1855 Results for "

Natural Product

" in MedChemExpress (MCE) Product Catalog:
Products (1855)

1855 Results for "Natural Product" in MCE Product Catalog:

27
Epoxomicin
Epoxomicin
0 Images
27 Publications Verification
Cat. No.: HY-13821
CAS No.: 134381-21-8
Purity:  99.39%
Synonyms: BU-4061T
Category:  

Microorganisms Ketones, Aldehydes, Acids Disease Research Fields Inflammation/Immunology

Target:  

Proteasome Apoptosis

Epoxomicin (BU-4061T) is an epoxyketone-containing natural product and a potent, selective and irreversible proteasome inhibitor. Epoxomicin covalently binds to the LMP7, X, MECL1, and Z catalytic subunits of the proteasome and potently inhibits primarily the chymotrypsin-like activity. Epoxomicin can cross the blood-brain barrier. Epoxomicin has strongly antitumor and anti-inflammatory activity .
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24
Basement Membrane Matrix
Basement Membrane Matrix
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24 Cited Publications
Cat. No.: HY-K6002

MCE Basement Membrane Matrix is primarily composed of natural basement membrane matrix extracted from mouse tumors.This product is mainly used for studies of tumor invasion, angiogenesis and organoids culture while avoiding color interference in subsequent experiments.

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23
Rottlerin
Rottlerin
0 Images
23 Cited Publications
Cat. No.: HY-18980
CAS No.: 82-08-6
Synonyms: Mallotoxin; NSC 56346; NSC 94525
Category:  

Flavonoids Chalcones Phenols Polyphenols Euphorbiaceae Plants Disease Research Fields Cancer Mallotus philippensis

Target:  

PKC Autophagy Apoptosis HIV RABV

Rottlerin, a natural product purified from Mallotus Philippinensis, is a specific PKC inhibitor, with IC50 values for PKCδ of 3-6 μM, PKCα,β,γ of 30-42 μM, PKCε,η,ζ of 80-100 μM. Rottlerin acts as a direct mitochondrial uncoupler, and stimulates autophagy by targeting a signaling cascade upstream of mTORC1. Rottlerin induces apoptosis via caspase 3 activation . Rottlerin inhibits HIV-1 integration and Rabies virus (RABV) infection .
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21
Basement Membrane Matrix (Phenol Red)
Basement Membrane Matrix (Phenol Red)
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21 Cited Publications
Cat. No.: HY-K6001

MCE Basement Membrane Matrix (Phenol Red) is primarily composed of a natural basement membrane matrix derived from mouse tumors. This product is mainly for studies of tumor invasion, angiogenesis, and organoid culture.

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17
Crocin
Crocin
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17 Cited Publications
Cat. No.: HY-N0697
CAS No.: 42553-65-1
Synonyms: Crocin I
Category:  

Neurological Disease Anti-aging Lridaceae Plants Crocus sativus L. Functional Molecules Terpenoids Research of Health Products Diterpenoids Disease Research Fields Inflammation/Immunology Cancer

Target:  

Endogenous Metabolite JAK Apoptosis

Crocin (Crocin I) is an orally active natural product that can be isolated from the stigma of Crocus sativus. Crocin inhibits tumor cell proliferation and promotes apoptosis through JAK pathway. Crocin has anti-inflammatory, antioxidant and antitumor activities .
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15
Hydroxysafflor yellow A
Hydroxysafflor yellow A
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15 Cited Publications
Cat. No.: HY-N0567
CAS No.: 78281-02-4
Synonyms: Safflomin A; HSYA
Category:  

Flavonoids Chalcones Monophenols Carthamus tinctorius L. Phenols Plants Compositae Disease Research Fields Cancer

Target:  

Apoptosis Autophagy

Hydroxysafflor yellow A (Safflomin A) is a natural product of flavonoids isolated from safflower. Hydroxysafflor yellow A can inhibit cell proliferation and promote apoptosis through the autophagy pathway. Hydroxysafflor yellow A has anti-inflammatory, antioxidant and antitumor effects. Hydroxysafflor yellow A can be used in the study of cardiovascular disease .
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15
Thymoquinone
Thymoquinone
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15 Cited Publications
Cat. No.: HY-D0803
CAS No.: 490-91-5
Category:  

Quinones Nigella sativa L. Ranunculaceae Benzene Quinones Plants Disease Research Fields Inflammation/Immunology

Target:  

Apoptosis VEGFR PI3K Akt

Thymoquinone is an orally active natural product isolated from N. sativa Thymoquinone down-regulates the VEGFR2-PI3K-Akt pathway. Thymoquinone has antioxidant, anti-inflammatory, anticancer, antiviral, anticonvulsant, antifungal, antiviral, antiangiogenic activity and hepatoprotective effects. Thymoquinone can be used to study Alzheimer's disease, cancer, cardiovascular disease, infectious disease and inflammation .
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14
Cepharanthine
Cepharanthine
0 Images
14 Cited Publications
Cat. No.: HY-N6972
CAS No.: 481-49-2
Category:  

