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LS174T

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (1) Antibiotic (1) Antibody-Drug Conjugates (ADCs) (1) Apoptosis (3) Bacterial (1) BMI1 (1) CD73 (1) CDK (3) Dan family (1) Drug Derivative (1) Endogenous Metabolite (1) Epigenetic Reader Domain (2) Microtubule/Tubulin (1) Nucleoside Antimetabolite/Analog (1) Parasite (1) PASK/STK37 (1) Peptide-Drug Conjugates (PDCs) (1) PKA (1) PROTACs (2) Radionuclide-Drug Conjugates (RDCs) (1) Reference Standards (1) STAT (1) Transketolase (1) Wnt (1)
By Research Areas:	Cancer (15) Infection (3) Inflammation/Immunology (1)
Oligonucleotides:	Nucleoside Analogs (1)

Inhibitors & Agonists

Peptides

Inhibitory Antibodies

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-107425

MZ 1 20+ Cited Publications	PROTACs Epigenetic Reader Domain	Cancer
MZ 1 is a PROTAC connected by ligands for von Hippel-Lindau and BRD4. MZ 1 potently and rapidly induces reversible, long-lasting, and selective removal of BRD4 over BRD2 and BRD3. K_ds of 382/120, 119/115, and 307/228 nM for BRD4 BD1/2, BRD3 BD1/2, and BRD2 BD1/2, respectively .

HY-14392

5,6-Dichlorobenzimidazole riboside 5+ Cited Publications DRB	CDK Apoptosis	Cancer
5,6-Dichlorobenzimidazole riboside (DRB) is a nucleoside analog that inhibits several carboxyl-terminal domain kinases, including casein kinase II and cell cycle-dependent kinases (CDK). 5, 6-dichlorobenzimidazole riboside has antitumor activity. 5, 6-dichlorobenzimidazole riboside can induce apoptosis .

HY-P99643

Ginisortamab UCB6114	Dan family	Cancer
Ginisortamab (UCB6114) is a fully human IgG4P anti Gremlin-1 monoclonal antibody, with mean IC₅₀ values of 8.2 nM and 9 nM against human and mouse gremlin-1, respectivly. Ginisortamab inhibits gremlin-1 antagonism of BMP signaling pathways. Ginisortamab has the potential for the research of gastrointestinal (GI) tumors .

HY-P99681

Labetuzumab govitecan IMMU 130; hMN-14-SN-38	Antibody-Drug Conjugates (ADCs)	Cancer
Labetuzumab govitecan (IMMU 130) is an Anti-CEACAM5/SN-38 antibody-drug conjugate (ADC). Labetuzumab govitecan consists of the antibody Labetuzumab, SN-38, and a pH-sensitive Linker. Labetuzumab govitecan can be used for research of cancers, such as colorectal cancer .

HY-153090

Transketolase-IN-4	Transketolase	Infection Cancer
Transketolase-IN-4 is a potent inhibitor of transketolase with an IC₅₀ value of 3.9 μM. Transketolase-IN-4 inhibits the proliferation of tumor cells including SW620, LS174T and MIA PaCa-2. Transketolase-IN-4 can be used for tumor research .

HY-P10364

Ubiquicidin(29-41) UBI(29-41)	Bacterial Antibiotic	Infection Inflammation/Immunology
Ubiquicidin (29-41) (UBI (29-41)) is an Antimicrobial peptide and infection-localizing agent. Ubiquicidin (29-41) acts as an infection-specific imaging agent and infection-targeting agent. Ubiquicidin (29-41) serves as an antibiotic efficacy monitoring agent, and its aggregation level in infections induced by Staphylococcus aureus is higher than that in infections induced by Escherichia coli .

HY-117361

LY207702	Nucleoside Antimetabolite/Analog	Cancer
LY207702 is a difluorinated purine nucleoside with antitumor activity and cardiotoxicity. LY207702 is cytotoxic to CEA-positive LS174T cells (IC₅₀=0.302 μg/mL). LY207702 can be used in the study of colon cancer .

HY-137632

Sp-8-Cl-cAMPS	PKA	Cancer
Sp-8-Cl-cAMPS is an analog of cAMP (HY-B1511) and a derivative of Sp-8-Cl-cAMP. Sp-8-Cl-cAMPS inhibits the growth of human leukemia cell HL-60 and colon cancer cell LS-174T, with IC₅₀ of 8-100 μM. Sp-8-Cl-cAMPS activates the protein kinases cAKI and cAKII, with K_a of 0.25 and 3.2 μM .

HY-P10760

PhAc-ALGP-Dox	Peptide-Drug Conjugates (PDCs)	Cancer
PhAc-ALGP-Dox, a peptide-drug conjugate, is a novel anticancer prodrug, with IC₅₀ values ranged from 311 nM to 34.25 μM for TNBC (E0771), normal murine epithelium (HC-11), human TNBC (MDA-MB-231 and MDA-MB-468), human CrC (LS 174T), normal human epithelium (HME-1) cells .

HY-P2965

L-Lysine α-oxidase	Endogenous Metabolite	Cancer
L-Lysine α-oxidase is a potent anticancer agent. L-Lysine α-oxidase also a L-amino acid oxidase, deaminates L-lysine with the yield of H2O2, ammonia, and α-keto-ε-aminocaproate. L-Lysine α-oxidase shows cytotoxicity and anticancer activity .

