1 Result for "

NSC324645

" in MedChemExpress (MCE) Product Catalog:
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1 Results for "NSC324645" in MCE Product Catalog:

Marcfortine A
Marcfortine A
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Cat. No.: HY-126638
CAS No.: 75731-43-0
Synonyms: NSC 324645
Category:  

Human Gut Microbiota Metabolites Microorganisms Endogenous metabolite

Target:  

Parasite

Marcfortine A is an indole alkaloid originally isolated from P. roqueforti. It has nematocidal activity against the parasitic nematode H. contortus (LD99=0.06 μg/mL) and inhibits motility of adult worms (EC50=2 μM). Marcfortine A eliminates H. contortus, T. colubriformis, and O. ostertagi from experimentally infected jirds (ED95s=0.33, 0.11, and 2.5 mg/animal, respectively). It dose-dependently inhibits nicotine-induced calcium mobilization in SH-SY5Y and TE-671 cells expressing α3 subunit-containing human nicotinic acetylcholine receptors (nAChRs) and muscle-type nAChRs, respectively.
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