3 Results for "

Lethal factor

" in MedChemExpress (MCE) Product Catalog:
Products (3)

3 Results for "Lethal factor" in MCE Product Catalog:

Bepafant
Bepafant
0 Images
Cat. No.: HY-121007
CAS No.: 114776-28-2
Synonyms: Web2170
Target:  

Platelet-activating Factor Receptor (PAFR)

Research Areas:  

Others

Bepafant (Web2170) is a platelet-activating factor (PAF) antagonist that protects against anaphylactic lethality in active and passive anaphylaxis models in mice and guinea pigs in a dose-dependent manner and attenuates bronchoconstriction and blood pressure changes in anaphylaxis.
loading...
    loading...
View All Sizes
IN-2-LF
IN-2-LF
0 Images
Cat. No.: HY-P10150
CAS No.: 749879-64-9
Target:  

Bacterial

Research Areas:  

Infection

IN-2-LF is an inhibitor of lethal factor. IN-2-LF also inhibits furin with an IC50 of 2 μM. IN-2-LF enhances protection against anthrax lethal toxin when in combination with D6R .
loading...
    loading...
View All Sizes
PRT543
PRT543
0 Images
Cat. No.: HY-141876
CAS No.: 2278356-90-2
Target:  

Histone Methyltransferase Notch PI3K Akt Bcl-2 Family DNA/RNA Synthesis

Research Areas:  

Cancer

PRT543 is an orally active selective PRMT5 inhibitor. PRT543 reduces intracellular symmetric dimethylarginine (sDMA) levels, downregulates the expression of genes related to DNA damage repair and DNA replication pathways, and induces abnormal alternative splicing. PRT543 inhibits the MYB, NOTCH1 and PI3K/AKT signaling pathways, promotes nuclear translocation of FOXO1, upregulates the pro-apoptotic protein BAX, and enhances cellular sensitivity to BCL-2 inhibition. PRT543 disrupts the normal RNA splicing process and exerts a synthetic lethal effect on myeloid tumor cells carrying splicing factor mutations. PRT543 can be used in research related to various cancers including breast cancer, ovarian cancer and acute myeloid leukemia .
loading...
    loading...
View All Sizes
Assay Types