2. Search Result
Search Result
Results for "

PDK2

" in MedChemExpress (MCE) Product Catalog:

7

Inhibitors & Agonists

1

Antibodies

3

Oligonucleotides

Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-12492
    VER-246608
    4 Publications Verification

    		 PDHK Cancer
    VER-246608 is a potent and ATP-competitive inhibitor of pyruvate dehydrogenase kinase (PDK) with IC50s of 35 nM, 40 nM, 84 nM, and 91 nM for PDK-1, PDK-3, PDK-2, and PDK-4, respectively.
    VER-246608
  • HY-121744
    PS10
    Maximum Cited Publications
    6 Publications Verification

    		 PDHK Inflammation/Immunology
    PS10 is a novel, potent and ATP-competitive pan-PDK inhibitor, inhibits all PDK isoforms with IC50 of 0.8 μM, 0.76 μM, 2.1 μM and 21.3 μM for PDK2, PDK4, PDK1, and PDK3, respectively. PS10 shows high affinity for PDK2 (Kd= 239 nM) than for Hsp90 (Kd= 47 μM) . PS10 improves glucose tolerance, stimulates myocardial carbohydrate oxidation in diet-induced obesity. PS10 has the potential for the investigation of diabetic cardiomyopathy [2].PDK: pyruvate dehydrogenase kinase
    PS10
  • HY-19564
    JX06
    Maximum Cited Publications
    6 Publications Verification

    		 PDHK Apoptosis Cancer
    JX06 is a potent, selective and covalent inhibitor of PDK. JX06 inhibits PDK1, PDK2 and PDK3 with IC50s of 49 nM, 101 nM, and 313 nM, respectively. JX06 inhibits PDK1 activity via covalently binding to a cysteine residue in an irreversible manner. JX06 shows significant antitumor activity .
    JX06
  • HY-18676B
    ILK-IN-2

    OSU-T315 analog

    		 Integrin Autophagy Apoptosis Caspase PDHK Cancer
    ILK-IN-2 (OSU-T315 analog) is an oral PDK2 inhibitor and also an ILK inhibitor, with an IC50 of 0.6 μM. ILK-IN-2 induces cell autophagy and apoptosis, showing anti-tumor activity. ILK-IN-2 directly abolishes AKT activation by preventing AKT from translocating to lipid rafts, triggering Caspase-dependent apoptosis in chronic lymphocytic leukemia (CLL) and extending the lifespan in TCL1 mouse models [2].
    ILK-IN-2
  • HY-RS10276
    PDK2 Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    PDK2 Human Pre-designed siRNA Set A contains three designed siRNAs for PDK2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    PDK2 Human Pre-designed siRNA Set A
    PDK2 Human Pre-designed siRNA Set A
  • HY-RS23367
    Pdk2 Rat Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Pdk2 Rat Pre-designed siRNA Set A contains three designed siRNAs for Pdk2 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Pdk2 Rat Pre-designed siRNA Set A
    Pdk2 Rat Pre-designed siRNA Set A
  • HY-RS16924
    Pdk2 Mouse Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Pdk2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Pdk2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Pdk2 Mouse Pre-designed siRNA Set A
    Pdk2 Mouse Pre-designed siRNA Set A

Inquiry Online

Your information is safe with us. * Required Fields.

Salutation

  

Country or Region *

Applicant Name *

 

Organization Name *

Department *

     

Email Address *

 

Product Name *

Cat. No.

  

Requested quantity *

Phone Number *

     

Remarks

Inquiry Online

Inquiry Information

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent: