxiety, antidepressive and anti-neuroinflammatory effects. Aucubin has many biological activities, such as antioxidant, anti-aging, anti-inflammatory, antimicrobial, anti-fibrotic, anti-cancer, hepatoprotective, neuroprotective and osteoprotective effects .
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-
-
- HY-N0494
-
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Gentiopicrin
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Cytochrome P450
HCV
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Inflammation/Immunology
|
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Gentiopicroside, a naturally occurring iridoid glycoside, inhibits P450 activity, with an IC50 and a Ki of 61 μM and 22.8 μM for CYP2A6; Gentiopicroside has anti-inflammatoryand antioxidative effects.
|
-
-
- HY-N0512
-
Loganin
5 Publications Verification
Loganoside
|
Reactive Oxygen Species (ROS)
TNF Receptor
Interleukin Related
|
Neurological Disease
Inflammation/Immunology
Cancer
|
|
Loganin is a type of iridoid glycoside compound that possesses anti-inflammatory, antioxidant, and antitumor properties, and offers protective effects against acute lung injury and pulmonary fibrosis. Loganin exerts its protective effects against LPS (HY-D1056)-mediated inflammation and oxidative stress by upregulating the Nrf2/HO-1 signaling pathway, and it reduces neuroinflammation caused by spinal cord injury (SCI) .
|
-
-
- HY-N6246
-
|
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NF-κB
ERK
|
Inflammation/Immunology
Cancer
|
|
Asperulosidic Acid (ASPA), a bioactive iridoid glycoside, is extracted from the herbs of Hedyotis diffusa Willd. Asperulosidic Acid (ASPA) has anti-tumor, anti-oxidant, and anti-inflammatory activities .
ASPA is related to the inhibition of inflammatory cytokines (TNF-α, IL-6) and mediators via suppression of the NF-κB and mitogen-activated protein kinase (MAPK) signaling pathways .
|
-
-
- HY-N0806
-
|
|
Keap1-Nrf2
AMPK
Sirtuin
NF-κB
NOD-like Receptor (NLR)
Pyroptosis
Apoptosis
Autophagy
PARP
|
Cardiovascular Disease
Metabolic Disease
Inflammation/Immunology
Cancer
|
|
Sweroside is an iridoid glycoside that targets multiple targets, including the Keap1/Nrf2 axis, NLRP3 inflammasome, SIRT1, NF-κB, AMPK/mTOR pathway, and caspase family. Sweroside promotes Nrf2 nuclear translocation by competitively binding to Keap1. Sweroside also inhibits oxidative stress and NLRP3-mediated pyroptosis by activating Nrf2, inhibits NF-κB inflammatory pathway by activating SIRT1, and promotes autophagy and induces caspase-dependent apoptosis via the AMPK/mTOR pathway. Sweroside has antioxidant, anti-inflammatory, anti-apoptotic, and lipid metabolism regulating activities, and can be used in the research of myocardial ischemia-reperfusion injury, leukemia, acute lung injury, non-alcoholic fatty liver disease, and other fields .
|
-
-
- HY-N0631
-
|
|
p38 MAPK
NF-κB
JNK
Cholinesterase (ChE)
Acyltransferase
NO Synthase
Interleukin Related
TNF Receptor
Prostaglandin Receptor
ERK
COX
|
Neurological Disease
Inflammation/Immunology
|
|
Cornuside is an iridoid glycoside with anti-allergic, anti-inflammatory, and neuroprotective activities. Cornuside exerts anti-allergic activity by downregulating the p38 MAPK, JNK, and NF-κB signaling pathways, and inhibits IgE-mediated histamine release from mast cells. Cornuside improves cognitive impairment in mice by inhibiting BACE1 activity (IC50 = 55.84 μg/mL) and enhancing ChAT activity. Cornuside inhibits LPS (HY-D1056)-induced inflammatory mediators, including iNOS, COX-2, PGE2, TNF-α, IL-6, and IL-1β, by suppressing NF-κB activation .
