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Results for "

PTPN6

" in MedChemExpress (MCE) Product Catalog:

7

Inhibitors & Agonists

2

Natural
Products

2

Recombinant Proteins

3

Antibodies

3

Oligonucleotides

Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-136657
    SC-43
    5+ Cited Publications

    		 SHP1 Phosphatase STAT Apoptosis Cancer
    SC-43, a Sorafenib derivative, is a potent and orally active SHP-1 (PTPN6) agonist. SC-43 inhibits the phosphorylation of STAT3 and induces cell apoptosis. SC-43 has anti-fibrotic and anticancer effects .
    SC-43
  • HY-119024
    BCI-137

    		SHP1 STAT Cancer
    BCI-137 is a Argonaute 2 (AGO2) inhibitor. By inhibiting AGO2 function, reducing PTPN6/SHP-1 protein levels and enhancing STAT1 phosphorylation, BCI-137 restores the sensitivity of tumor cells to IFN-γ. BCI-137 effectively enhances the recruitment, activation and cytotoxicity of CD8 + T cells. BCI-137 exerts a synergistic effect with anti-PD-1 antibodies and significantly reduces tumor volume in preclinical mouse models. BCI-137 exhibits favorable safety profiles and does not cause significant weight loss or death in mice. BCI-137 can be used in research related to bladder cancer, colorectal cancer, melanoma and other related fields .
    BCI-137
  • HY-N4150
    Quercetagitrin
    1 Publications Verification

    Quercetagetin-7-O-glucoside

    		 Phosphatase Tau Protein NF-κB Neurological Disease Metabolic Disease Inflammation/Immunology
    Quercetagitrin (Quercetagetin-7-O-glucoside) is a natural product that can be isolated from the African marigold (Tagetes erecta). Quercetagitrin has anti-inflammatory activity. Quercetagitrin inhibits Tau accumulation. Quercetagitrin can reverse neuroinflammation and cognitive deficits in P301S-Tau transgenic mouse model through inhibiting NF-κB activation. Quercetagitrin is a dual-target inhibitor of PTPN6 (IC50 = 1 μM) and PTPN9 (IC50 = 1.7 μM). Quercetagitrin enhances glucose uptake by mature C2C12 myoblasts. Quercetagitrin can be studied in research for Alzheimer’s disease and type 2 diabetes .
    Quercetagitrin
  • HY-RS11429
    PTPN6 Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    PTPN6 Human Pre-designed siRNA Set A contains three designed siRNAs for PTPN6 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    PTPN6 Human Pre-designed siRNA Set A
    PTPN6 Human Pre-designed siRNA Set A
  • HY-RS23761
    Ptpn6 Rat Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Ptpn6 Rat Pre-designed siRNA Set A contains three designed siRNAs for Ptpn6 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Ptpn6 Rat Pre-designed siRNA Set A
    Ptpn6 Rat Pre-designed siRNA Set A
  • HY-RS17306
    Ptpn6 Mouse Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Ptpn6 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Ptpn6 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Ptpn6 Mouse Pre-designed siRNA Set A
    Ptpn6 Mouse Pre-designed siRNA Set A
  • HY-N4150R
    Quercetagitrin (Standard)

    Quercetagetin-7-O-glucoside (Standard)

    		 Reference Standards Phosphatase Tau Protein NF-κB Metabolic Disease Inflammation/Immunology Cancer
    Quercetagitrin (Standard) is the analytical standard of Quercetagitrin. This product is intended for research and analytical applications. Quercetagitrin (Quercetagetin-7-O-glucoside) is a natural product that can be isolated from the African marigold (Tagetes erecta). Quercetagitrin has anti-inflammatory activity. Quercetagitrin inhibits Tau accumulation. Quercetagitrin can reverse neuroinflammation and cognitive deficits in P301S-Tau transgenic mouse model through inhibiting NF-κB activation. Quercetagitrin is a dual-target inhibitor of PTPN6 (IC50 = 1 μM) and PTPN9 (IC50 = 1.7 μM). Quercetagitrin enhances glucose uptake by mature C2C12 myoblasts. Quercetagitrin can be studied in research for Alzheimer’s disease and type 2 diabetes .
    Quercetagitrin (Standard)

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