HY-151433

Antiparasitic agent-10	Parasite	Infection
Antiparasitic agent-10 (Compound 94) is an anti-parasitic agent, shows anti-schistosomal activity. Antiparasitic agent-10 shows activity against adults of Schistosoma mansoni, and can be used in Schistosomiasis research .

HY-111207

CA224	CDK Apoptosis	Cancer
CA224 (Compound 1) is a selective and orally active Cdk4–cyclin D1 inhibitor with an IC₅₀ of 6.2 µM. CA224 induces cell apoptosis and shows antitumor activity .

HY-172617

APD-94	BMI1 Microtubule/Tubulin Apoptosis	Cancer
APD-94 is a dual inhibitor targeting tubulin and Bmi-1. APD-94 interfers tubulin normal polymerization. APD-94 suppresses the expression of Bmi-1. APD-94 causes cell cycle arrest at the G2/M phase in cancer cells and induces apoptosis, thus inhibiting cancer cell proliferation. APD-94 represses the growth of HT29 cell xenografts in NOD/SCID mice. APD-94 can be used for colorectal cancer study .

HY-171186

EAPB0202	Drug Derivative	Cancer
EAPB0202 is an imidazolium and quinoxaline derivative. EAPB0202 shows significant cytotoxicity to A375 human melanoma cell line with an IC₅₀ of 2.35 μM. EAPB0202 can be used in the study of cancer .

HY-107425R

MZ 1 (Standard)	Reference Standards PROTACs Epigenetic Reader Domain	Cancer
MZ 1 (Standard) is the analytical standard of MZ 1 (HY-107425). This product is intended for research and analytical applications. MZ 1 is a PROTAC connected by ligands for von Hippel-Lindau and BRD4. MZ 1 potently and rapidly induces reversible, long-lasting, and selective removal of BRD4 over BRD2 and BRD3. K_ds of 382/120, 119/115, and 307/228 nM for BRD4 BD1/2, BRD3 BD1/2, and BRD2 BD1/2, respectively .

HY-181919

CD73-IN-22	CD73 Radionuclide-Drug Conjugates (RDCs)	Cancer
CD73-IN-22 (Compound HX-6) is a non-nucleoside CD73 inhibitor with an IC₅₀ of 0.07 μM. When radiolabeled with ⁶⁸Ga, CD73-IN-22 acts as a PET radiotracer for detecting CD73 expression. When radiolabeled with ¹⁷⁷Lu, CD73-IN-22 exhibits anticancer activity against colorectal adenocarcinoma. CD73-IN-22 is applicable to research related to colon adenocarcinoma and breast cancer .

HY-114178

CDK8-IN-2	CDK STAT Wnt 5-HT Receptor PASK/STK37	Cancer
CDK8-IN-2 is an orally active CDK8 inhibitor of an IC₅₀ values of 0.010 μM. CDK8-IN-2 shows a CDK19 IC₅₀ value of 0.026 μM. CDK8-IN-2 inhibits phospho-STAT1, a pharmacodynamic biomarker of CDK8. CDK8-IN-2 inhibits WNT pathway activity. CDK8-IN-2 can be used for the research of colorectal carcinoma .

Cat. No.	Product Name	Target	Research Area

HY-P10364

Ubiquicidin(29-41) UBI(29-41)	Bacterial Antibiotic	Infection Inflammation/Immunology
Ubiquicidin (29-41) (UBI (29-41)) is an Antimicrobial peptide and infection-localizing agent. Ubiquicidin (29-41) acts as an infection-specific imaging agent and infection-targeting agent. Ubiquicidin (29-41) serves as an antibiotic efficacy monitoring agent, and its aggregation level in infections induced by Staphylococcus aureus is higher than that in infections induced by Escherichia coli .

HY-P10760

PhAc-ALGP-Dox	Peptide-Drug Conjugates (PDCs)	Cancer
PhAc-ALGP-Dox, a peptide-drug conjugate, is a novel anticancer prodrug, with IC₅₀ values ranged from 311 nM to 34.25 μM for TNBC (E0771), normal murine epithelium (HC-11), human TNBC (MDA-MB-231 and MDA-MB-468), human CrC (LS 174T), normal human epithelium (HME-1) cells .

Cat. No.	Product Name	Target	Research Area	Image

HY-P99643

Ginisortamab UCB6114	Dan family	Cancer
Ginisortamab (UCB6114) is a fully human IgG4P anti Gremlin-1 monoclonal antibody, with mean IC₅₀ values of 8.2 nM and 9 nM against human and mouse gremlin-1, respectivly. Ginisortamab inhibits gremlin-1 antagonism of BMP signaling pathways. Ginisortamab has the potential for the research of gastrointestinal (GI) tumors .

Cat. No.	Product Name		Classification

HY-14392

5,6-Dichlorobenzimidazole riboside 5+ Cited Publications DRB		Nucleoside Analogs
5,6-Dichlorobenzimidazole riboside (DRB) is a nucleoside analog that inhibits several carboxyl-terminal domain kinases, including casein kinase II and cell cycle-dependent kinases (CDK). 5, 6-dichlorobenzimidazole riboside has antitumor activity. 5, 6-dichlorobenzimidazole riboside can induce apoptosis .

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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