|
-
-
- HY-N0914
-
-
-
- HY-N0648
-
|
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Interleukin Related
Keap1-Nrf2
Heme Oxygenase (HO)
NF-κB
Apoptosis
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Inflammation/Immunology
|
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Monotropein is an iridoid glycoside that can be isolated from the roots of Morinda officinalis. Monotropein inhibits the expression of inflammatory mediators in dextran sulfate sodium (DSS)-induced colitis mouse model. Monotropein exerts protective effects against IL-1β-induced apoptosis and catabolic responses on osteoarthritis chondrocytes. Monotropein has cartilage protective activity. Monotropein can alleviate Cisplatin (HY-17394)-induced acute kidney injury by inhibiting oxidative damage, inflammation and apoptosis through activation of Nrf2/HO-1 pathway and inhibition of NF-κB signaling. Monotropein can be studied in research for osteoarthritis, acute kidney injury and acute lung injury .
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- HY-N0757
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Akt
Bcl-2 Family
Apoptosis
Adrenergic Receptor
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Cardiovascular Disease
Inflammation/Immunology
Cancer
|
|
8-O-Acetylharpagide is an orally active iridoid glycoside compound. 8-O-Acetylharpagide exhibits anti-aging activity at low doses and anticancer activity at high doses. 8-O-Acetylharpagide induces late-stage apoptosis and necrosis-like death in cancer cells, and downregulates anti-apoptotic proteins such as Akt, p-Akt and Bcl-2. 8-O-Acetylharpagide is mainly metabolized in rats via demethylation, hydrolysis and glucuronidation, and its active metabolites downregulate the AKT/NF-κB/MMP9 signaling axis. 8-O-Acetylharpagide exerts vasoconstrictive effects by activating vascular α-adrenoceptor .
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- HY-N2015
-
|
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Others
|
Neurological Disease
|
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Hastatoside is an iridoid glycoside that is isolated from Verbena officinalis and has a role in promoting sleep .
|
-
-
- HY-N0397
-
|
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Parasite
|
Infection
Inflammation/Immunology
|
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Harpagide is a class of iridoid glycoside isolated from Scrophularia ningpoensis and has antiparasitic activity, which exhibits good in vitro trypanocidal activities against African trypanosomes (T.b. rhodesiense) with an IC50 of 21 μg/mL. Harpagide exerts significant antileishmanial activity against L. donovani with an IC50 value of 2.0 μg/mL. Harpagide also possess significant anti-inflammatory activities .
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-
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- HY-N2094
-
|
Genipin 1-gentiobioside; Genipin 1-β-gentiobioside; Genipin gentiobioside
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Others
|
Inflammation/Immunology
|
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Genipin 1-β-D-gentiobioside (Genipin 1-gentiobioside) is one of the most abundant and bioactive iridoid glycosides in Gardenia jasminoides Ellis, which possesses hepatoprotective, anti-inflammatory, antioxidant, and antithrombotic activities.
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- HY-N5070
-
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Depressin
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Biochemical Assay Reagents
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Others
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Depressine is an iridoid glycoside that can be isolated from the methanol extract of the aerial parts of Gentiana depressa. Depressine can be used to reduce oxidative DNA base damage and strand breaks that are prone to occur during the preparation of silver nanoparticles (AgNPs) .
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- HY-N5086
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-
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- HY-N0409
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|
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Others
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Inflammation/Immunology
|
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Picroside III is an iridoid glycoside isolated from Picrorhiza scrophulariiflora (PS), a traditional Chinese medicine .
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-
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- HY-N8046
-
|
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Others
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Others
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Gardoside is an iridoid glycoside that can be found in the roots of L. alba .
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- HY-N9352
-
|
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Others
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Others
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Cantleyoside is a natiural iridoid glycoside that could be found in the Roots of Dipsacus asper .
|
-
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- HY-N0820R
-
|
Catalpinoside (Standard)
|
Reference Standards
HBV
|
Infection
Neurological Disease
Inflammation/Immunology
Cancer
|
|
Catalpol (Standard) is the analytical standard of Catalpol. This product is intended for research and analytical applications. Catalpol (Catalpinoside), an iridoid glycoside found in Rehmannia glutinosa. Catalpol has neuroprotective, hypoglycemic, anti-inflammatory, anti-cancer, anti-spasmodic, anti-oxidant effects and anti-HBV effects .