Infection Alkaloids Stephania cepharantha Hayata Plants Disease Research Fields Isoquinoline Alkaloids Inflammation/Immunology Menispermaceae Stephania japonica (Thunb.) Miers

Target:  

Autophagy SARS-CoV Cytochrome P450 Apoptosis Parasite

Cepharanthine is a natural product that can be isolated from the plant Stephania cephalantha Hayata. Cepharanthine has anti-severe acute respiratory syndrome coronavirus 2 (anti-SARS-CoV-2) activities. Cepharanthine has good effective in suppressing viral proliferation (half maximal (50%) inhibitory concentration (IC50) and 90% inhibitory concentration (IC90) values of 1.90 and 4.46 μM . Cepharanthine can also effectively reverses P-gp-mediated multidrug resistance in K562 cells and increase enhances the sensitivity of anticancer agents in xenograft mice model . Cepharanthine shows inhibitory effects of human liver cytochrome P450 enzymes CYP3A4, CYP2E1 and CYP2C9. Cepharanthine has antitumor, anti-inflammatory and antinociceptive effects .
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14
Sodium citrate dihydrate
Sodium citrate dihydrate
0 Images
14 Cited Publications
Cat. No.: HY-B1610
CAS No.: 6132-04-3
Synonyms: Trisodium citrate dihydrate; Citric acid trisodium salt dihydrate
Category:  

Cardiovascular Disease Ketones, Aldehydes, Acids Endogenous metabolite Disease Research Fields

Target:  

Apoptosis Bacterial

Sodium citrate (Trisodium citrate) dihydrate is an orally active natural product that can be found in citrus fruits. Sodium citrate dehydrate can inhibit the proliferation of tumor cells and induce apoptosis. Sodium citrate dehydrate has antibacterial, anti-tumor and antioxidant activities. Sodium citrate dehydrate can be prepared as a cosolvent or buffer .
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13
Sodium citrate dihydrate, for molecular biology
Sodium citrate dihydrate, for molecular biology
0 Images
13 Cited Publications
Cat. No.: HY-B1610I
CAS No.: 6132-04-3
Synonyms: Trisodium citrate dihydrate, for molecular biology
Sodium citrate (Trisodium citrate) dihydrate, for molecular biology is an orally active natural product that can be found in citrus fruits. Sodium citrate dihydrate can inhibit the proliferation of tumor cells and induce apoptosis. Sodium citrate dihydrate has antibacterial, anti-tumor and antioxidant activities. Sodium citrate dihydrate can be prepared as a cosolvent or buffer .
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13
Sodium citrate dihydrate, meets USP testing specifications
Sodium citrate dihydrate, meets USP testing specifications
0 Images
13 Cited Publications
Cat. No.: HY-B1610E
CAS No.: 6132-04-3
Synonyms: Trisodium citrate dihydrate, meets USP testing specifications
Sodium citrate (Trisodium citrate) dihydrate, meets USP testing specifications is an orally active natural product that can be found in citrus fruits. Sodium citrate dihydrate can inhibit the proliferation of tumor cells and induce apoptosis. Sodium citrate dihydrate has antibacterial, anti-tumor and antioxidant activities. Sodium citrate dihydrate can be prepared as a cosolvent or buffer .
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11
Dioscin
Dioscin
0 Images
11 Cited Publications
Cat. No.: HY-N0124
CAS No.: 19057-60-4
Synonyms: Collettiside III; CCRIS 4123
Category:  

other families Plants Disease Research Fields Cancer Steroids

Target:  

Autophagy Apoptosis

Dioscin (CCRIS 4123; Collettiside III) is a natural plant-derived steroidal saponin that has good anti-cancer activity against a variety of cancer cells. Dioscin causes DNA damage and induces apoptosis in HeLa and SiHa cells. Dioscin regulates ROS-mediated DNA damage and mitochondrial signaling pathways, exerting anticancer activity .
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7
Isoacteoside
Isoacteoside
0 Images
7 Cited Publications
Cat. No.: HY-N0022
CAS No.: 61303-13-7
Synonyms: Isoverbascoside
Category:  

Simple Phenylpropanols Cistanche deserticola Ma Metabolic Disease Orobanchaceae Phenols Polyphenols Phenylpropanoids Plants Disease Research Fields

Target:  

Apoptosis Reactive Oxygen Species (ROS) Akt mTOR PI3K NO Synthase COX p38 MAPK Toll-like Receptor (TLR) Amyloid-β

