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P. acnes

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By Targets:	Bacterial (12) Cytochrome P450 (2) Endogenous Metabolite (8) Environmental Pollutants (1) Fungal (1) Isotope-Labeled Compounds (4) Lipoxygenase (1) Reference Standards (1)
By Research Areas:	Cancer (2) Cardiovascular Disease (1) Infection (10) Inflammation/Immunology (2) Metabolic Disease (1)

Inhibitors & Agonists

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-Y0366

Lauric acid 5+ Cited Publications	Environmental Pollutants Endogenous Metabolite Bacterial	Infection
Lauric acid is a middle chain-free fatty acid with strong bactericidal properties. The EC₅₀s for P. acnes, S.aureus, S. epidermidis, are 2, 6, 4 μg/mL, respectively .

HY-Y0366S

Lauric acid-13C	Endogenous Metabolite Bacterial	Infection
Lauric acid- ¹³C is the ¹³C labeled Lauric acid. Lauric acid is a middle chain-free fatty acid with strong bactericidal properties. The EC50s for P. acnes, S.aureus, S. epidermidis, are 2, 6, 4 μg/mL, respectively.

HY-Y0366R

Lauric acid (Standard) 5+ Cited Publications	Reference Standards Endogenous Metabolite Bacterial	Infection
Lauric acid (Standard) is the analytical standard of Lauric acid. This product is intended for research and analytical applications. Lauric acid is a middle chain-free fatty acid with strong bactericidal properties. The EC₅₀s for P. acnes, S.aureus, S. epidermidis, are 2, 6, 4 μg/mL, respectively.

HY-10979

AN0128	Bacterial	Infection Inflammation/Immunology
AN0128 is a boron-containing antibacterial and anti-inflammatory agent. AN0128 against *S. aureus, S. epidermidis, P. acnes, B. subtilis* with minimum inhibitory concentration (MIC) values of 1, 0.5, 0.3, 1 μg/mL. AN0128 can be used for the research of periodontal disease and cutaneous diseases .

HY-14802

Talarozole (R enantiomer) (R)-Talarozole	Cytochrome P450	Cancer
Talarozole R enantiomer is a potent and selective inhibitor of cytochrome P450 26-mediated breakdown of endogenous all-trans retinoic acid for the treatment of psoriasis and acne.

HY-Y0366S3

Lauric acid-d3	Isotope-Labeled Compounds Endogenous Metabolite Bacterial	Infection
Lauric acid-d₃3 is the deuterium labeled Lauric acid. Lauric acid is a middle chain-free fatty acid with strong bactericidal properties. The EC50s for P. acnes, S.aureus, S. epidermidis, are 2, 6, 4 μg/mL, respectively.

HY-Y0366S1

Lauric acid-d23	Endogenous Metabolite Bacterial	Infection
Lauric acid-d₂₃3 is the deuterium labeled Lauric acid. Lauric acid is a middle chain-free fatty acid with strong bactericidal properties. The EC50s for P. acnes, S.aureus, S. epidermidis, are 2, 6, 4 μg/mL, respectively.

HY-N11546

Sapindoside B	Cytochrome P450 Bacterial Fungal	Infection Cancer
Sapindoside B is a substance with hepatoprotective activity, and also acts as a cytochrome P-450 (cytochrome P-450) inhibitor, antibacterial agent and membrane-disrupting agent. Sapindoside B reversibly inhibits the content of cytochrome P-450 in liver microsomes, suppresses the phenobarbital-induced increase in enzyme content, reduces the production of active metabolites mediated by cytochrome P-450, and alleviates hepatotoxic injury. Sapindoside B binds to Cutibacterium acnes lipase, reduces lipase activity, inhibits biofilm formation, and decreases bacterial adhesion. Sapindoside B exhibits cytotoxicity against human cancer, liver cancer, leukemia and glioblastoma cells. Sapindoside B inhibits mycelial growth of phytopathogenic fungal strains, possesses antibacterial activity against dermatophytes, and also has hemolytic/membrane-lytic activity. Sapindoside B can be used in research related to liver injury, Cutibacterium acnes biofilm-associated infections, gastric cancer, carcinoma, promyelocytic leukemia, glioblastoma, apple scab and grape gray mold .

HY-130675

(±)15-HEPE (±)15-hydroxyeicosapentaenoic acid; 15-OHEPA	Lipoxygenase Bacterial	Metabolic Disease
(±)15-HEPE is a racemic mixture of the monohydroxy fatty acids 15(R)-HEPE and 15(S)-HEPE (HY-130675A). (±)15-HEPE is active against P. acnes and S. aureus (MICs = 128 and 512 mg/L, respectively). It inhibits aggregation of isolated rat neutrophils induced by the formyl peptide receptor agonist fMLP (IC50 = 4.7 µM). Bronchoalveolar lavage fluid (BALF) levels of (±)15-HEPE are increased in patients with allergic asthma or COVID-19.

HY-123156

SC-23110	Bacterial	Infection
SC-23110 is a potent anti-acne agent. SC-23110 inhibits the growth of P. acnes, one of the organisms associated with acne, and most frequently mentioned as the organism involved in the pathogenesis of inflammatory pustules/lesions .

HY-122941

Viscidulin II	Others	Inflammation/Immunology
Viscidulin II (FL6) is a flavone. Viscidulin II can be isolated from the root of Scutellaria baicalensis. Viscidulin II significantly suppresses P. acnes-induced IL-8 and IL-1β production in THP-1 cells .

HY-Y0366S2

Lauric acid-d2	Isotope-Labeled Compounds Endogenous Metabolite Bacterial	Infection
Lauric acid-d₂ is the deuterium labeled Lauric acid. Lauric acid is a middle chain-free fatty acid with strong bactericidal properties. The EC50s for P. acnes, S.aureus, S. epidermidis, are 2, 6, 4 μg/mL, respectively.