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- HY-N0916
-
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Danmelittoside
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Bacterial
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Inflammation/Immunology
|
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Monomelittoside is a iridoid glycoside with antibacterial activity. Monomelittoside inhibits dental caries pathogen Streptococcus.
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-
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- HY-N12840
-
-
-
- HY-N6008
-
|
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Others
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Others
|
|
7-O-Methyl morroniside is an iridoid glycoside (IG) extracted from Cornus officinalis fructus, used in many traditional Chinese medicines .
|
-
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- HY-N2712
-
|
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Others
|
Others
|
|
6''-O-trans-Feruloylcatalpol is a natural iridoid glycoside compound .
|
-
-
- HY-N1206
-
|
6-O-(E)-p-Coumaroylcatalpol
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Others
|
Others
|
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Specioside is a novel iridoid glycoside extracted from Catalpa speciosa Warder (Bignoniaceae) .
|
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-
- HY-121125
-
|
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Others
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Others
|
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Aucubigenin, the aglycone of the iridoid glycoside aucubin, has been characterized through X-ray diffraction analysis. Its crystal structure reveals monoclinic symmetry with specific conformations adopted by its cyclopentane and pyran rings. The study also determined the absolute configurations of both aucubin and aucubigenin. Significant O-H O hydrogen bonding interactions were observed in the crystal lattices of both compounds, highlighting their structural stability and potential for intermolecular interactions .
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- HY-133109
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Others
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Others
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Trachelosiaside is a natural organic compound belonging to the class of iridoid glycosides. Trachelosiaside is found in various plant species, especially in the roots of Trachelospermum jasminoides. Trachelosiaside has potential medicinal properties, such as anti-inflammatory, antioxidant, and anti-tumor effects. Trachelosiaside has industrial applications in the production of food supplements, cosmetics and pharmaceuticals.
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- HY-N0914R
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-
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- HY-N13109
-
|
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Others
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Others
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Caprarioside is an iridoid glycoside that can be isolated from Capraria biflora L. .
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-
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- HY-N11794
-
|
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Others
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Others
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7-Ketologanin is an iridoid glucoside. 7-Ketologanin can be isolated from the Stems of Viburnum erosum. 7-Ketologanin involves in biosynthetic pathway of oleuropein. Oleuropein, is a bioactive phenolic compound, modulates several oncogenic signalling pathways .
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- HY-N4221
-
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Others
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Others
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6'-O-Cinnamoyl harpagide is an iridoid glycoside isolated from the roots of Scrophularia ningpoensis .
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-
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- HY-N3839
-
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7-epi-Vogeloside; Nervoside; Epivogeloside
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Others
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Others
|
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epi-Vogeloside is a secoiridoid glycoside and a iridoid glucoside, which can be isolated from Lonicera japonica Thunb .
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- HY-N12202
-
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Others
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Others
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6′-O-β-D-Glucopyranosylphlorigidoside C (compound 1) is an iridoid glycoside that can be isolated from Lamiophlomis rotata .
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- HY-N2015R
-
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Reference Standards
Others
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Neurological Disease
|
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Hastatoside (Standard) is the analytical standard of Hastatoside. This product is intended for research and analytical applications. Hastatoside is an iridoid glycoside that is isolated from Verbena officinalis and has a role in promoting sleep .
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- HY-N0409R
-
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Reference Standards
Others
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Inflammation/Immunology
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Picroside III (Standard) is the analytical standard of Picroside III. This product is intended for research and analytical applications. Picroside III is an iridoid glycoside isolated from Picrorhiza scrophulariiflora (PS), a traditional Chinese medicine .
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-
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- HY-N0494R
-
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Gentiopicrin (Standard)
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Reference Standards
Cytochrome P450
HCV
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Inflammation/Immunology
|
|
Gentiopicroside (Standard) is the analytical standard of Gentiopicroside. This product is intended for research and analytical applications. Gentiopicroside, a naturally occurring iridoid glycoside, inhibits P450 activity, with an IC50 and a Ki of 61 μM and 22.8 μM for CYP2A6; Gentiopicroside has anti-inflammatoryand antioxidative effects.
