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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
11 Results for "
MTD
" in MedChemExpress (MCE) Product Catalog:
Products (11)
11 Results for "MTD" in MCE Product Catalog:
1
1 Cited Publications
Target:
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NF-κB-IN-11 (Compound 3i) is a NF-κB inhibitor. NF-κB-IN-11 inhibits TNF-α induced activation of NF-κB pathway, and inhibits nuclear translocation of NF-κB. NF-κB-IN-11 down-regulates the expression levels of phosphor-IKK, IκBα, and NF-κB p65. NF-κB-IN-11 has anti-inflammatory activity, and alleviates dextran sulfate sodium-induced colitis in mice. NF-κB-IN-11 (p.o.) shows a MTD more than 1852 mg/kg in mice acute toxicity assay .
Cat. No.: HY-161402
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METTL16-IN-1 is a potent METTL16 inhibitor with an IC50 value of 1.7 μM and a Kd value of 1.35 μM. Mettl16-in-1 inhibits the binding interaction of U6 snRNA deletion and METTL16 MTD with an IC50 value of 2.5 μM. METTL16-IN-1 has antitumor activity .
AG-024322 is a potent ATP-competitive pan-CDK inhibitor against cell cycle kinases CDK1, CDK2, and CDK4 with Ki values in the 1-3 nM range . AG-024322 displays broad-spectrum anti-tumor activity and clear target modulation in vivo. AG-024322 induces cell apoptosis .
Category:
Leguminosae Glycine max (L.) merr Ketones, Aldehydes, Acids Plants Disease Research Fields Cancer
Target:
Cat. No.: HY-P10762
CAS No.: 2082631-84-1
Synonyms: CBP-1008; LDC 10B
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Cat. No.: HY-P10759
CAS No.: 372491-73-1
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Cat. No.: HY-RS18323
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Bok Mouse Pre-designed siRNA Set A contains three designed siRNAs for Bok gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-P10765
CAS No.: 951792-83-9
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Cat. No.: HY-131503S
Synonyms: 13-MTD-d6; 13-Methylmyristic acid-d6
Cat. No.: HY-RS08737
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MT1E Human Pre-designed siRNA Set A contains three designed siRNAs for MT1E gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-106154
CAS No.: 274912-87-7
Research Areas:
DTS-201 (CPI-0004) is a peptidic prodrug of Doxorubicin (HY-15142A). DTS-201, comprising the tetrapeptide portion, is cleaved by endopeptidases in the tumor environment to produce metabolites that subsequently enter the cell and are converted to active Doxorubicin. DTS-201 shows antitumoral efficacy in tumor xenograft models of prostate, breast, and lung cancer .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
