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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
13 Results for "
MC5R
" in MedChemExpress (MCE) Product Catalog:
Products (13)
13 Results for "MC5R" in MCE Product Catalog:
3
3 Cited Publications
製品番号: HY-P0227
CAS 番号: 168482-23-3
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研究分野:
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1 Cited Publications
Target:
研究分野:
THIQ is the first selective agonist of the melanocortin-4 receptor (MC4R), with high affinity and potency for hMC4R (IC50=1.2 nM, EC50=2.1 nM) and rMC4R (IC50=0.6 nM, EC50=2.9 nM). THIQ maintains low potency at MC1R, MC3R and MC5R. THIQ plays a role in eliciting erectile activity in rodents. THIQ acts as a pharmacoperone of the MC4R rescuing the cell surface expression and signaling of some intracellularly retained MC4R mutants .
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JNJ-10229570 is an antagonist of melanocortin receptor 1 (MC1R) and melanocortin receptor 5 (MC5R), which inhibits sebaceous gland differentiation and the production of sebum-specific lipids. JNJ-10229570 inhibits the binding of 125I-NDP-α-MSH to cells expressing human MC1R and MC5R, with IC50 values of 270 nM and 200 nM, respectively.
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BMS-470539 dihydrochloride is a highly potent and selective melanocortin-1 receptor (MC-1R) agonist with an IC50 of 120 nM, an EC50 of 28 nM. BMS-470539 dihydrochloride does not activate MC-3R and is a very weak partial agonist at MC-4R and MC-5R. BMS-470539 dihydrochloride has potently anti-inflammatory properties .
製品番号: HY-P10571
CAS 番号: 2445822-54-6
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製品番号: HY-RS08212
研究分野:
MC5R Human Pre-designed siRNA Set A contains three designed siRNAs for MC5R gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
製品番号: HY-RS08213
研究分野:
Mc5r Mouse Pre-designed siRNA Set A contains three designed siRNAs for Mc5r gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
製品番号: HY-RS08214
研究分野:
Mc5r Rat Pre-designed siRNA Set A contains three designed siRNAs for Mc5r gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
製品番号: HY-P11469
CAS 番号: 322639-20-3
製品番号: HY-107139R
CAS 番号: 524923-88-4
研究分野:
JNJ-10229570 (Standard) is the analytical standard of JNJ-10229570 (HY-107139). This product is intended for research and analytical applications. JNJ-10229570 is an antagonist of melanocortin receptor 1 (MC1R) and melanocortin receptor 5 (MC5R), which inhibits sebaceous gland differentiation and the production of sebum-specific lipids. JNJ-10229570 inhibits the binding of 125I-NDP-α-MSH to cells expressing human MC1R and MC5R, with IC50 values of 270 nM and 200 nM, respectively.
製品番号: HY-P11432
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研究分野:
製品番号: HY-10624R
CAS 番号: 312637-48-2
研究分野:
THIQ (Standard) is the analytical standard of THIQ (HY-10624). This product is intended for research and analytical applications. THIQ is the first selective agonist of the melanocortin-4 receptor (MC4R), with high affinity and potency for hMC4R (IC50=1.2 nM, EC50=2.1 nM) and rMC4R (IC50=0.6 nM, EC50=2.9 nM). THIQ maintains low potency at MC1R, MC3R and MC5R. THIQ plays a role in eliciting erectile activity in rodents. THIQ acts as a pharmacoperone of the MC4R rescuing the cell surface expression and signaling of some intracellularly retained MC4R mutants .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