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- HY-N3552
-
|
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NF-κB
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Inflammation/Immunology
|
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Catalposide, an iridoid glycoside that could be isolated from Catalpa ovate G. Don (Bignoniaceae), inhibits TNF-α, IL-1β, and IL-6 productions and NF-κB (p65) activation in lipopolysaccharide-activated RAW 264.7 macrophages .
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-
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- HY-126232
-
|
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NF-κB
TNF Receptor
IKK
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Infection
Inflammation/Immunology
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Verproside, a catalpol derivative iridoid glycoside isolated from the genus Pseudolysimachion, represses TNF-α -induced MUC5AC expression by inhibiting NF-κB activation via the IKK/IκB signaling cascade. Verproside has potent anti-inflammatory, antioxidant, antinociceptive and anti-asthmatic activities. Verproside has the potential for the study of chronic obstructive pulmonary disease (COPD) .
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- HY-N12203
-
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Others
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Others
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5-Deoxypulchelloside I is a magnoside glycoside that can be isolated from the aerial parts of the Lamiaceae plant Eremostachys laciniata .
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- HY-N6246R
-
|
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Reference Standards
NF-κB
ERK
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Inflammation/Immunology
Cancer
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Asperulosidic Acid (Standard) is the analytical standard of Asperulosidic Acid. This product is intended for research and analytical applications. Asperulosidic Acid (ASPA), a bioactive iridoid glycoside, is extracted from the herbs of Hedyotis diffusa Willd. Asperulosidic Acid (ASPA) has anti-tumor, anti-oxidant, and anti-inflammatory activities .
ASPA is related to the inhibition of inflammatory cytokines (TNF-α, IL-6) and mediators via suppression of the NF-κB and mitogen-activated protein kinase (MAPK) signaling pathways .
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-
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- HY-N0397R
-
|
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Reference Standards
Parasite
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Infection
Inflammation/Immunology
|
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Harpagide (Standard) is the analytical standard of Harpagide. This product is intended for research and analytical applications. Harpagide is a class of iridoid glycoside isolated from Scrophularia ningpoensis and has antiparasitic activity, which exhibits good in vitro trypanocidal activities against African trypanosomes (T.b. rhodesiense) with an IC50 of 21 μg/mL. Harpagide exerts significant antileishmanial activity against L. donovani with an IC50 value of 2.0 μg/mL. Harpagide also possess significant anti-inflammatory activities .
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-
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- HY-N0512R
-
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Loganoside (Standard)
|
Reference Standards
Apoptosis
Keap1-Nrf2
TNF Receptor
Interleukin Related
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Neurological Disease
Inflammation/Immunology
Cancer
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|
Loganin (Standard) is the analytical standard of Loganin. This product is intended for research and analytical applications. Loganin is a type of iridoid glycoside compound that possesses anti-inflammatory, antioxidant, and antitumor properties, and offers protective effects against acute lung injury and pulmonary fibrosis. Loganin exerts its protective effects against LPS (HY-D1056)-mediated inflammation and oxidative stress by upregulating the Nrf2/HO-1 signaling pathway, and it reduces neuroinflammation caused by spinal cord injury (SCI) .
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-
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- HY-N11712
-
|
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Others
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Others
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8-Dehydroxyshanzhiside is an iridoid glycoside that can be isolated from Lamiophlomis rotata .
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-
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- HY-N17900
-
|
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Others
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Others
|
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Secologanoside 7-methyl ester (compound 2) is an iridoid glycoside. Secologanoside 7-methyl ester can be found in the leaves of Syringa reticulata .
