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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
11 Results for "
M1R
" in MedChemExpress (MCE) Product Catalog:
Products (11)
11 Results for "M1R" in MCE Product Catalog:
Target:
Research Areas:
TAK-071 is a novel, potent and highly selective muscarinic acetylcholine receptor 1 (M1R) positive allosteric modulator. EC50 of TAK-071 M1R agonist activities is 520 nM [1].
Cat. No.: HY-183487
CAS No.: 2257498-40-9
Target:
Research Areas:
M1R modulator-1 is an orally effective positive allosteric modulator of muscarinic M1R, with an IP value of 0.88 nM. M1R modulator-1 can be used in constipation-related research [1].
Cat. No.: HY-B0462C
CAS No.: 153408-28-7
Target:
Research Areas:
(R)-Azelastine hydrochloride, an antihistamine, has been demonstrated to down-regulate the levels of H1R, M1R, and M3R, while also inhibiting the proliferation of HNEpC.
Cat. No.: HY-Z12728
CAS No.: 143228-84-6
Target:
Research Areas:
(R)-Azelastine is an antihistamine compound with antiallergic activity. (R)-Azelastine can downregulate the levels of H1R, M1R, and M3R. (R)-Azelastine has also been shown to inhibit the proliferation of HNEpC [1].
Cat. No.: HY-B0462D
CAS No.: 143228-85-7
Synonyms: (+)-Azelastine
Target:
Research Areas:
(S)-Azelastine ((+)-Azelastine) is an antihistamine with antiallergic and antiasthmatic activity. (S)-Azelastine has been shown to downregulate H1R, M1R, and M3R levels. (S)-Azelastine also has the property of inhibiting HNEpC proliferation [1].
Cat. No.: HY-P703771
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: M1R
Species:
Virus
Source:
HEK293
Cat. No.: HY-RS02660
Target:
Research Areas:
CHRM1 Human Pre-designed siRNA Set A contains three designed siRNAs for CHRM1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS18169
Target:
Research Areas:
Chrm1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Chrm1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-P703102
Purity: ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: CHRM1; Muscarinic Acetylcholine Receptor; Cholinergic Receptor Muscarinic 1; HM1; Acetylcholine Receptor, Muscarinic 1; M1R; Muscarinic Acetylcholine Receptor M1; M1
Species:
Human
Source:
HEK293
Cat. No.: HY-187957
Research Areas:
M1/M4 muscarinic agonist 4 is a dual-site muscarinic acetylcholine receptor ligand with potent agonistic activity at M1/M4 muscarinic acetylcholine receptors. M1/M4 muscarinic agonist 4 activates M1R to induce phosphorylation of ERK1/2, and activates M4R to induce GαoB protein activation as well as ERK1/2 phosphorylation. M1/M4 muscarinic agonist 4 exhibits higher binding affinity for M4R than for other muscarinic receptors, while its binding affinity for the W435A mutant M4R is reduced. M1/M4 muscarinic agonist 4 can be used in the research of schizophrenia [1].
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
