26 Results for "

NPRs

" in MedChemExpress (MCE) Product Catalog:
Products (26)

26 Results for "NPRs" in MCE Product Catalog:

2
2 Cited Publications
Cat. No.: HY-P1237
CAS No.: 127869-51-6
C-Type Natriuretic Peptide (CNP) (1-22), human, a 1-22 fragment of CNP, is a natriuretic peptide receptor B (NPR-B) agonist. C-Type Natriuretic Peptide (CNP) (1-22), human inhibits cAMP synthesis stimulated by the physiological agonists histamine and 5-HT or directly by Forskolin. CNP is a potent, endothelial-derived relaxant and growthinhibitory factor .
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2
2 Cited Publications
Cat. No.: HY-P1237A
CAS No.: 1966153-17-2
C-Type Natriuretic Peptide (CNP) (1-22), human (TFA),a 1-22 fragment of CNP, is a natriuretic peptide receptor B (NPR-B) agonist. C-Type Natriuretic Peptide (CNP) (1-22), human (TFA) inhibits cAMP synthesis stimulated by the physiological agonists histamine and 5-HT or directly by Forskolin. CNP is a potent, endothelial-derived relaxant and growthinhibitory factor .
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1
1 Cited Publications
Cat. No.: HY-P10869
dCNP binds to NPR-B/C receptor, activates cGMP signaling pathway, and regulates vascular function. dCNP exhibits anti-hypoxia property through downregulation of hypoxia-related genes expressions like HIF1α and HIF2α. dCNP inhibits the induction of tumor stroma and exhibits anti-fibrosis activity. dCNP upregulates CTLs, NK cells, and conventional type 1 dendritic cells in tumors, and activates immune responses .
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Cat. No.: HY-P0003
CAS No.: 124584-08-3
Synonyms: Brain Natriuretic Peptide-32 human; BNP-32
Nesiritide (Brain Natriuretic Peptide-32 human) is a recombinant human B-type natriuretic peptide. Nesiritide is a NPRs agonist, with Kd values of 7.3 and 13 pM for NPR-A and NPR-C, respectively. Nesiritide regulates V1/2 activation/inactivation of the L-type calcium channel. Nesiritide shows vasodilatory, diuretic, and natriuretic activities. Nesiritide is used in cardiovascular diseases such as heart failure and vascular remodeling after arterial injury .
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Cat. No.: HY-P3503
CAS No.: 1480724-61-5
Synonyms: BMN 111
Target:  

FGFR

Research Areas:  

Others

Vosoritide (BMN 111) is a modified recombinant CNP (C-type natriuretic peptide) analogue, binds to NPR-B (natriuretic peptide receptor type B) and reduces the activity of FGFR3 (fibroblast growth factor receptor 3). Vosoritide can be used in achondroplasia and dwarfism research .
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Cat. No.: HY-P3503A
Synonyms: BMN 111 acetate
Target:  

FGFR

Research Areas:  

Others

Vosoritide (BMN 111) acetate is a natriuretic peptide receptor 2 (NPR2) agonist that acts on the proliferation and differentiation of chondrocytes to promote bone growth .
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Cat. No.: HY-P1419
CAS No.: 124833-45-0
AP 811 is a selective atrial natriuretic peptide clearance receptor (ANP-CR, NPR3) antagonist with a Ki of 0.48 nM. AP 811 displays >20000-fold selectivity for NPR3 over NPR1. AP 811 abolishes ANP-induced pump stimulation .
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Cat. No.: HY-P990951
CAS No.: 2845128-05-2
Synonyms: REGN-5381
Vixticibart (REGN-5381) is a fully human IgG4 monoclonal antibody and NPR1 agonist that targets NPR1. Vixticibart stabilizes the receptor in an activated conformation by binding to the N-terminal domain of NPR1, and enhances the activity of endogenous ligands ANP and BNP without blocking ligand binding when these ligands are present. Vixticibart exerts vasodilatory and hypotensive effects by inducing cGMP production, preferentially dilating venous vessels to reduce systolic and venous pressure, but does not induce diuresis and may trigger a compensatory increase in heart rate. Vixticibart produces a synergistic hypotensive effect when combined with angiotensin-converting enzyme inhibitors or angiotensin receptor blockers, and is currently mainly used in research related to heart failure and hypertension .
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Cat. No.: HY-P1526
CAS No.: 111863-73-1
ANP [Des18-22] 4-23 amide rat is a polypeptide fragment of rat atrial natriuretic peptide (ANP) that specifically binds NPR-C .
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Cat. No.: HY-153650
CAS No.: 1394592-04-1
Purity:  99.22%
Research Areas:  

Others

JS11 is an inhibitor for natriuretic polypeptide receptor 1 (Npr1) with an IC50 of 1.9 μM for hNpr1. JS11 ameliorates the pruritus in mouse models .
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Cat. No.: HY-143316
CAS No.: 2768328-61-4
Purity:  99.30%
Target:  

Guanylate Cyclase

Research Areas:  

Neurological Disease

NPR-C activator 1 (Compound 1) is a potent activator of natriuretic peptide receptor C (NPR-C). C-type natriuretic peptide (CNP) is involved in the regulation of vascular homeostasis. NPR-C activator 1 is identified as a potent agonist (EC50 ∼ 1 μM) with promising in vivo pharmacokinetic properties .
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Cat. No.: HY-RS09498
Research Areas:  

Others

NPR2 Human Pre-designed siRNA Set A contains three designed siRNAs for NPR2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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Cat. No.: HY-177062
CAS No.: 3055143-61-5
NPRA agonist-11 (Example 161) is an NPRA (NPR1) agonist, with AC50 values of 1.681 μM and 0.989 μM for humans and monkeys, respectively. NPRA agonist-11 can be used in the research of cardiovascular diseases and other disorders .
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Cat. No.: HY-P0003A
CAS No.: 1684439-46-0
Synonyms: Brain Natriuretic Peptide-32 human acetate; BNP-32 acetate
Nesiritide (Brain Natriuretic Peptide-32 human) acetate is a recombinant human B-type natriuretic peptide. Nesiritide acetate is a NPRs agonist, with Kd values of 7.3 and 13 pM for NPR-A and NPR-C, respectively. Nesiritide acetate regulates V1/2 activation/inactivation of the L-type calcium channel. Nesiritide acetate shows vasodilatory, diuretic, and natriuretic activities. Nesiritide acetate is used in cardiovascular diseases such as heart failure and vascular remodeling after arterial injury .
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Cat. No.: HY-P1419A
Target:  

Endothelin Receptor

Research Areas:  

Cardiovascular Disease

AP 811 acetate is a selective atrial natriuretic peptide clearance receptor (ANP-CR, NPR3) antagonist with a Ki of 0.48 nM. AP 811 acetate displays >20000-fold selectivity for NPR3 over NPR1. AP 811 acetate abolishes ANP-induced pump stimulation .
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Cat. No.: HY-RS09497
Research Areas:  

Others

NPR1 Human Pre-designed siRNA Set A contains three designed siRNAs for NPR1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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Cat. No.: HY-RS09499
Research Areas:  

Others

NPR3 Human Pre-designed siRNA Set A contains three designed siRNAs for NPR3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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Cat. No.: HY-RS19149
Research Areas:  

Others

Npr3 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Npr3 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

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Cat. No.: HY-RS21394
Research Areas:  

Others

Npr2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Npr2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

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Cat. No.: HY-RS25113
Research Areas:  

Others

Npr1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Npr1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

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