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-
-
- HY-N0631R
-
|
|
Reference Standards
Prostaglandin Receptor
ERK
p38 MAPK
Acyltransferase
TNF Receptor
COX
Cholinesterase (ChE)
Interleukin Related
JNK
NO Synthase
NF-κB
|
Neurological Disease
Inflammation/Immunology
|
|
Cornuside (Standard) is the analytical standard of Cornuside (HY-N0631). This product is intended for research and analytical applications. Cornuside is an iridoid glycoside with anti-allergic, anti-inflammatory, and neuroprotective activities. Cornuside exerts anti-allergic activity by downregulating the p38 MAPK, JNK, and NF-κB signaling pathways, and inhibits IgE-mediated histamine release from mast cells. Cornuside improves cognitive impairment in mice by inhibiting BACE1 activity (IC50 = 55.84 μg/mL) and enhancing ChAT activity. Cornuside inhibits LPS (HY-D1056)-induced inflammatory mediators, including iNOS, COX-2, PGE2, TNF-α, IL-6, and IL-1β, by suppressing NF-κB activation.
|
-
-
- HY-N0757R
-
|
|
Reference Standards
Akt
Bcl-2 Family
Apoptosis
Adrenergic Receptor
|
Cardiovascular Disease
Inflammation/Immunology
Cancer
|
|
8-O-Acetylharpagide (Standard) is the analytical standard of 8-O-Acetylharpagide. This product is intended for research and analytical applications. 8-O-Acetylharpagide is an iridoid glycoside compound. 8-O-Acetylharpagide exhibits anti-aging activity at low doses and anticancer activity at high doses. 8-O-Acetylharpagide induces late-stage apoptosis and necrosis-like death in cancer cells, and downregulates anti-apoptotic proteins such as Akt, p-Akt and Bcl-2. 8-O-Acetylharpagide is mainly metabolized in rats via demethylation, hydrolysis and glucuronidation, and its active metabolites downregulate the AKT/NF-κB/MMP9 signaling axis. 8-O-Acetylharpagide exerts vasoconstrictive effects by activating vascular α-adrenoceptor.
|
-
-
- HY-N0648R
-
|
|
Reference Standards
Interleukin Related
Heme Oxygenase (HO)
Keap1-Nrf2
NF-κB
Apoptosis
|
Inflammation/Immunology
|
|
Monotropein (Standard) is the analytical standard of Monotropein. This product is intended for research and analytical applications. Monotropein is an iridoid glycoside that can be isolated from the roots of Morinda officinalis. Monotropein inhibits the expression of inflammatory mediators in dextran sulfate sodium (DSS)-induced colitis mouse model. Monotropein exerts protective effects against IL-1β-induced apoptosis and catabolic responses on osteoarthritis chondrocytes. Monotropein has cartilage protective activity. Monotropein can alleviate Cisplatin (HY-17394)-induced acute kidney injury by inhibiting oxidative damage, inflammation and apoptosis through activation of Nrf2/HO-1 pathway and inhibition of NF-κB signaling. Monotropein can be studied in research for osteoarthritis, acute kidney injury and acute lung injury .
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-
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- HY-N0806R
-
|
|
Reference Standards
Keap1-Nrf2
AMPK
Sirtuin
NF-κB
NOD-like Receptor (NLR)
Pyroptosis
Apoptosis
Autophagy
PARP
|
Metabolic Disease
|
|
Sweroside (Standard) is the analytical standard of Sweroside (HY-N0806). This product is intended for research and analytical applications. Sweroside is an iridoid glycoside that targets multiple targets, including the Keap1/Nrf2 axis, NLRP3 inflammasome, SIRT1, NF-κB, AMPK/mTOR pathway, and caspase family. Sweroside promotes Nrf2 nuclear translocation by competitively binding to Keap1. Sweroside also inhibits oxidative stress and NLRP3-mediated pyroptosis by activating Nrf2, inhibits NF-κB inflammatory pathway by activating SIRT1, and promotes autophagy and induces caspase-dependent apoptosis via the AMPK/mTOR pathway. Sweroside has antioxidant, anti-inflammatory, anti-apoptotic, and lipid metabolism regulating activities, and can be used in the research of myocardial ischemia-reperfusion injury, leukemia, acute lung injury, non-alcoholic fatty liver disease, and other fields .
