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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
251 Results for "
Low-affinity
" in MedChemExpress (MCE) Product Catalog:
Products (251)
251 Results for "Low-affinity" in MCE Product Catalog:
44
44 Publications Verification
Research Areas:
ANA-12 is a brain-penetrant, selective TrkB antagonist with IC50 values of 45.6 nM and 41.1 μM, and Kd values of 10 nM and 12 μM, for high- and low-affinity sites, respectively. ANA-12 specifically inhibits BDNF-induced TrkB receptor activation and its downstream signaling cascades by directly and non-competitively binding to the TrkB receptor, without affecting the functions of TrkA and TrkC. ANA-12 is used in research concerning neuropsychiatric disorders (such as depression and anxiety), acute and chronic pain, neuroimmune inflammation, and the mechanisms of learning and memory .
10
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8
8 Cited Publications
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MRS 1754 is a selective antagonist radioligand for A2B adenosine receptor with very low affinity for A1 and A3 receptors of both humans and rats .
3
3 Cited Publications
Ch55 is a potent synthetic retinoid. Ch55 binds to RAR-α and RAR-β receptors with high affinity. Ch55 displays low affinity for cellular retinoic acid binding protein (CRABP). Ch55 is a potent inducer of the differentiation of HL60 cells with an EC50 of 200 nM. Ch55 can be used for cancer research .
3
3 Cited Publications
Cat. No.: HY-16688
CAS No.: 66611-26-5
Target:
Research Areas:
RU 24969 is a preferential 5-HT1B agonist, with a Ki of 0.38 nM, but also displays appreciable affinity for the 5-HT1A receptor (Ki=2.5 nM), and has low affinity for other receptor sites in the brain. RU 24969 could decrease fluid consumption and increase forward locomotion .
3
2
2 Cited Publications
Category:
Leguminosae/Fabaceae Extract Plant Flavonoids Abrus precatorius Linn. Extract Flavones Phenols Polyphenols
Target:
2
2 Cited Publications
Target:
Research Areas:
A2ti-2 is a selective and low-affinity annexin A2/S100A10 heterotetramer (A2t) inhibitor with an IC50 of 230 μM . A2ti-2 specifically disrupts the protein-protein interaction (PPI) between A2 and S100A10. A2ti-2 prevents human papillomavirus type 16 (HPV16) infection .
2
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Tiotidine (ICI 125211) is a potent and selective antagonist of histamine H2-receptor (pA2=7.3-7.8 for guinea-pig right atrium). Tiotidine has low affinity for both the H1 and the H3 receptors .
1
1 Cited Publications
Cat. No.: HY-P99300
CAS No.: 1322627-61-1
Synonyms: QGE 031; Anti-IGHE Recombinant Antibody
Target:
Research Areas:
1
Target:
1
1 Cited Publications
Cat. No.: HY-P7267
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: PPBP; Macrophage-Derived Growth Factor; Prev. THBGB1; C-X-C Motif Chemokine 7; SCYB7; Beta-Thromboglobulin; CTAP3; NAP-2-L1; CXCL7; Small Inducible Cytokine Subfamily B, Member 7; MDGF; Neutrophil-Activating Peptide-2; LDGF; Low-affinity Platelet Factor I
Species:
Human
Source:
CHO
1
1 Cited Publications
Cat. No.: HY-P75698
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: PPBP; Macrophage-Derived Growth Factor; Prev. THBGB1; C-X-C Motif Chemokine 7; SCYB7; Beta-Thromboglobulin; CTAP3; NAP-2-L1; CXCL7; Small Inducible Cytokine Subfamily B, Member 7; MDGF; Neutrophil-Activating Peptide-2; LDGF; Low-affinity Platelet Factor I
Species:
Mouse
Source:
E. coli
1
1 Cited Publications
Cat. No.: HY-P70705
