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Art. -Nr.: HY-183487

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M1R modulator-1

M1R modulator-1 is an orally effective positive allosteric modulator of muscarinic M1R, with an IP value of 0.88 nM. M1R modulator-1 can be used in constipation-related research.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

CAS. Nr.: 2257498-40-9
Formel: C₂₃H₂₃N₅O₄
Molecular Weight:433.47

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

M1R modulator-1 Chemical Structure

CAS. Nr.: 2257498-40-9

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

M1R modulator-1 is an orally effective positive allosteric modulator of muscarinic M1R, with an IP value of 0.88 nM. M1R modulator-1 can be used in constipation-related research^[1].

Alle mAChR Isoform-spezifische Produkte anzeigen :

In Vivo

M1R modulator-1 (Example 20) (1-3 mg/kg; p.o.; single administration) significantly increases the defecation frequency in rats^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Male SD rats (aged 5-6 weeks) after approximately 1 week of acclimatization period^[1]
Dosage:

1 and 3 mg/kg
Administration:

p.o.; single administration
Result:

Significantly increased the defecation frequency in rats.

Chemical Information

CAS. Nr. 2257498-40-9
Molecular Weight 433.47
Formel C₂₃H₂₃N₅O₄
SMILES

C(C1=C2C(=NC(C(N[C@@H]3[C@@H](O)COCC3)=O)=C1)C=CO2)C4=CC=C(C=C4)C=5N=NN(C)C5
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Kazuyoshi, W., et al. Heterocyclic compounds useful for prevention or treatment of constipation and the like. WO2018235838A1.

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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MOQ

Minimum order quantity

100 mg

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