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-
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- HY-N19759
-
-
-
- HY-N19779
-
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Scrospioside A; Scropheanoside III
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Drug Derivative
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Metabolic Disease
|
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Scropolioside D (Scrospioside A; Scropheanoside III) is an orally active acylated iridoid glycoside found in the roots of Scrophularia saharae with antidiabetic activity .
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- HY-N17467
-
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Drug Derivative
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Metabolic Disease
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Forsydoitriside A is an iridoid glycoside trimer found in the fruits of Forsythia suspensa. Forsydoitriside A shows no significant hepatoprotective activity against Acetaminophen (HY-66005)-induced damage in liver cells at 10 μM .
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- HY-125543
-
|
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Others
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Others
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Karsoside is an iridoid glycoside that can be isolated from Scrophularia ilwensis .
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- HY-N18704
-
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Others
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Others
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Euphrasia officinalis extract contains iridoid glycosides and flavonoids, and can be used in cosmetic research.
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- HY-N18760
-
|
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Bacterial
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Infection
Inflammation/Immunology
|
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Vitex negundo extract is rich in bioactive compounds such as alkaloids, flavonoids, glycosides, volatile oils, triterpenoids, tannins, polyphenols, flavonoids, and iridoid glycosides. Vitex negundo extract possesses anti-inflammatory, antioxidant, antibacterial, and detoxifying properties.
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- HY-N9844
-
|
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Others
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Others
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Jaspolyanthoside is a trimeric iridoid glycoside can be found in the stems of Jasminum nervosum Lour. (Oleaceae). It lacks anti-inflammatory, antioxidant, and antitumor activities .
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- HY-N18004
-
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Others
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Others
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Deacetylasperuloside (Compound 4) is an glycoside found in Hedyotis chrysotricha (Palib) Merr .
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- HY-N2094R
-
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Genipin 1-gentiobioside (Standard); Genipin 1-β-gentiobioside (Standard); Genipin gentiobioside (Standard)
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Reference Standards
Others
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Inflammation/Immunology
|
|
Genipin 1-β-D-gentiobioside (Genipin 1-gentiobioside) is one of the most abundant and bioactive iridoid glycosides in Gardenia jasminoides Ellis, which possesses hepatoprotective, anti-inflammatory, antioxidant, and antithrombotic activities.
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- HY-182295
-
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Reactive Oxygen Species (ROS)
Apoptosis
MMP
Bacterial
Parasite
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Cardiovascular Disease
Infection
Neurological Disease
|
|
Negundoside is an iridoid glycoside compound. Negundoside exhibits hepatoprotective effects, reduces ROS, lipid peroxidation and intracellular calcium ion levels, and prevents the decrease of mitochondrial membrane potential (MMP) and apoptosis (apoptosis). Negundoside has neuroprotective effects, improves behavioral deficits, alleviates oxidative damage, and ameliorates cerebral infarction. Negundoside also possesses antibacterial and antiparasitic activities .
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- HY-N9731
-
|
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NF-κB
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Others
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6-O-p-Hydroxybenzoylglutinoside acts as a selective NF-κB inhibitor that suppresses the transcriptional activity of TNF-α-activated NF-κB (IC50=52.78 μM). 6-O-p-Hydroxybenzoylglutinoside shows no significant inhibitory activity against sEH, AChE, or BChE. 6-O-p-Hydroxybenzoylglutinoside is a caged chlorinated iridoid glycoside identified from the seeds of Catalpa bungei (Manchurian catalpa) .
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| Cat. No. |
Product Name |
Category |
Target |
Chemical Structure |
-
- HY-N0820
-
-
-
- HY-N0664
-
-
-
- HY-N0494
-
-
-
- HY-N0512
-
-
-
- HY-N6246
-
-
-
- HY-N0806
-
|
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Monophenols
Classification of Application Fields
Labiatae
Lespedeza tomentosa (Thunb.) Siebold ex Maxim.