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: FCGR3A; CD16; Prev. FCGR3; Fc Fragment Of IgG, Low affinity IIIa, Receptor For (CD16); Prev. FCG3; Fc Of IgG Low affinity IIIa Receptor Isoform 2; FcgammaRIIIa; Fc Of IgG Low affinity IIIa Receptor Isoform 1; FcGRIIIA; Immunoglobulin G Fc Receptor III; CD16a; Neutrophil-Specific Antigen NA; Low affinity Immunoglobulin Gamma Fc Region Receptor III-A; Fc-Gamma Receptor IIIb (CD16); Fc Fragment Of IgG, Low affinity IIIa, Receptor (CD16a); Fc Gamma Receptor III-A; Fc Fragment Of IgG Receptor IIIa; Fc-Gamma RIIIa; IgG Fc Receptor III-A; Fc-Gamma RIII; IgG Fc Receptor III-2; FcgammaRIIIA; Fc-Gamma RIII-Alpha; FCRIIIA; CD16a Antigen; FcRIIIa; CD16-II; FcR-10; IGFR3; FcRIII; CD16A; IMD20; Fc Gamma Receptor IIIa; Low affinity Immunoglobulin Gamma Receptor III-A Fc Fragment
Species:
Human
Source:
HEK293
1
1 Cited Publications
Cat. No.: HY-18006
CAS No.: 177707-12-9
Target:
Neurokinin Receptor Wnt Bcl-2 Family β-catenin Cyclin G-associated Kinase (GAK) VEGFR Caspase Cadherin Apoptosis
Research Areas:
Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
NKP608 is a non-peptidic derivative of 4-aminopiperidine, a highly selective, orally active, neurokinin-1 (NK1) receptor antagonist with IC50 of 2.6 nM. NKP608 is active both in vitro and in vivo, showing extremely low affinity for NK2, NK3 receptors. NKP608 exerts its effects by blocking the NK₁ receptor, regulate cell proliferation and apoptosis, affect neurotransmitter functions and gastric mucosal repair mechanisms, and suppress the Wnt/β-catenin pathway in antitumor research. NKP608 is applicable to research related to various diseases, including cough, anxiety disorders, depression, gastric mucosal injury, and colorectal cancer .
Synonyms: GSK189075
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Remogliflozin etabonate (GSK189075) is an orally active, selective and low-affinity sodium glucose cotransporter (SGLT2) inhibitor with Ki values of 1.95 μM, 2.14 μM, 43.1 μM, 8.57 μM for hSGLT2, rSGLT2, hSGLT1, rSGLT1, respectively. Remogliflozin etabonate is a proagent based on benzylpyrazole glucoside and is metabolized to its active form, Remogliflozin, in the body. Remogliflozin etabonate exhibits antidiabetic efficacy in rodent models .
Category:
Cardiovascular Disease Plant Digitalis purpurea L. Extract Plantaginaceae Extract Scrophulariaceae Extract Disease Research Fields Steroids
Target:
Cat. No.: HY-B1128A
CAS No.: 30034-03-8
Synonyms: Cephamandole sodium
Research Areas:
Cefamandole sodium (Cephamandole sodium) is a β-lactam antibiotic with broad-spectrum antibacterial activity. Cefamandole sodium resists hydrolysis by β-lactamase of some Gram-negative bacteria. Cefamandole sodium binds with high affinity to major penicillin-binding proteins (PBP) and with low affinity to PBP 2a, induces the production of low-affinity PBP associated with Methicillin (HY-121544) resistance, and blocks peptidoglycan biosynthesis through the SecA subunit of PBP. Cefamandole sodium can be used in research related to bacterial infections .
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Pipamperone (Floropipamide) is a butyrophenone derivative and high-affinity antagonist of 5-HT2A receptor (pKi=8.2) and D4 receptor (pKi=8.0). Pipamperone is also a low-affinity antagonist of D2 receptor (pKi=6.7). Pipamperone affects neurotransmitter functions and exerts antipsychotic activity. Pipamperone is used in the research of mental disorders such as autism-related behavioral disorders and Alzheimer's disease .
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CPCCOEt is a low affinity, selective, non-competitive and reversible antagonist of metabotropic glutamate receptor 1b (mGluR1b) .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
