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Cat. No.: HY-183487

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M1R modulator-1

M1R modulator-1 is an orally effective positive allosteric modulator of muscarinic M1R, with an IP value of 0.88 nM. M1R modulator-1 can be used in constipation-related research.

For research use only. We do not sell to patients.

CAS No.: 2257498-40-9
Formula: C₂₃H₂₃N₅O₄
Molecular Weight:433.47

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

M1R modulator-1 Chemical Structure

CAS No.: 2257498-40-9

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
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Bioz

Biological Activity

Description

M1R modulator-1 is an orally effective positive allosteric modulator of muscarinic M1R, with an IP value of 0.88 nM. M1R modulator-1 can be used in constipation-related research^[1].

All mAChR Isoforms :

In Vivo

M1R modulator-1 (Example 20) (1-3 mg/kg; p.o.; single administration) significantly increases the defecation frequency in rats^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Male SD rats (aged 5-6 weeks) after approximately 1 week of acclimatization period^[1]
Dosage:

1 and 3 mg/kg
Administration:

p.o.; single administration
Result:

Significantly increased the defecation frequency in rats.

Chemical Information

CAS No. 2257498-40-9
Molecular Weight 433.47
Formula C₂₃H₂₃N₅O₄
SMILES

C(C1=C2C(=NC(C(N[C@@H]3[C@@H](O)COCC3)=O)=C1)C=CO2)C4=CC=C(C=C4)C=5N=NN(C)C5
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Kazuyoshi, W., et al. Heterocyclic compounds useful for prevention or treatment of constipation and the like. WO2018235838A1.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
- In Vivo
Chemical Information
Purity & Documentation
References

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M1R modulator-1

All mAChR Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

M1R modulator-1 Related Classifications

HY-183487 Related Classifications