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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
8 Results for "
Liver Receptor Homolog-1
" in MedChemExpress (MCE) Product Catalog:
Products (8)
8 Results for "Liver Receptor Homolog-1" in MCE Product Catalog:
5
Target:
Research Areas:
ML-180 (SR1848) is a potent orphan nuclear receptor liver receptor homolog 1 (LRH-1; NR5A2) inverse agonist with an IC50 of 3.7 μM. ML-180 is inactive for steroidogenic factor-1 (SF-1; NR5A1; IC50>10 μM). ML-180 has the potential for LRH-1-dependent cancers .
2
2 Cited Publications
Target:
Research Areas:
RJW100 is a potent liver receptor homolog 1 (LRH-1, NR5A2) and steroidogenic factor-1 (SF-1, NR5A1) agonist with pEC50s of 6.6 and 7.5, respectively . RJW100 also causes strong activation of the miR-200c (miRNA-200c, microRNA-200c) promoter .
1
1 Cited Publications
Target:
Research Areas:
RR-RJW100, the enantiomer of RJW100, is an nuclear receptor liver receptor homolog 1 (LRH-1) and steroidogenic factor 1 (SF-1) agonist. RJW100 can be synthesized as two enantiomers, RR-RJW100 and SS-RJW100, with RR-RJW100 shown to be the more potent LRH-1 agonist. RR-RJW100 is involved in the regulation of metabolic homeostasis and is used in studies of diabetes, liver disease and inflammatory bowel disease .
1
1 Cited Publications
Target:
Research Areas:
7-[4-(2-Piperidinyl)ethoxy]benzoyl Raloxifene is a liver receptor homolog-1 (LRH-1) antagonist with an IC50 of 3.1 μM .
Cat. No.: HY-147105A
Research Areas:
(+)-LRH-1 modulator-1 is a stereoisomer of LRH-1 modulator-1. LRH-1 modulator-1 (compound 6N) is a potent LRH-1 (liver receptor homolog-1) modulator/agonist. LRH-1 modulator-1 has anti-inflammatory effects in intestinal organoids. LRH-1 modulator-1 induces the anti-inflammatory cytokine IL-10 and reduces the inflammatory cytokines IL-1b and TNFa .
Cat. No.: HY-131445A
Purity: 99.91%
Target:
Research Areas:
SS-RJW100 is a enantiomer of RJW100, which is a racemic agonist of nuclear receptor liver receptor homolog 1 (LRH-1) and steroidogenic factor 1 (SF-1). SS-RJW100 promotes recruitment of coregulator protein fragments in vitro, recruits the transcriptional intermediary factor 2 (Tif2) coactivator to LRH-1. SS-RJW100 diminishes LRH-1 allosteric activation networks, shows poor thermal stability .
Cat. No.: HY-P706317
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: Nuclear Receptor subfamily 5 group A member; Fetoprotein transcription factor (mFTF); Liver Receptor Homolog 1 (LRH-1); Nr5a2; Ftf; Lrh1
Species:
Mouse
Source:
E. coli
Cat. No.: HY-P810473
Synonyms: Nuclear Receptor Subfamily 5 Group A Member 2, LRH-1, FTZ-F1beta, FTZ-F1, HB1F-2, HB1F, B1F2, LRH1, FTF, CYP7A Promoter-Binding Factor, B1F, CPF, B1-Binding Factor, Hepatocyte Transcription Factor Which Activates Enhancer II Of Hepatitis B Virus, Nuclear Receptor Subfamily 5, Group A, Member 2, Fetoprotein-Alpha 1 (AFP) Transcription Factor, Alpha-1-Fetoprotein Transcription Factor, Hepatocytic Transcription Factor HB1F-3, Hepatocytic Transcription Factor, Liver Receptor Homolog-1, Liver Receptor Homolog 1, B1-Binding Factor
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
