1. Antibody-drug Conjugate/ADC Related Cell Cycle/DNA Damage
  2. Drug-Linker Conjugates for ADC Topoisomerase
  3. Br-Val-Ala-NH2-bicyclo[1.1.1]pentane-7-MAD-MDCPT

Br-Val-Ala-NH2-bicyclo[1.1.1]pentane-7-MAD-MDCPT 

Cat. No.: HY-148820 Purity: 98.43%
COA Handling Instructions

Br-Val-Ala-NH2-bicyclo[1.1.1]pentane-7-MAD-MDCPT (Formula V) is a agent-linker conjugate that composed of a potent topoisomerase I inhibitor and a linker to make antibody agent conjugate (ADC).

For research use only. We do not sell to patients.

Br-Val-Ala-NH2-bicyclo[1.1.1]pentane-7-MAD-MDCPT Chemical Structure

Br-Val-Ala-NH2-bicyclo[1.1.1]pentane-7-MAD-MDCPT Chemical Structure

CAS No. : 2857037-70-6

Size Price Stock Quantity
1 mg USD 830 In-stock
5 mg USD 2050 In-stock
10 mg USD 3350 In-stock
50 mg   Get quote  
100 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

Br-Val-Ala-NH2-bicyclo[1.1.1]pentane-7-MAD-MDCPT (Formula V) is a agent-linker conjugate that composed of a potent topoisomerase I inhibitor and a linker to make antibody agent conjugate (ADC)[1].

IC50 & Target

Drug-Linker Conjugates for ADC[1]

In Vitro

Br-Val-Ala-NH2-bicyclo[1.1.1]pentane-7-MAD-MDCPT can be conjugated to an anti-c-Met antibody to form an anti-c-Met topoisomerase 1 Inhibitorsantibody drug conjugate (ADC)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

764.62

Formula

C36H38BrN5O9

CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

BrCC(N[C@@H](C(C)C)C(N[C@@H](C)C(NC12CC(C2)(C3=C4C(C(N5C4)=CC([C@](O)(C(OC6)=O)CC)=C6C5=O)=NC7=CC(OCO8)=C8C=C73)C1)=O)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (130.78 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.3078 mL 6.5392 mL 13.0784 mL
5 mM 0.2616 mL 1.3078 mL 2.6157 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.3078 mL 6.5392 mL 13.0784 mL 32.6960 mL
5 mM 0.2616 mL 1.3078 mL 2.6157 mL 6.5392 mL
10 mM 0.1308 mL 0.6539 mL 1.3078 mL 3.2696 mL
15 mM 0.0872 mL 0.4359 mL 0.8719 mL 2.1797 mL
20 mM 0.0654 mL 0.3270 mL 0.6539 mL 1.6348 mL
25 mM 0.0523 mL 0.2616 mL 0.5231 mL 1.3078 mL
30 mM 0.0436 mL 0.2180 mL 0.4359 mL 1.0899 mL
40 mM 0.0327 mL 0.1635 mL 0.3270 mL 0.8174 mL
50 mM 0.0262 mL 0.1308 mL 0.2616 mL 0.6539 mL
60 mM 0.0218 mL 0.1090 mL 0.2180 mL 0.5449 mL
80 mM 0.0163 mL 0.0817 mL 0.1635 mL 0.4087 mL
100 mM 0.0131 mL 0.0654 mL 0.1308 mL 0.3270 mL
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Br-Val-Ala-NH2-bicyclo[1.1.1]pentane-7-MAD-MDCPT Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
Br-Val-Ala-NH2-bicyclo[1.1.1]pentane-7-MAD-MDCPT
Cat. No.:
HY-148820
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