HY-Y0366S5

Lauric acid-d5	Isotope-Labeled Compounds Endogenous Metabolite Bacterial	Infection
Lauric acid-d₅ is the deuterium labeled Lauric acid. Lauric acid is a middle chain-free fatty acid with strong bactericidal properties. The EC50s for P. acnes, S.aureus, S. epidermidis, are 2, 6, 4 μg/mL, respectively.

HY-Y0366S4

Lauric acid-13C-1	Isotope-Labeled Compounds Endogenous Metabolite Bacterial	Cardiovascular Disease
Lauric acid- ¹³C-1 is the deuterium labeled Lauric acid. Lauric acid is a middle chain-free fatty acid with strong bactericidal properties. The EC₅₀s for P. acnes, S.aureus, S. epidermidis, are 2, 6, 4 μg/mL, respectively .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-Y0366

Lauric acid 5+ Cited Publications	Infection Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Endogenous metabolite Disease Research Fields Source Classification	Environmental Pollutants Endogenous Metabolite Bacterial
Lauric acid is a middle chain-free fatty acid with strong bactericidal properties. The EC₅₀s for P. acnes, S.aureus, S. epidermidis, are 2, 6, 4 μg/mL, respectively .

HY-Y0366R

Lauric acid (Standard) 5+ Cited Publications	Infection Classification of Application Fields Ketones, Aldehydes, Acids Endogenous metabolite Disease Research Fields Source Classification	Reference Standards Endogenous Metabolite Bacterial
Lauric acid (Standard) is the analytical standard of Lauric acid. This product is intended for research and analytical applications. Lauric acid is a middle chain-free fatty acid with strong bactericidal properties. The EC₅₀s for P. acnes, S.aureus, S. epidermidis, are 2, 6, 4 μg/mL, respectively.

HY-N11546

Sapindoside B	Structural Classification Eleutherococcus sieboldianus Makino Terpenoids Diterpenoids Plants Araliaceae Source Classification	Cytochrome P450 Bacterial Fungal
Sapindoside B is a substance with hepatoprotective activity, and also acts as a cytochrome P-450 (cytochrome P-450) inhibitor, antibacterial agent and membrane-disrupting agent. Sapindoside B reversibly inhibits the content of cytochrome P-450 in liver microsomes, suppresses the phenobarbital-induced increase in enzyme content, reduces the production of active metabolites mediated by cytochrome P-450, and alleviates hepatotoxic injury. Sapindoside B binds to Cutibacterium acnes lipase, reduces lipase activity, inhibits biofilm formation, and decreases bacterial adhesion. Sapindoside B exhibits cytotoxicity against human cancer, liver cancer, leukemia and glioblastoma cells. Sapindoside B inhibits mycelial growth of phytopathogenic fungal strains, possesses antibacterial activity against dermatophytes, and also has hemolytic/membrane-lytic activity. Sapindoside B can be used in research related to liver injury, Cutibacterium acnes biofilm-associated infections, gastric cancer, carcinoma, promyelocytic leukemia, glioblastoma, apple scab and grape gray mold .

HY-122941

Viscidulin II	Structural Classification Flavonoids Flavones Labiatae Plants Medicago truncatula Gaertn. Source Classification	Others
Viscidulin II (FL6) is a flavone. Viscidulin II can be isolated from the root of Scutellaria baicalensis. Viscidulin II significantly suppresses P. acnes-induced IL-8 and IL-1β production in THP-1 cells .

Cat. No.	Product Name	Chemical Structure

HY-Y0366S

Lauric acid-13C
Lauric acid- ¹³C is the ¹³C labeled Lauric acid. Lauric acid is a middle chain-free fatty acid with strong bactericidal properties. The EC50s for P. acnes, S.aureus, S. epidermidis, are 2, 6, 4 μg/mL, respectively.

HY-Y0366S3

Lauric acid-d3
Lauric acid-d₃3 is the deuterium labeled Lauric acid. Lauric acid is a middle chain-free fatty acid with strong bactericidal properties. The EC50s for P. acnes, S.aureus, S. epidermidis, are 2, 6, 4 μg/mL, respectively.

HY-Y0366S1

Lauric acid-d23
Lauric acid-d₂₃3 is the deuterium labeled Lauric acid. Lauric acid is a middle chain-free fatty acid with strong bactericidal properties. The EC50s for P. acnes, S.aureus, S. epidermidis, are 2, 6, 4 μg/mL, respectively.

HY-Y0366S2

Lauric acid-d2
Lauric acid-d₂ is the deuterium labeled Lauric acid. Lauric acid is a middle chain-free fatty acid with strong bactericidal properties. The EC50s for P. acnes, S.aureus, S. epidermidis, are 2, 6, 4 μg/mL, respectively.

HY-Y0366S5

Lauric acid-d5
Lauric acid-d₅ is the deuterium labeled Lauric acid. Lauric acid is a middle chain-free fatty acid with strong bactericidal properties. The EC50s for P. acnes, S.aureus, S. epidermidis, are 2, 6, 4 μg/mL, respectively.

HY-Y0366S4

Lauric acid-13C-1
Lauric acid- ¹³C-1 is the deuterium labeled Lauric acid. Lauric acid is a middle chain-free fatty acid with strong bactericidal properties. The EC₅₀s for P. acnes, S.aureus, S. epidermidis, are 2, 6, 4 μg/mL, respectively .

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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P. acnes

Inhibitors & Agonists

NaturalProducts

Isotope-Labeled Compounds

Natural
Products