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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
62 Results for "
PAR2
" in MedChemExpress (MCE) Product Catalog:
Products (62)
62 Results for "PAR2" in MCE Product Catalog:
26
Research Areas:
Trypsin is a serine protease enzyme, and hydrolyzes proteins at the carboxyl side of the Lysine or Arginine. Trypsin activates PAR2 and PAR4. Trypsin induces cell-to-cell membrane fusion in PDCoV infection by the interaction of S glycoprotein of PDCoV and pAPN. Trypsin also promotes cell proliferation and differentiation. Trypsin can be used in the research of wound healing and neurogenic inflammation [2] .
14
14 Cited Publications
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AZ3451 is a potent protease-activated receptor-2 (PAR2) antagonist with IC50 of 23 nM.
14
Bafetinib is an orally active Lyn/Bcr-Abl tyrosine kinase inhibitor. Bafetinib enhances the activity of several pro-apoptotic Bcl-2 homology (BH) 3-pure proteins (Bim, Bad, Bmf, and Bik) through intrinsic apoptotic pathways regulated by the Bcl-2 family, and induces apoptosis of Ph + leukemia cells. Bafetinib has antitumor activity [2] .
6
6 Cited Publications
Cat. No.: HY-P1260
CAS No.: 245329-02-6
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6
6 Cited Publications
Cat. No.: HY-P1260A
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4
4 Cited Publications
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GB-88 is an oral, selective non-peptide antagonist of PAR2, inhibits PAR2 activated Ca 2+ release with an IC50 of 2 μM .
3
3 Cited Publications
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ENMD-1068 hydrochloride is a selective protease-activated receptor 2 (PAR2) antagonist. ENMD-1068 hydrochloride reduces hepatic stellate cell activation and collagen expression by inhibiting TGF-β1/Smad signaling. ENMD-1068 hydrochloride also inhibits the proliferation of endometrial cells and induces apoptosis of epithelial cells in the lesion. ENMD-1068 hydrochloride can be used in the study of endometriosis and liver fibrosis [2].
3
3 Cited Publications
Cat. No.: HY-P0283
CAS No.: 190383-13-2
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3
3 Cited Publications
Cat. No.: HY-P1314
CAS No.: 729589-58-6
Research Areas:
2
2 Cited Publications
Cat. No.: HY-P1308
CAS No.: 171436-38-7
Synonyms: Protease-Activated Receptor-2 Activating Peptide
Research Areas:
2
Research Areas:
2
2 Cited Publications
Target:
Research Areas:
PAR-2-IN intermediate-1 is a drug intermediate that can be used to synthesize inhibitors of the PAR-2 signaling pathway .
2
2 Cited Publications
Cat. No.: HY-P4803
CAS No.: 202933-49-1
Research Areas:
2
Research Areas:
1
1 Cited Publications
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I-191 is a potent, selective protease-activated receptor 2 (PAR2) antagonist .
1
1 Cited Publications
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AC-55541 is a highly selective protease-activated receptor 2 (PAR2) agonist (pEC50=6.7), displays no activity at other PAR subtypes or at over 30 other receptors involved in nociception and inflammation. AC-55541 has pEC50 values of 5.9 and 6.6 in PI hydrolysis assays and Ca 2+ mobilization assays and exhibits pronociceptive activity in vivo .
1
1 Cited Publications
Cat. No.: HY-120528A
Purity: 99.86%
Research Areas:
GB-110 hydrochloride is a potent, orally active, and nonpeptidic protease activated receptor 2 (PAR2) agonist. GB-110 hydrochloride selectively induces PAR2-mediated intracellular Ca 2+ release in HT29 cells with an EC50 of 0.28 μM .
1
1 Cited Publications
Cat. No.: HY-P1310
CAS No.: 942413-05-0
Research Areas:
Cat. No.: HY-129047A
CAS No.: 9002-07-7
Research Areas:
Trypsin MS grade is a serine protease enzyme, and hydrolyzes proteins at the carboxyl side of the Lysine or Arginine. Trypsin MS grade activates PAR2 and PAR4. Trypsin MS grade induces cell-to-cell membrane fusion in PDCoV infection by the interaction of S glycoprotein of PDCoV and pAPN. Trypsin MS grade also promotes cell proliferation and differentiation. Trypsin MS grade can be used in the research of wound healing and neurogenic inflammation [2] .
Research Areas:
AZ8838 is a potent, competitive, allosteric, orally active non-peptide small molecule antagonist of PAR2 with a pKi of 6.4 for hPAR2 .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
