Br-Val-Ala-NH2-bicyclo[1.1.1]pentane-7-MAD-MDCPT
Based on 1 Customer Validation
Br-Val-Ala-NH2-bicyclo[1.1.1]pentane-7-MAD-MDCPT (Formula V) is a agent-linker conjugate that composed of a potent topoisomerase I inhibitor and a linker to make an antibody agent conjugate (ADC), ABBV-969.
For research use only. We do not sell to patients.
- Purity : 98.65%
- CAS No.: 2857037-70-6
- Formula: C36H38BrN5O9
- Molecular Weight:764.62
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Storage:
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
![Br-Val-Ala-NH2-bicyclo[1.1.1]pentane-7-MAD-MDCPT Chemical Structure](https://file.medchemexpress.com/product_pic/hy-148820.gif "Click to View Br-Val-Ala-NH2-bicyclo[1.1.1]pentane-7-MAD-MDCPT Chemical Structure")
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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HY-15575
VcMMAEDrug-Linker Conjugate for ADC -
![NH2-bicyclo[1.1.1]pentane-7-MAD-MDCPT](https://file.medchemexpress.com/product_pic/hy-148819.gif)
HY-148819
NH2-bicyclo[1.1.1]pentane-7-MAD-MDCPTTopoisomerase I Inhibitor -
HY-148668
MC-Gly-Gly-Phe-Gly-(R)-Cyclopropane-ExatecanDrug-Linker Conjugate for ADC -
HY-164957
Sigvotatug vedotinADC -
HY-145399
AZ14170133Drug-Linker Conjugates for ADC -
![NH2-bicyclo[1.1.1]pentane-7-MAD-MDCPT hydrochloride](https://file.medchemexpress.com/product_pic/hy-148819a.gif)
HY-148819A
NH2-bicyclo[1.1.1]pentane-7-MAD-MDCPT hydrochlorideTOP1 Inhibitor -
HY-153179
Mal-Gly-PAB-Exatecan-D-glucuronic acidADC Intermediate Compound
Biological Activity
Description
IC50 & Target
Drug-Linker Conjugates for ADC[1]
In Vitro
Br-Val-Ala-NH2-bicyclo[1.1.1]pentane-7-MAD-MDCPT can be conjugated to an anti-c-Met antibody to form an anti-c-Met topoisomerase 1 Inhibitorsantibody drug conjugate (ADC)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
Chemical Information
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CAS No. 2857037-70-6
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Appearance Solid
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Molecular Weight 764.62
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Formula C36H38BrN5O9
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Color Light yellow to yellow
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SMILES
BrCC(N[C@@H](C(C)C)C(N[C@@H](C)C(NC12CC(C2)(C3=C4C(C(N5C4)=CC([C@](O)(C(OC6)=O)CC)=C6C5=O)=NC7=CC(OCO8)=C8C=C73)C1)=O)=O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvent & Solubility
In Vitro:
DMSO : 100 mg/mL (130.78 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (275 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.3078 mL | 6.5392 mL | 13.0784 mL | 32.6960 mL |
| 5 mM | 0.2616 mL | 1.3078 mL | 2.6157 mL | 6.5392 mL | |
| 10 mM | 0.1308 mL | 0.6539 mL | 1.3078 mL | 3.2696 mL | |
| 15 mM | 0.0872 mL | 0.4359 mL | 0.8719 mL | 2.1797 mL | |
| 20 mM | 0.0654 mL | 0.3270 mL | 0.6539 mL | 1.6348 mL | |
| 25 mM | 0.0523 mL | 0.2616 mL | 0.5231 mL | 1.3078 mL | |
| 30 mM | 0.0436 mL | 0.2180 mL | 0.4359 mL | 1.0899 mL | |
| 40 mM | 0.0327 mL | 0.1635 mL | 0.3270 mL | 0.8174 mL | |
| 50 mM | 0.0262 mL | 0.1308 mL | 0.2616 mL | 0.6539 mL | |
| 60 mM | 0.0218 mL | 0.1090 mL | 0.2180 mL | 0.5449 mL | |
| 80 mM | 0.0163 mL | 0.0817 mL | 0.1635 mL | 0.4087 mL | |
| 100 mM | 0.0131 mL | 0.0654 mL | 0.1308 mL | 0.3270 mL |
Br-Val-Ala-NH2-bicyclo[1.1.1]pentane-7-MAD-MDCPT Related Classifications
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