Phenols
Metabolic Disease
Plants
Disease Research Fields
|
Keap1-Nrf2
AMPK
Sirtuin
NF-κB
NOD-like Receptor (NLR)
Pyroptosis
Apoptosis
Autophagy
PARP
|
|
Sweroside is an iridoid glycoside that targets multiple targets, including the Keap1/Nrf2 axis, NLRP3 inflammasome, SIRT1, NF-κB, AMPK/mTOR pathway, and caspase family. Sweroside promotes Nrf2 nuclear translocation by competitively binding to Keap1. Sweroside also inhibits oxidative stress and NLRP3-mediated pyroptosis by activating Nrf2, inhibits NF-κB inflammatory pathway by activating SIRT1, and promotes autophagy and induces caspase-dependent apoptosis via the AMPK/mTOR pathway. Sweroside has antioxidant, anti-inflammatory, anti-apoptotic, and lipid metabolism regulating activities, and can be used in the research of myocardial ischemia-reperfusion injury, leukemia, acute lung injury, non-alcoholic fatty liver disease, and other fields .
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-
-
- HY-N0631
-
|
|
Structural Classification
Iridoids
Cornaceae
Classification of Application Fields
Cornus officinalis Sieb. et Zucc.
Terpenoids
Phenols
Polyphenols
Plants
Inflammation/Immunology
Disease Research Fields
Source Classification
|
p38 MAPK
NF-κB
JNK
Cholinesterase (ChE)
Acyltransferase
NO Synthase
Interleukin Related
TNF Receptor
Prostaglandin Receptor
ERK
COX
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Cornuside is an iridoid glycoside with anti-allergic, anti-inflammatory, and neuroprotective activities. Cornuside exerts anti-allergic activity by downregulating the p38 MAPK, JNK, and NF-κB signaling pathways, and inhibits IgE-mediated histamine release from mast cells. Cornuside improves cognitive impairment in mice by inhibiting BACE1 activity (IC50 = 55.84 μg/mL) and enhancing ChAT activity. Cornuside inhibits LPS (HY-D1056)-induced inflammatory mediators, including iNOS, COX-2, PGE2, TNF-α, IL-6, and IL-1β, by suppressing NF-κB activation .
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- HY-N0914
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- HY-N0648
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- HY-N0757
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- HY-N2015
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- HY-N0397
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- HY-N2094
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- HY-N5070
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- HY-N5086
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- HY-N0409
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- HY-N8046
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- HY-N9352
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- HY-N0820R
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- HY-N0916
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- HY-N12840
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- HY-N6008
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- HY-N2712
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- HY-N1206
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- HY-121125
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- HY-133109
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- HY-N0914R
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- HY-N13109
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- HY-N11794
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- HY-N4221
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- HY-N3839
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- HY-N12202
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- HY-N2015R
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- HY-N0409R
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- HY-N0494R
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- HY-N3552
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- HY-126232
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- HY-N12203
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- HY-N6246R
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Structural Classification
Iridoids
Terpenoids
Rubiaceae
Plants
Morinda officinalis How
Source Classification
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Reference Standards
NF-κB
ERK
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Asperulosidic Acid (Standard) is the analytical standard of Asperulosidic Acid. This product is intended for research and analytical applications. Asperulosidic Acid (ASPA), a bioactive iridoid glycoside, is extracted from the herbs of Hedyotis diffusa Willd. Asperulosidic Acid (ASPA) has anti-tumor, anti-oxidant, and anti-inflammatory activities .
ASPA is related to the inhibition of inflammatory cytokines (TNF-α, IL-6) and mediators via suppression of the NF-κB and mitogen-activated protein kinase (MAPK) signaling pathways .
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- HY-N0397R
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Iridoids
Scrophularia ningpoensis Hemsl.
Terpenoids
Scrophulariaceae
Plants
Source Classification
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Reference Standards
Parasite
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Harpagide (Standard) is the analytical standard of Harpagide. This product is intended for research and analytical applications. Harpagide is a class of iridoid glycoside isolated from Scrophularia ningpoensis and has antiparasitic activity, which exhibits good in vitro trypanocidal activities against African trypanosomes (T.b. rhodesiense) with an IC50 of 21 μg/mL. Harpagide exerts significant antileishmanial activity against L. donovani with an IC50 value of 2.0 μg/mL. Harpagide also possess significant anti-inflammatory activities .
