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Results for "

OGA

" in MedChemExpress (MCE) Product Catalog:

15

Inhibitors & Agonists

1

Recombinant Proteins

1

Antibodies

3

Oligonucleotides

Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-12588
    Thiamet G
    45+ Cited Publications

    		 OGA Autophagy Cancer
    Thiamet G is a potent and selective inhibitor of O-GlcNAcase (OGA), which acts to remove O-GlcNAc from modified proteins, with Ki of 20 nM for human OGA.
    Thiamet G
  • HY-130121
    MK-8719

    		OGA Neurological Disease
    MK-8719 is a highly potent and selective O-GlcNAcase (OGA) inhibitor (Ki=7.9 nM for hOGA) with excellent CNS penetration .
    MK-8719
  • HY-144681
    Ceperognastat

    LY3372689

    		 OGA Tau Protein Neurological Disease
    Ceperognastat (LY3372689) is an orally active O-GlcNAcase (OGA) enzyme inhibitor. Ceperognastat can be used for tauopathies research, including Alzheimer’s disease .
    Ceperognastat
  • HY-156586
    Egalognastat

    ASN90

    		 OGA Tau Protein Neurological Disease
    Egalognastat (ASN90) is a selective, brain-penetrant and orally active O-GlcNAcase (OGA) enzyme inhibitor with an IC50 value of 10.2 nM. Egalognastat increases O-GlcNAcylation of intracellular proteins like tau and α-synuclein, preventing their aggregation and toxicity. Egalognastat does not inhibit hexosaminidase (Hex). Egalognastat can be used for the research of neurodegenerative diseases, such as tauopathies and α-synucleinopathies (e.g., Alzheimer’s disease and Parkinson’s disease) .
    Egalognastat
  • HY-149552
    Ac4-5SGlcNAc

    		OGT Cancer
    Ac4-5SGlcNAc is an O-GlcNAc transferase (OGT) inhibitor. Ac4-5SGlcNAc converts intracellularly to UDP-5SGlcNAc, which competes with native UDP-GlcNAc (HY-148596) to block OGT catalytic activity, reduces cellular UDP-GlcNAc pools, and limits global protein O-GlcNAcylation. Ac4-5SGlcNAc reduces OGA levels via feedback, alters lectin signal intensities and glycan-related band masses. Ac4-5SGlcNAc can be used for the research of breast cancer .
    Ac4-5SGlcNAc
  • HY-131979
    TP-040

    O-GlcNAcase-IN-1

    		 OGA Neurological Disease
    TP-040 (O-GlcNAcase-IN-1), a chemical probe, is a potent and novel OGA inhibitor with an IC50 value of 46 nM.
    TP-040
  • HY-176852
    O-GlcNAcase-IN-3

    		OGA Neurological Disease
    O-GlcNAcase-IN-3 (Compound I) is an OGA inhibitor. O-GlcNAcase-IN-3 can be used for Alzheimer's Disease (AD) research .
    O-GlcNAcase-IN-3
  • HY-RS09757
    OGA Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    OGA Human Pre-designed siRNA Set A contains three designed siRNAs for OGA gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    OGA Human Pre-designed siRNA Set A
    OGA Human Pre-designed siRNA Set A
  • HY-RS23110
    Oga Rat Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Oga Rat Pre-designed siRNA Set A contains three designed siRNAs for Oga gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Oga Rat Pre-designed siRNA Set A
    Oga Rat Pre-designed siRNA Set A
  • HY-148240
    JNJ-65355394

    		OGA Neurological Disease
    JNJ-65355394 (Compound 28), a chemical probe, is an O-GlcNAc hydrolase (OGA) inhibitor .
    JNJ-65355394
  • HY-144681A
    rel-Ceperognastat

    rel-LY3372689

    		 OGA Tau Protein Neurological Disease
    rel-Ceperognastat (rel-LY3372689) (Compound Formula Ic) is a O-GlcNAcase (OGA) inhibitor that can be used to study the neurodegenerative diseases and disorders, such as Alzheimer's disease .
    rel-Ceperognastat
  • HY-161953
    O-GlcNAcase-IN-2

    		OGA Neurological Disease
    O-GlcNAcase-IN-2 (compound 81) is an orally effective, blood-brain barrier-permeable OGA inhibitor (IC50=4.93 nM). O-GlcNAcase-IN-2 can increase the O-GlcNAcylation level of proteins and phosphorylation of tau (p-Ser199, p-Thr205 and p-Ser396) in the OA-damaged SH-SY5Y cell model. O-GlcNAcase-IN-2 can also improve cognitive impairment in APP/PS1 mice and has potential anti-Alzheimer's disease (AD) effects .
    O-GlcNAcase-IN-2
  • HY-RS16675
    Oga Mouse Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Oga Mouse Pre-designed siRNA Set A contains three designed siRNAs for Oga gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Oga Mouse Pre-designed siRNA Set A
    Oga Mouse Pre-designed siRNA Set A
  • HY-183557
    O-GlcNAcase-IN-6

    		OGA Neurological Disease
    O-GlcNAcase-IN-6 is an orally active, blood-brain barrier-permeable O-GlcNAcase (OGA) inhibitor with an IC50 of 5.4 nM. O-GlcNAcase-IN-6 inhibits OGA activity, thereby increasing the level of O-GlcNAc glycosylation in brain tissues. O-GlcNAcase-IN-6 can be used for the research of Alzheimer's disease .
    O-GlcNAcase-IN-6
  • HY-E71360
    O-GlcNAcase, Clostridium perfringens

    		Glycosidase Others
    O-GlcNAcase, Clostridium perfringens is a glycosidase derived from Clostridium perfringens, which functions in bacterial nutrient metabolism, host interaction and virulence regulation. O-GlcNAcase is a core enzyme in the cellular signal regulatory network and serves as a key target for various major and chronic diseases. O-GlcNAcase, Clostridium perfringens can be used for basic research and drug development of O-GlcNAcase due to its high conservation in catalytic mechanism and structure with human-derived enzymes .
    O-GlcNAcase, Clostridium perfringens

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