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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
113 Results for "
MAD
" in MedChemExpress (MCE) Product Catalog:
Products (113)
113 Results for "MAD" in MCE Product Catalog:
5
5 Cited Publications
Cat. No.: HY-P71323
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: SMAD3; MAD, Mothers Against Decapentaplegic Homolog 3; Prev. MADH3; SMAD, Mothers Against DPP Homolog 3; JV15-2; SMA- And MAD-Related Protein 3; HsT17436; Mothers Against DPP Homolog; Mothers Against Decapentaplegic Homolog 3; MAD Protein Homolog; Mothers Against DPP Homolog 3; MAD Homolog JV15-2; MAD Homolog 3; SMAD Family Member; HMAD-3; MAD Homolog; HSMAD3; HSPC193; MAD3; SMAD 3; MAD, Mothers Against Decapentaplegic Homolog 3 (Drosophila); LDS1C; SMAD, Mothers Against DPP Homolog 3 (Drosophila); LDS3; SMAD Family Member 3; Mothers Against Decapentaplegic Homolog
Species:
Human
Source:
E. coli
5
4
4 Cited Publications
Cat. No.: HY-P80853
Synonyms: SMAD2; MADH2; MADR2; Mothers against decapentaplegic homolog 2; MAD homolog 2; Mothers against DPP homolog 2; JV18-1; MAD-related protein 2; hMAD-2; SMAD family member 2; SMAD 2; SMAD2; hSMAD2
3
Category:
Human Gut Microbiota Metabolites Microorganisms Ketones, Aldehydes, Acids Other Diseases Endogenous metabolite Disease Research Fields
Target:
3
3 Cited Publications
Cat. No.: HY-W017386
CAS No.: 3715-31-9
3
3 Cited Publications
Cat. No.: HY-P80324
Synonyms: Drosophila, homolog of, MADR2 antibody;
hMAD-2 antibody;
JV181 antibody;
MAD antibody;
MAD homolog 2 antibody;
MADH2 antibody;
MADR2 antibody;
MGC22139 antibody;
SMAD 2 antibody;
SMAD family member 2 antibody;
SMAD2 antibody
2
1
1 Cited Publications
Synonyms: ZIO 301; D 24851
Research Areas:
Indibulin (ZIO 301), an orally applicable inhibitor of tubulin assembly, shows potent anticancer activity with a minimal neurotoxicity. Indibulin reduces inter-kinetochoric tension, produces aberrant spindles, activates mitotic checkpoint proteins Mad2 and BubR1, and induces mitotic arrest and apoptosis .
1
1 Cited Publications
Cat. No.: HY-P71540
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: MAD2L1; Mitotic Arrest Deficient 2-Like Protein 1; Mitotic Arrest Deficient 2 Like 1; MAD2-Like Protein 1; MAD2; Mitotic Arrest Deficient, Yeast, Homolog-Like 1; HSMAD2; MAD2 Mitotic Arrest Deficient-Like 1; MAD2 (Mitotic Arrest Deficient, Yeast, Homolog)
Species:
Human
Source:
E. coli
1
1
1
1
1
1 Cited Publications
Cat. No.: HY-P86139
Synonyms: SMAD2; MADH2; MADR2; Mothers against decapentaplegic homolog 2; MAD homolog 2; Mothers against DPP homolog 2; JV18-1; MAD-related protein 2; hMAD-2; SMAD family member 2; SMAD 2; SMAD2; hSMAD2; SMAD3; MADH3; Mothers against decapentaplegic
Research Areas:
Br-Val-Ala-NH2-bicyclo[1.1.1]pentane-7-MAD-MDCPT (Formula V) is a agent-linker conjugate that composed of a potent topoisomerase I inhibitor and a linker to make an antibody agent conjugate (ADC), ABBV-969 .
Target:
Research Areas:
7-MAD-MDCPT, a Camptothecin analog, is a toxin payload in antibody drug conjugates (ADCs) .
Target:
Research Areas:
NH2-bicyclopentane-7-MAD-MDCPT (Formula I) is a topoisomerase I (TOP1) inhibitor. NH2-bicyclopentane-7-MAD-MDCPT is applicable to the synthesis of the ADC ABBV-969. NH2-bicyclopentane-7-MAD-MDCPT is used in research on lung adenocarcinoma and melanoma .
Cat. No.: HY-171945
CAS No.: 2850366-99-1
Synonyms: ABBV-400; Temab-A
Research Areas:
Telisotuzumab Adizutecan (ABBV-400) is an anti-c-Met antibody-drug conjugate (ADC). Telisotuzumab Adizutecan is composed of the humanized anti-c-Met antibody Telisotuzumab (HY-P99391) and the topoisomerase 1 inhibitor (7-MAD-MDCPT) (HY-132162). Telisotuzumab Adizutecan exhibits significant anti-tumor activity against advanced solid tumors such as colorectal cancer, gastric cancer, and non-small cell lung cancer .
Cat. No.: HY-164367
CAS No.: 2396667-62-0
Target:
Research Areas:
Mal-Bal-Ph(β-D-Glucose)-7-MAD-MDCPT (example 70) is an ADC drug-linker conjugate composed of the Camptothecin analog 7-MAD-MDCPT (HY-132162), and a Mal-Bal-Ph(β-D-Glucose) linker. DBCO-PEG2-C2-acid can be used to synthesize antibody-drug conjugates (ADCs) .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
