1 Result for "

KB-V1

" in MedChemExpress (MCE) Product Catalog:
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1 Results for "KB-V1" in MCE Product Catalog:

10S,13aR-Antofine N-oxide
10S,13aR-Antofine N-oxide
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Cat. No.: HY-N17304
CAS No.: 314744-17-7
Category:  

Alkaloids Other Alkaloids Plants Cynanchum vincetoxicum (L.) Pers. Apocynaceae Extract

Target:  

Drug Derivative P-glycoprotein

10S,13aR-Antofine N-oxide is a phenanthroindolizidine N-oxide alkaloid and cytotoxic agent found in Cynanchum vincetoxicum. 10S,13aR-Antofine N-oxide exerts cytotoxic effects in drug-sensitive (KB-3-1, IC50 = 0.11 μM) and multi-drug-resistant (KB-V1, IC50 = 0.16 μM) carcinoma cells. 10S, 13aR-Antofine N-oxide acts as a poor substrate for the P-glycoprotein (P-170) efflux pump. 10S,13aR-Antofine N-oxide can be used for the research of cancers [1].
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