Isoacteoside is a natural product that can significantly inhibit the formation of glycation end products. Isoacteoside regulates the AKT/PI3K/m-TOR/NF-κB signaling pathway, induces apoptosis in OVCAR-3 cell. Isoacteoside exhibits antitumor, anti-inflammatory, anti-obesity and neuroprotective activities .
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7
(R)-(-)-Gossypol acetic acid
(R)-(-)-Gossypol acetic acid
0 Images
7 Cited Publications
Cat. No.: HY-15464A
CAS No.: 866541-93-7
Purity:  98.93%
Synonyms: AT-101 (acetic acid); (-)-Gossypol acetic acid; (R)-Gossypol acetic acid
Target:  

Bcl-2 Family Autophagy

Research Areas:  

Cancer

(R)-(-)-Gossypol acetic acid (AT-101 (acetic acid)) is the levorotatory isomer of a natural product Gossypol. AT-101 is determined to bind to Bcl-2, Mcl-1 and Bcl-xL proteins with Kis of 260±30 nM, 170±10 nM, and 480±40 nM, respectively.
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5
Glycodeoxycholic acid
Glycodeoxycholic acid
0 Images
5 Cited Publications
Cat. No.: HY-125731
CAS No.: 360-65-6
Purity:  99.08%
Category:  

Metabolic Disease Endogenous metabolite Disease Research Fields Steroids

Target:  

Endogenous Metabolite STAT Autophagy

Glycodeoxycholic Acid is a natural product found in Streptomyces nigricans, Trypanosoma brucei and C. elegans. Glycodeoxycholic Acid induces hepatocyte necrosis and autophagy in patients with obstructive cholestasis .
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5
(S)-Gossypol (acetic acid)
(S)-Gossypol (acetic acid)
0 Images
5 Cited Publications
Cat. No.: HY-15464D
CAS No.: 1189561-66-7
Purity:  98.39%
Synonyms: (S)-(+)-Gossypol acetic acid
Target:  

Bcl-2 Family

Research Areas:  

Cancer

(S)-Gossypol is the isomer of a natural product Gossypol. (S)-Gossypol binds to the BH3-binding groove of Bcl-xL and Bcl-2 proteins with high affinity.
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5
Peimine
Peimine
0 Images
5 Cited Publications
Cat. No.: HY-N0212
CAS No.: 23496-41-5
Synonyms: Verticine; Dihydroisoimperialine
Category:  

Alkaloids Piperidine Alkaloids Liliaceae Fritillaria thunbergii Miq. Plants Disease Research Fields Inflammation/Immunology

Target:  

Apoptosis Interleukin Related TNF Receptor p38 MAPK NF-κB

Peimine (Verticine; Dihydroisoimperialine) is an orally active natural product. Peimine has anti-inflammatory, analgesic and cough relieving effects. Peimine can be used in cancer and inflammation related research .
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5
Umbelliferone
Umbelliferone
0 Images
5 Cited Publications
Cat. No.: HY-N0573
CAS No.: 93-35-6
Synonyms: 7-Hydroxycoumarin; Hydrangin; NSC 19790
Category:  

Monophenols Coumarins Phenols Phenylpropanoids Endogenous metabolite Disease Research Fields Cancer

Target:  

Apoptosis Fluorescent Dye

Umbelliferone (7-Hydroxycoumarin), a natural orally active product of the coumarin family, is a fluorescing compound which can be used as a sunscreen agent. Umbelliferone induces cell cycle arrest, apoptosis and DNA fragmentation in HepG2 cells. Umbelliferone exhibits significant anticancer effects. Umbelliferone attenuates the alteration characteristics of allergic airway inflammation. Umbelliferone displays the neuroprotective effects and cross the blood-brain barrier. Umbelliferone exhibits anti-inflammatory and antioxidant effects in chronic alcohol-fed rats .
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4
Danthron
Danthron
0 Images
4 Cited Publications
Cat. No.: HY-B0923
CAS No.: 117-10-2
Synonyms: Dantron; Chrysazin; 1,8-Dihydroxyanthraquinone
Category:  

Quinones Labiatae Anthraquinones Samanea saman (Jacq.) Merr. Phenols Polyphenols Plants Disease Research Fields Cancer

Target:  

AMPK Autophagy Bacterial Virus Protease

Danthron is a natural product extracted from the traditional Chinese medicine Salvia miltiorrhiza Bunge. Danthron functions in regulating glucose and lipid metabolism by activating AMPK.
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4
Triptonide
Triptonide
0 Images
4 Cited Publications
Cat. No.: HY-32736
CAS No.: 38647-11-9
Synonyms: NSC 165677; PG 492
Category:  

Terpenoids Celastraceae Diterpenoids Plants Tripterygium wilfordii Hook. f. Disease Research Fields Inflammation/Immunology

Target:  

Wnt β-catenin Apoptosis Autophagy

Triptonide (NSC 165677) is a natural product identified in Tripterygium wilfordii Hook F.. Triptonide is a Wnt signaling inhibitor with an IC50 of appropriately 0.3 nM. Triptonide has immunosuppression, anti-inflammatory, anti-fertility, neuroprotective and anti-lymphoma effects .
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