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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
15 Results for "
PTPN11
" in MedChemExpress (MCE) Product Catalog:
Products (15)
15 Results for "PTPN11" in MCE Product Catalog:
1
1 Cited Publications
Target:
研究分野:
SPI-112 is a potent, selective and competitive SHP2 (PTPN11) inhibitor with IC50s of 1 μM, 18.3 μM and 14.5 μM for SHP2, protein tyrosine phosphatase (PTP) and PTP1B, respectively .
別名: SHP2-IN-6
Target:
研究分野:
JAB-3068 (SHP2-IN-6) is a potent SHP2 inhibitor, extracted from patent WO2017211303A1, compound 7, has an IC50 of 25.8 nM .
別名: SHP2-IN-6 hydrochloride
Target:
研究分野:
JAB-3068 (SHP2-IN-6) hydrochloride is a potent SHP2 inhibitor with an IC50 of 25.8 nM. JAB-3068 hydrochloride is extracted from patent WO2017211303A1, compound 7 .
製品番号: HY-RS11416
Target:
研究分野:
PTPN11 Human Pre-designed siRNA Set A contains three designed siRNAs for PTPN11 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
製品番号: HY-RS16733
Target:
研究分野:
Ptpn11 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Ptpn11 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
製品番号: HY-RS23169
Target:
研究分野:
Ptpn11 Rat Pre-designed siRNA Set A contains three designed siRNAs for Ptpn11 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
製品番号: HY-114460
CAS 番号: 1801764-90-8
Target:
研究分野:
SHP2-IN-1 (compound 13) is an allergic inhibitor of SHP2 (PTPN11), with an IC50 of 3 nM.
製品番号: HY-120159
CAS 番号: 1710337-31-7
Target:
研究分野:
GS-493 is a selective protein tyrosine phosphatase SHP2 (PTPN11) inhibitor with an IC50 of 71 nM. GS-493 is 29- and 45-fold more active toward SHP2 than related SHP1 and PTP1B. GS-493 blocks cellular motility and growth of cancer cells. Antitumor activity .
製品番号: HY-125259
CAS 番号: 2222280-83-1
Target:
研究分野:
SHP504 is a SHP2 phosphatase inhibitor, with an IC50 of 21 μM for SHP2 1–525 .
製品番号: HY-125257
CAS 番号: 2296718-09-5
別名: LY6
SHP2 inhibitor LY6 (LY6) is a selective SHP2 inhibitor with an IC50 of 9.8 μM, showing 7-fold selectivity over SHP1. SHP2 inhibitor LY6 inhibits SHP2-mediated cell signaling pathways and suppresses cell proliferation. SHP2 inhibitor LY6 elicits induces apoptosis and G2/M cell cycle arrest in lung cancer cells. SHP2 inhibitor LY6 can be used for the research of B cell acute lymphoblastic leukemia, acute myeloid leukemia, and lung cancer .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
