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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
12 Results for "
PTPN6
" in MedChemExpress (MCE) Product Catalog:
Products (12)
12 Results for "PTPN6" in MCE Product Catalog:
6
6 Publications Verification
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SC-43, a Sorafenib derivative, is a potent and orally active SHP-1 (PTPN6) agonist. SC-43 inhibits the phosphorylation of STAT3 and induces cell apoptosis. SC-43 has anti-fibrotic and anticancer effects .
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1 Cited Publications
BCI-137 is a Argonaute 2 (AGO2) inhibitor. By inhibiting AGO2 function, reducing PTPN6/SHP-1 protein levels and enhancing STAT1 phosphorylation, BCI-137 restores the sensitivity of tumor cells to IFN-γ. BCI-137 effectively enhances the recruitment, activation and cytotoxicity of CD8 + T cells. BCI-137 exerts a synergistic effect with anti-PD-1 antibodies and significantly reduces tumor volume in preclinical mouse models. BCI-137 exhibits favorable safety profiles and does not cause significant weight loss or death in mice. BCI-137 can be used in research related to bladder cancer, colorectal cancer, melanoma and other related fields .
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Flavonols Flavonoids Erythrina melanacantha Taub. ex Harms Phenols Polyphenols Plants Compositae Disease Research Fields Inflammation/Immunology
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1 Cited Publications
Cat. No.: HY-P71141
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: Tyrosine-Protein Phosphatase Non-Receptor Type 6; Hematopoietic Cell Protein-Tyrosine Phosphatase; Protein-Tyrosine Phosphatase 1C; PTP-1C; Protein-Tyrosine Phosphatase SHP-1; SH-PTP1; PTPN6; HCP; PTP1C
Cat. No.: HY-RS11429
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PTPN6 Human Pre-designed siRNA Set A contains three designed siRNAs for PTPN6 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS17306
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Ptpn6 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Ptpn6 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS23761
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Ptpn6 Rat Pre-designed siRNA Set A contains three designed siRNAs for Ptpn6 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-P73649
Purity: ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: Tyrosine-protein phosphatase non-receptor type 6; 70Z-SHP; PTP-1C; SHP-1; PTPN6
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Cat. No.: HY-P81307AA
Synonyms: PTPN6; HCP; PTP1C; Tyrosine-protein phosphatase non-receptor type 6; Hematopoietic cell protein-tyrosine phosphatase; Protein-tyrosine phosphatase 1C; PTP-1C; Protein-tyrosine phosphatase SHP-1; SH-PTP1
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