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- HY-N0512R
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- HY-N11712
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- HY-N17900
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- HY-N0631R
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Structural Classification
Iridoids
Cornaceae
Cornus officinalis Sieb. et Zucc.
Terpenoids
Phenols
Polyphenols
Plants
Source Classification
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Reference Standards
Prostaglandin Receptor
ERK
p38 MAPK
Acyltransferase
TNF Receptor
COX
Cholinesterase (ChE)
Interleukin Related
JNK
NO Synthase
NF-κB
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Cornuside (Standard) is the analytical standard of Cornuside (HY-N0631). This product is intended for research and analytical applications. Cornuside is an iridoid glycoside with anti-allergic, anti-inflammatory, and neuroprotective activities. Cornuside exerts anti-allergic activity by downregulating the p38 MAPK, JNK, and NF-κB signaling pathways, and inhibits IgE-mediated histamine release from mast cells. Cornuside improves cognitive impairment in mice by inhibiting BACE1 activity (IC50 = 55.84 μg/mL) and enhancing ChAT activity. Cornuside inhibits LPS (HY-D1056)-induced inflammatory mediators, including iNOS, COX-2, PGE2, TNF-α, IL-6, and IL-1β, by suppressing NF-κB activation.
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- HY-N0757R
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Structural Classification
other families
Iridoids
Terpenoids
Plants
Source Classification
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Reference Standards
Akt
Bcl-2 Family
Apoptosis
Adrenergic Receptor
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8-O-Acetylharpagide (Standard) is the analytical standard of 8-O-Acetylharpagide. This product is intended for research and analytical applications. 8-O-Acetylharpagide is an iridoid glycoside compound. 8-O-Acetylharpagide exhibits anti-aging activity at low doses and anticancer activity at high doses. 8-O-Acetylharpagide induces late-stage apoptosis and necrosis-like death in cancer cells, and downregulates anti-apoptotic proteins such as Akt, p-Akt and Bcl-2. 8-O-Acetylharpagide is mainly metabolized in rats via demethylation, hydrolysis and glucuronidation, and its active metabolites downregulate the AKT/NF-κB/MMP9 signaling axis. 8-O-Acetylharpagide exerts vasoconstrictive effects by activating vascular α-adrenoceptor.
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- HY-N0648R
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- HY-N0806R
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Structural Classification
Monophenols
Labiatae
Lespedeza tomentosa (Thunb.) Siebold ex Maxim.
Phenols
Plants
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Reference Standards
Keap1-Nrf2
AMPK
Sirtuin
NF-κB
NOD-like Receptor (NLR)
Pyroptosis
Apoptosis
Autophagy
PARP
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Sweroside (Standard) is the analytical standard of Sweroside (HY-N0806). This product is intended for research and analytical applications. Sweroside is an iridoid glycoside that targets multiple targets, including the Keap1/Nrf2 axis, NLRP3 inflammasome, SIRT1, NF-κB, AMPK/mTOR pathway, and caspase family. Sweroside promotes Nrf2 nuclear translocation by competitively binding to Keap1. Sweroside also inhibits oxidative stress and NLRP3-mediated pyroptosis by activating Nrf2, inhibits NF-κB inflammatory pathway by activating SIRT1, and promotes autophagy and induces caspase-dependent apoptosis via the AMPK/mTOR pathway. Sweroside has antioxidant, anti-inflammatory, anti-apoptotic, and lipid metabolism regulating activities, and can be used in the research of myocardial ischemia-reperfusion injury, leukemia, acute lung injury, non-alcoholic fatty liver disease, and other fields .
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- HY-N19759
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- HY-N19779
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- HY-N17467
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- HY-125543
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- HY-N18704
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- HY-N18760
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Structural Classification
Extract
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Bacterial
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Vitex negundo extract is rich in bioactive compounds such as alkaloids, flavonoids, glycosides, volatile oils, triterpenoids, tannins, polyphenols, flavonoids, and iridoid glycosides. Vitex negundo extract possesses anti-inflammatory, antioxidant, antibacterial, and detoxifying properties.
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- HY-N9844
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- HY-N18004
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- HY-N2094R
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- HY-N9731
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